Oncology Probes

ON MDS 7q- (7q22; 7q35) / SE 7 TCThe 7q- specific DNA probe is optimized to detect copynumber of 7q at 7q22 and at 7q35 simultaneously in a dualcolorassay.The chromosome 7 satellite enumeration probe (SE 7) at D7Z1in blue is included to facilitate chromosome identification.ON MDS 20q- (PTPRT 20q12) / 20q11Acquired deletions of the long arm of chromosome 20 arefound in several hematologic conditions and particularly inthe myeloproliferative disorders (MPD) and myelodysplasticsyndromes and acute myeloid leukemia (MDS/AML). A minimalcritical region deleted in MPD and MDS has been identifiedat 20q12 which includes a protein tyrosine phosphatasereceptor gene (PTPRT).The 20q- (PTPRT, 20q12) specific DNA probe is optimizedto detect copy numbers of 20q at region 20q12. A 20q11region specific probe is included to facilitate chromosomeidentification.Cat.# KBI-10207 MDS 7q (7q22; 7q35) / SE 7, Triple-ColorCat.# KBI-10203 MDS 20q- (PTPRT 20q12) / 20q11D7Z1ControlSHGC-144070MAPRE1600 KB20q11.21CUTL1200 KBRH574677q22D7S74020q1220D20S108360 KB77q35D7S2419D20S499PTPRT320 KBD7S688D7S2640MDS 7q (7q22; 7q35) / SE 7 TC probe hybridized to anormal metaphase (2R2G2B).Literature:LeBeau et al., 1996, Blood, 88: 1930-1935.Doehner et al, 1998, Blood, 92: 4031-4035.Ordering information Color Tests Cat#ON MDS 7q- (7q22; 7q35) / SE7 TC red/green/blue 10 KBI-10207MDS 20q- (PTPRT 20q12) / 20q11 probe hybridized to anormal metaphase (2R2G).Literature:Bench et al, 2000, Oncogene, 19: 3902-3913.Asimakopoulos et al, 1994, Blood, 84: 3086-3094.Ordering information Color Tests Cat#ON 20q- (PTPRT 20q12) / 20q11 red/green 10 KBI-10203Oncology Probes - Hematology Probes27