Oncology Probes

ON MM 1q21 / SRD (1p36)Frequent loss of heterozygosity (LOH) on the short arm ofchromosome 1 (1p) has been reported in a series of humanmalignancies. The combination with the potentially amplified1q21 region allows to detect deletions at 1p36 and gain of1q21 in a single FISH assay.The 1q21 specific DNA probe is optimized to detect copynumbers at 1q21. The SRD 1p36 specific DNA Probe isoptimized to detect copy numbers of 1p at region 1p36containing the markers D1S2795 and D1S253.ON IGH (14q32) BreakMultiple myeloma is characterized by complex rearrangementsinvolving the IgH gene, particularly at the constant locus. TheIgH rearrangement provides a useful marker of clonality inB-cell malignancies and amplification of this rearrangementis the method of choice to monitor the residual tumor cellsin multiple myeloma.The IGH (14q32) break probe is optimized to detecttranslocations involving the IGH gene region at 14q32 in adual-color, split assay.Cat.# KBI-10507 MM 1q21 / SRD (1p36)Cat.# KBI-10601 IGH (14q32) Break1p36.3D1S2795SHGC-149299CHD5D1S286E530 KBD1S2531q21D1S1953ES100A10330 KB1SHGC-144740See description under Lymphoma on page 42.MM 1q21 / SRD (1p36) hybridized to a normalmetaphase (2R2G).Literature:Cremer et al, 2005, Genes Chrom Cancer, 44: 194-203.Shaughnessy J., 2005, Hematology, 10 suppl 1: 117-126.Ordering information Color Tests Cat#ON 1q21 / SRD (1p36) red/green 10 KBI-10507Literature:Taniwaki et al, 1994, Blood, 83: 2962-1969.Moreau et al, 2002, Blood, 100: 1579-1583.Ordering information Color Tests Cat#ON IGH (14q32) Break red/green 10 KBI-10601Oncology Probes - Hematology Probes39