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The 11 th International Workshop on KSHV & Related Agents, Birmingham, UK Session 5 abstracts 29-34: Gene Expression I 52
The 11 th International Workshop on KSHV & Related Agents, Birmingham, UK Gene Expression I Abstract 29 SCREENING FOR XINJIANG KS ASSOCIATED GENES AND THE STUDY ON THEIR MECHANISMS Lei YANG, Yan ZENG, Dong-Mei LI,Ling-ling XIAN,Xiao –Fei ZHOU,Xiao-Hua TAN,Jin HUANG,Feng LI,Jian-Xin XIE,Hui ZHANG,Sheng Wang,Xian-Dao LUO Key Laboratory of Xinjiang Endemic and Ethnic Disease, Shihezi University,Shihezi, XinJiang, 832002, China Abstract In China, classical KS mainly occurs in Uygur and Kazak ethic group in Xinjiang Autonomous Region. The occurrence and development of sarcoma is linked with the abnormality of genes. For comprehensive clarifying the pathogenesis of KS in Xinjiang, We screened the differentially expressed genes between KS’ tissues and normal skin tissues from an classical patient of Uygur by Suppression subtractive hybridization (SSH). We cloned and sequenced them and established differential expression cDNA library on the base of SSH.Then we enlarged the samples and selected 4 classic patients to do the further screening by human genome U133 plus 2.0 microarray (Affymetrix). According to the bioinformatics analysis,we got the congenerous differentially expressed genes nearly 80. The function of them are focused on signal transduction and correlated with apoptosis or tumor occurrence. These studies identified a large number of genes whose expression was altered in KS. we have verified some of these differentially expressed genes by Real-time PCR and Immunohistochemistry, it’s consistent with the SSH and gene chip results.We have carried on some functional study on these genes,such as 14- 3-3β, HO-1, Neuritin, EGFR, MMP14, LYN, et al. We detected the expression level of KS associated genes in BC-3 cells and Human umbilical vein endothelial cells to analyze if infection of HHV8 have effect on the expression of these genes .Most of these genes were related with the infection of HHV8 and participate in cell proliferation, apoptosis and this might show particular relation in the pathogenesis of KS. Presenting author Email: zengyan910@yahoo.com.cn 53
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