Oncology Probes

NeuroblastomaAccording to the International Neuroblastoma RiskGrouping (INRG) Biology Committee MYCN remainsthe only genomic factor to be used currently fortreatment stratification. Common data elements tobe obtained by all groups include tumor cell ploidyand copy number/LOH status at chromosome bands1p36, 11q23, and 17q23-25.Literature:Ambros et al, 2006, Advances in Neuroblastoma ResearchON MYCN (2p24) / LAF (2q11)Amplification of the human N-myc protooncogene, MYCN, isfrequently seen either in extrachromosomal double minutesor in homogeneously staining regions of aggressivelygrowing neuroblastomas. MYCN amplification has beendefined by the INRG as > 4-fold MYCN signals comparedto 2q reference probe signals.The MYCN (2p24) specific DNA probe is optimized todetect copy numbers of the MYCN gene region at 2p24.The LAF gene region probe at 2q11 is included to facilitatechromosome identification.Cat.# KBI-10706 MYCN (2p24) / LAF (2q11)D2S26762p24.3MYCN450 KBRH1129072q11.2LAF4375 KB2Oncology Probes - Solid TumorsMYCN (2p24) / LAF (2q11) hybridized to a cell line showingamplification of MYCN on chromosome 13 and 15.Image kindly provided by Pasteur Workshop 2008, ParisLiterature:Shapiro et al, 1993, Am J Pathol, 142: 1339-1346.Corvi et al, 1994, PNAS, 91: 5523-5527..Ordering information Color Tests Cat#ON MYCN (2p24) / LAF (2q11) red/green 10 KBI-1070652