Oncology Probes

ON ETV6 (TEL) (12p13) BreakETV6 (TEL) gene is the abbreviation for -ETS variant 6-gene. It encodes an ETS family factor which functions as atranscriptional repressor in hematopoiesis and in vasculardevelopment. The gene is located on chromosome 12p13, andis frequently rearranged in human leukemias of myeloid orlymphoid origins. Also systematic deletion of the normal ETV6allele in patients with ETV6-AML1 fusions can be found.ON p16 (9p21) / 9q21Hemizygous deletions and rearrangements of chromosome9, band p21, are among the most frequent cytogeneticabnormalities detected in pediatric acute lymphoblasticleukemia (ALL). This deletion includes loss of the p16 (INK4A)/p15 (INK4B) genes, which are cell cycle kinase inhibitors andimportant in leukemogenesis.The p16 (9p21) specific DNA probe is optimized to detectcopy numbers of the p16 (INK4A) gene region at region 9p21.The 9q21 region probe is included to facilitate chromosomeidentification.Cat.# KBI-10403 ETV6 (TEL) (12p13) BreakCat.# KBI-10402 p16 (9p21) / 9q21RH 7797212p13495 KB9p21D9S1749ETV6D12S922545 KB9q21p16p15D9S975400 KB129ETV6 (TEL) (12p13) Break probe hybridized to patientmaterial showing a translocation involving the ETV6 regionat 12p13 (1RG1R1G).Image kindly provided by Magret Ratjen, KielLiterature:Golub et al, 1995, PNAS 92; 4917-4921Ford et al, 2001, Blood 98; 558-564Ordering information Color Tests Cat#ON ETV6 (TEL) (12p13) Break red/green 10 KBI-10403p16 (9p21) / 9q21 hybridized on patient material showingan isochromosome 9.Image kindly provided by Dr Wenzel, BaselLiterature:Dreyling et al, 1995, Blood, 86: 1931-1938.Southgate et al, 1995, Br J Cancer, 72: 1214-1218.Ordering information Color Tests Cat#ON p16 (9p21) / 9q21 red/green 10 KBI-10402Oncology Probes - Hematology Probes33