Oncology Probes

Different Cancer typesON EGFR, Her-1 (7p11) / SE 7Epidermal growth factor receptor (EGFR) is a cell membraneprotein, providing signal transduction and cell growth. It is amember of the Her or Erb-B family of type I receptor tyrosinekinases and implicated in the development and progressionof cancer of the lung, breast, intestine, and other organs.EGFR was found to act as a strong prognostic indicator inhead and neck, ovarian, cervical, bladder and oesophagealcancers. In these cancers, increased EGFR expression wasassociated with reduced recurrence-free or overall survival.The EGFR (7p11) specific DNA probe is optimized to detectcopy numbers of the EGFR (Her1) gene region at region 7p11.The chromosome 7 satellite enumeration probe (SE 7) at D7Z1is included to facilitate chromosome identification.ON hTERT (5p15) / 5q31 (tissue)Amplification of the hTERT gene at band 5p15 has beenobserved in a variety of cancer, particularly lung cancer,cervical tumors, and breast carcinomas. Several studies haverevealed a high frequency of hTERT gene amplification inhuman tumors, which indicates that the hTERT gene maybe a target for amplification during the transformation ofhuman malignancies and that this genetic event probablycontributes to a dysregulation of hTERT/telomerase occurringin a subset of human tumors.The hTERT (5p15) probe is designed as a dual-color assay todetect amplification at 5p15. The CDC25C/EGR1 (5q31) generegion probe is included as internal control.Cat.# KBI-10702 EGFR, Her1 (7p11) / SE 7Cat.# KBI-10709 hTERT (5p15) / 5q31 (tissue)5p15.3D7Z1RH1058587p11.2HER1-EGFR340 KBD5S1981hTERTD5S2269190 KBD7S2357RH480325q31.2CDC25C7645 KB5EGR1D5S597EGFR, Her1 (7p11) / SE 7 hybridized to colon tissue (2R2G).Literature:Wang et al, 1993, Jpn J Hum Genet, 38: 399-406.Nicholoson et al, 2001, Eur J Cancer, 37: 9-15.Ordering information Color Tests Cat#ON EGFR, Her-1 (7p11) / SE 7 red/green 10 KBI-10702hTERT (5p15) / 5q31 (tissue) probe hybridized to paraffineembedded tissue (2R2G).Literature:Bryce et al, 2000, Neoplasia, 2; 197-201.Zhang et al, 2000, Cancer Res, 60; 6230-6235.Ordering information Color Tests Cat#ON hTERT (5p15) / 5q31 (tissue) red/green 10 KBI-10709Oncology Probes - Solid Tumors59