Oncology Probes

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Product Selection GuideULSArray CGHULS array CGH Labeling Kit104cDNAULS cDNA Synthesis and Labeling Kit104Gene ExpressionLabelingULS aRNA Labeling Kits106aRNAAmplification& LabelingRNA ampULSe Kits106MicroarrayLabelingmiRNA detectionULS microRNA Labeling Kit107Protein arraysULS Protein Labeling Kits108General NucleicAcid LabelingPlatinumBright Kits109Product Selection GuideAntibodyLabelingPlatinumLink Kits110102
THE ULS LABELING TECHNOLOGYIntroductionONE LABELING Technology for all Microarray and FISH applicationsThe proprietary ULS (Universal Linkage System) technology provides the basis for KREATECH’s broad rangeof labeling applications. ULS labeling is based on the stable coordinative binding properties of platinum tonucleic acids and proteins. The ULS molecule consists of a platinum complex, a detectable molecule and aleaving group which is displaced upon reaction with the target. This reaction results in a coordinative bond,firmly coupling the ULS to the target. ULS labels DNA and RNA by binding to the N7 position of guanine. Inproteins, ULS binds to sulfur and nitrogen containing side chains of methionine, cysteine and histidine. ULS isavailable coupled to a variety of labels and haptens, including fluorochromes and biotin. The labeling reactionallows a wide range of conditions and produces a highly stable bond.Principle of the ULS technologyTargets labeled with ULSNucleic AcidsGuanineULS labels DNA andRNA by forming acoordinative bondon the N7 positionof guanineProteinsMethionine, Cysteine, HistidineULS labels proteins by forminga coordinative bond on thesulfur atoms of methionine,cysteine and the nitrogen atomof histidineUnique features of the ULS Labeling Technology• Time saving: Entire labeling procedure in only 30 minutesfor DNA and 15 minutes for RNA• Easy to use• Robust and reproducible – no enzymes involved• Superior labeling technology for FFPE samples• One technology for all applications• Compatible with all microarray platformsThe ULS Labeling Technology103
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KREATECH DiagnosticsProduct Guide
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Product Selection GuideI want to us
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HUGO Gene SymbolsThe table below gi
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Oncology probes - Hematology Probes
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Chronic Myeloproliferative Disorder
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ON BCR/ABL t(9;22), DC, S-Fusion, E
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Other Myeloproliferative Diseases:O
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Chronic Lymphocytic Leukemia (CLL)C
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ON hTERC (3q26) / 3q11Amplification
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ON hTERT (5p15) / 5q31The hTERT / 5
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ON MDS 7q- (7q22; 7q35) / SE 7 TCTh
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Acute Myeloid Leukemia (AML)At leas
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ON RARA (17q21) BreakThis break apa
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ON ETV6 (TEL) (12p13) BreakETV6 (TE
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ON MM 1q21 / 8p21Amplifications of
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ON MM 1q21 / SRD (1p36)Frequent los
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ON IGH (14q32) BreakChromosomal rea
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ON BCL6 (3q27) BreakChromosomal tra
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Oncology probes - Solid TumorsIn so
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ON TOP2A (17q21) / Her2 (17q12) / S
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Bladder CancerON p16 (9p21) / 9q21
Page 52 and 53: NeuroblastomaAccording to the Inter
Page 54 and 55: ON p53 (17p13) / MPO (17q22) “ISO
Page 56 and 57: ON SYT (18q11) BreakThe characteris
Page 58 and 59: ON MDM2 (12q15) / SE 12Fibrosarcoma
Page 60 and 61: ON PTEN (10q23) / SE 10The gene ‘
Page 62 and 63: ON CCND1 (11q13) / SE 11CCND1 (also
Page 64 and 65: ON BCL6 (3q27) Break (tissue)Chromo
Page 66 and 67: Preimplantation Genetic ScreeningFI
Page 68 and 69: Prenatal probesPrenatal cytogenetic
Page 70 and 71: Microdeletion probesMicrodeletion s
Page 72 and 73: MD DiGeorge “TUPLE” (22q11) / 2
Page 74 and 75: MD NSD1 (5q35) / hTERT (5p15)NSD1 m
Page 76 and 77: MD Angelman UBE3A (15q11) / PML (15
Page 78 and 79: MD Wolf-Hirschhorn WHSC1 (4p16)Wolf
Page 80 and 81: MD STS (Xp22) / KAL (Xp22) / SE X T
Page 82 and 83: Sub-Telomere probesTelomeres are sp
Page 84 and 85: Satellite Enumeration probesThe pri
Page 86 and 87: Whole Chromosome probesThe Poseidon
Page 88 and 89: Arm Specific ProbesArm Specific Pro
Page 90 and 91: Mouse FISH ProbesNew applications f
Page 92 and 93: Chromogenic In Situ HybridizationCh
Page 94 and 95: cell culture mediaKREAvital cytogen
Page 96 and 97: PhytohaemagglutininPhytohaemaggluti
Page 98 and 99: Kits and ReagentsThe ready-to-use p
Page 100 and 101: FISHBright labeling kitsThe FISHBr
Page 104 and 105: DNA LABELINGULS arrayCGH Labeling K
Page 106 and 107: RNA LABELINGAMPLIFICATION AND aRNA
Page 108 and 109: PROTEIN LABELINGPROTEIN LABELING AN
Page 110 and 111: Antibody LABELINGPlatinumLink Antib
Page 112 and 113: Technical AppendixThe Poseidon Prob
Page 114 and 115: TERMS AND CONDITIONSTerms and Condi
Page 116 and 117: Product IndexOncology probes - Hema
Page 118 and 119: Satellite Enumeration probesSE = Sa
Page 120 and 121: Arm-Specific Probesready-to-useDesc
Page 122 and 123: Mouse FISHDescription Color Tests C
Page 124 and 125: DNA LabelingDescription Reactions C
Page 126 and 127: How To OrderHow to place an orderOr
Page 128: © 2010 KREATECH DiagnosticsPublish
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Oncology Probes

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