Oncology Probes

ON hTERC (3q26) / 3q11Amplification of the 3q26-q27 has a high prevalence incervical, prostate, lung, and squamous cell carcinoma.This amplification can also be found to a lesser extentin CLL patients. The minimal region of amplification wasrefined within a 1- to 2-Mb genomic segment containingseveral potential cancer genes including hTERC, the humantelomerase RNA gene.The hTERC (3q26) specific DNA probe is optimized to detectcopy numbers of the hTERC gene region at region 3q26.The 3q11 region probe is included to facilitate chromosomeidentification.ON GLI (12q13) / SE 12Trisomy 12 is the most common numerical chromosomalaberration in patients with B-cell chronic lymphocytic leukemia(B-CLL). Partial trisomy 12 of the long arm of chromosome 12consistently includes a smaller region at 12q13-15 and hasbeen observed in CLL and several other tumors. A number ofloci located close to either MDM2 or CDK4/SAS, including thegenes GADD153, GLI, RAP1B, A2MR, and IFNG, were foundto be coamplified.The GLI (12q13) specific DNA probe is optimized to detectcopy numbers of the GLI gene region at region 12q13. Thechromosome 12 satellite enumeration probe (SE 12) D12Z3is included to facilitate chromosome identification.Cat.# KBI-10110 hTERC (3q26) / 3q11Cat.# KBI-10104 GLI (12q13) / SE 12D12Z3RH 10132012q13GLI270 KB3q11RH 75890RH179193q26.2 hTERCRH10606370 KB123hTERC (3q26) / 3q11 probe hybridized to a normal interphase/metaphase (2R2G).Literature:Arnold et al, 1996, Genes Chrom Cancer, 16: 46-54.Soder et al, 1997, Oncogene, 14: 1013-1021.Ordering information Color Tests Cat#ON hTERC (3q26) / 3q11 red/green 10 KBI-10110GLI (12q13) / SE 12 hybridized to patient material showingGLI (12q13) amplification (3R2G).Image kindly provided by Dr Wenzel, BaselLiterature:Merup et al, 1997, Eur J Haematol, 58: 174-180.Dierlamm et al., 1997, Genes Chrom Cancer, 20: 155-166.Ordering information Color Tests Cat#ON GLI (12q13) / SE 12 red/green 10 KBI-10104Oncology Probes - Hematology Probes21