Oncology Probes

ON MM 1q21 / 8p21Amplifications of 1q21 are concurrent with dysregulatedexpression of c-MAF, MMSET/FGFR3, or Del13 and representan independent unfavorable prognostic factor. Allelic lossesof the chromosome 8p21-22 have been reported as a frequentevent in several cancers.The 1q21 specific DNA probe is optimized to detect copynumbers at 1q21. The 8p21 specific DNA region is optimizedto detect copy numbers at 8p21.ON MM 19q13 / p53 (17p13)P53 gene deletion, which can be identified by interphaseFISH in almost a third of patients with newly diagnosed MM,is a novel prognostic factor predicting for short survival ofMM patients treated with conventional-dose chemotherapy.Amplification of 19q13 has been reported in a variety ofcancer.The 19q13 specific DNA probe is optimized to detect copynumbers at 19q13. The p53 (17p13) specific DNA region isoptimized to detect copy numbers of the p53 gene region at17p13.Cat.# KBI-10503 MM 1q21 / 8p21Cat.# KBI-10509 MM 19q13 / p53 (17p13)8p21.1WI-1821RH1443317p13D1S1953EPNOCRH81368205 KB19CD3719q13.3RH20642340 KB17D17S960P53D17S634330 KB1q21S100A10330 KB8SHGC-1447401MM 1q21 / 8p21 hybridized to a normal metaphase (2R2G).Literature:Shaughnessy J., 2005, Hematology, 10 suppl 1: 117-126.Cremer et al, 2005, Genes Chrom Cancer, 44: 194-203.Ordering information Color Tests Cat#ON MM 1q21 / 8p21 red/green 10 KBI-10503MM 19q13 / p53 (17p13) hybridized to patient material showinga p53 (17p13) deletion (1R2G).Image kindly provided by Prof Jauch, HeidelbergLiterature:Drach et al, 1998, Blood, 92: 802-809.Cremer et al, 2005, Genes Chrom Cancer, 44: 194-203.Ordering information Color Tests Cat#ON MM 19q13 / p53 (17p13) red/green 10 KBI-10509Oncology Probes - Hematology Probes37