Oncology Probes

ON SYT (18q11) BreakThe characteristic chromosomal abnormality in synovialsarcoma is t(X;18)(p11.2;q11.2) present in 90% of patients.This translocation results in the fusion of the chromosome18 SYT gene to either of two distinct genes, SSX1 or SSX2,located on the X chromosome.A break or split probe for SYT is best used to analyzetranslocation of the SYT (SS18) gene on formalin fixed paraffinembedded tissue for routine clinical diagnosis.ON CHOP (12q13) BreakLiposarcoma is one of the most frequent sarcomas in adults,representing 10 to 16 percent of soft tissue sarcomas.Most patients with round cell/myxoid liposarcoma havean acquired t(12;16)(CHOP-FUS) or t(12;22)(CHOP-EWS)translocation, both of which involve the CHOP gene at12q13. A break or split probe for CHOP is best used to analyzetranslocation of the CHOP (12q13) gene on formalin fixedparaffin embedded tissue for routine clinical diagnosis.The CHOP (12q13) Break probe is optimized to detecttranslocations involving the CHOP gene region at 12q13 ina dual-color, split assay.Cat.# KBI-10713 SYT (18q11) BreakCat.# KBI-10714 CHOP (12q13) BreakRH 22533RH 7535318q111077 KB12q13700 KBSYT (SS18)CHOP18RH 118756717 KB12RH 118682680 KBOncology Probes - Solid TumorsSYT (18q11) Break probe hybridized to patient materialshowing translocation of the SYT (SS18) gene region at18q11 (1RG1R1G).Literature:Kawai et al, 1998, NEJM, 338; 153-160Surace et al, 2004, LabInvest., 84; 1185-1192Ordering information Color Tests Cat#ON SYT (18q11) Break red/green 10 KBI-10713CHOP (12q13) Break probe hybridized to a normalmetaphase (2RG).Literature:Panagopoulos et a, 1994, Cancer Res, 54; 6500-6503.Schoenmakers et al, 1994, Genomics, 20; 210-222.Ordering information Color Tests Cat#ON CHOP (12q13) Break red/green 10 KBI-1071456