Oncology Probes

CML secondary chromosomal changesON p53 (17p13) / MPO (17q22) “ISO 17q”Isochromosome 17q is the most common isochromosomein cancer. It plays an important role in tumor developmentand progression. Hematologic malignancies such as chronicmyeloid leukemia (CML) with isochromosome 17q carry apoor prognosis. Isochromosome 17q is the most commonchromosome abnormality in primitive neuroectodermaltumors and medulloblastoma. Isochromosome 17q is, byconvention, symbolized as i(17q).The p53 (17p13) / MPO (17q22) “ISO 17q” probe is optimizedto detect copy numbers of the p53 gene region at 17p13 andMPO gene region at 17q22. In case of i(17q) a signal patternof three red signals for MPO (17q22) and one signal for p53at 17p13 is expected.SE 8 (D8Z1)SE 7 (D7Z1) / SE 8 (D8Z1)Gain of chromosome 8 is the most common secondarychromosomal aberration in CML (approx. 34%).Cat.# KBI-10011 p53 (17p13) / MPO (17q22) “ISO 17q”Cat.# KBI-20008 SE 8 (D8Z1)Cat.# KBI-20031 SE 7 (D7Z1) / SE 8 (D8Z1)D17S96017p13P53D17S634330 KB17q22D17S215117 MPO 400 KBSHGC-144222See description under Satellite Enumeration probeson page 84.p53 (17p13) / MPO (17q22) "ISO 17q" hybridized to a normalmetaphase (2R2G).Literature:Becher et al, 1990, Blood, 75: 1679-1683.Fioretos et al, 1999, Blood, 94: 225-232.Ordering information Color Tests Cat#ON p53 (17p13) / MPO (17q22) “ISO 17q” green/red 10 KBI-10011Ordering information Color Tests Cat#SE 8 (D8Z1) red/green 10 KBI-20008SE 7 (D7Z1) / SE 8 (D8Z1) red/green 10 KBI-20031Oncology Probes - Hematology Probes15