Oncology Probes

Bladder CancerON p16 (9p21) / 9q21 (tissue)Homozygous and hemizygous deletions of 9p21 are theearliest and most common genetic alteration in bladdercancer. The p16 (INK4A) gene has been identified as tumorsuppressor gene in this region which is commonly deleted inbladder cancer. The loss of DNA sequences on chromosomalbands 9p21-22 has been documented also in a variety ofmalignancies including leukemias, gliomas, lung cancers, andmelanomas.The p16 (9p21) specific DNA probe is optimized to detectcopy numbers of the p16 gene region at region 9p21. The9q21 region probe is included to facilitate chromosomeidentification.Cervical CancerON CC hTERC (3q26) / C-MYC (8q24) / SE 7 TCCervical cancer, a potentially preventable disease, remainsthe second most common malignancy in women worldwide.The most consistent chromosomal gain in aneuploid tumorsof cervical squamous cell carcinoma mapped to chromosomearm 3q, including the human telomerase gene locus (hTERC)at 3q26. High-level copy number increases were also mappedto chromosome 8. Integration of HPV (Human Papilloma Virus)DNA sequences into C-MYC chromosomal regions have beenrepeatedly observed in cases of invasive genital carcinomasand in cervical cancers. The hTERC (3q26) specific DNA Probe isoptimized to detect copy numbers of the hTERC gene region atregion 3q26. The C-MYC (8q24) specific DNA probe is optimizedto detect copy numbers of the C-MYC gene region at 8q24. Thechromosome 7 satellite enumeration probe (SE 7) at D7Z1 isincluded as ploidy control.Cat.# KBI-10710 p16 (9p21) / 9q21 (tissue)Cat.# KBI-10704 Cervical Cancer hTERC (3q26)/ C-MYC (8q24) / SE 7 Triple-Color9p21D9S1749p16400 KBRH779669q21p15D9S975C-MYC570 KB9RH179193q26.2 hTERC370 KB8RH133888q24.1RH106063Oncology Probes - Solid Tumors50p16 (9p21) / 9q21 (tissue) probe hybridized to tissue (2R2G).Literature:Stadler et al, 1994, Cancer Res, 54: 2060-2063.Williamson et al, 1995, Hum Mol Genet, 4: 1569-1577.Ordering information Color Tests Cat#ON p16 (9p21) / 9q21 (tissue) red/green 10 KBI-10710CC hTERC (3q26) / C-MYC (8q24) / SE 7 TC probe hybridized to aPAP smear (destained) showing 3q26 and 8q24 amplification.The SE 7 control probe indicates a non-triploid karyotype (2B).Image kindly provided by Dr Weimer, KielLiterature:Heselmeyer et al, 1996, PNAS, 93: 479-484.Herrick et al, 2005, Cancer Res, 65: 1174-1179.Ordering information Color Tests Cat#ON CC hTERC (3q26) / C-MYC (8q24) / SE 7 TC red/green 10 KBI-10704