Oncology Probes

ON PTEN (10q23) / SE 10The gene ‘phosphatase and tensin homolog deleted onchromosome 10’ (PTEN), is a tumor suppressor locatedat chromosome 10q23, that plays an essential role in themaintenance of chromosomal stability, cell survival andproliferation. Loss of PTEN has been found in a wide numberof tumors, and his important role is demonstrated by the factthat it is the second most frequently mutated gene after p53.Loss of PTEN significantly correlates with the advanced formsof gliomas, but also of prostate cancer and breast tumors.The PTEN (10q23) specific DNA probe is optimized to detectcopy numbers of the PTEN gene region at region 10q23.The Chromosome 10 Satellite enumeration probe (SE 10) atD10Z1 is included to facilitate chromosome identification.ON C-MET (7q31) / SE 7The C-MET proto-oncogene is a receptor-like tyrosine kinasethat drives a physiological cellular program important fordevelopment, cell movement, cell repair, cellular growth.Aberrant execution of the program has been associated toneoplastic transformation, invasion and metastasis. Activationof C-MET has been reported in a significant percentage ofhuman cancers and is amplified during the transition betweenprimary tumors and metastasis.The C-MET (7q31) specific DNA probe is optimized to detectcopy numbers of the C-MET gene region at region 7q31. TheChromosome 7 Satellite enumeration probe (SE 7) at D7Z1 isincluded to facilitate chromosome identification.Cat.# KBI-10718 PTEN (10q23) / SE 10Cat.# KBI-10719 C-MET (7q31) / SE 7D10Z1RH113215PTEN480 KBD7Z1D7S3086WI-2224910q23C-MET420 KBSHGC-1431537q31RH110508107Oncology Probes - Solid TumorsPTEN (10q23) / SE 10 probe hybridized to prostate cancer materialshowing deletion of PTEN gene region at 10q23 (1R2G).Image kindly provided by Portuguese Cancer Inst., PortoLiterature:Cairns et al, 1997, Cancer Res, 57 ; 4997-5000Hermans et al, 2004, Genes Chrom Cancer, 39; 171-184Ordering information Color Tests Cat#ON PTEN (10q23) / SE 10 red/green 10 KBI-10718C-MET (7q31) / SE 7 probe hybridized to colon tissue (2R2G).Literature:Hara et al, 1998, Lab Invest 78; 1143-1153.Tsugawa et al., 1998, Oncology 55; 475-481.Ordering information Color Tests Cat#ON C-MET (7q31) / SE 7 red/green 10 KBI-1071960