Contents - College of Medical and Dental Sciences - University of ...
Contents - College of Medical and Dental Sciences - University of ...
Contents - College of Medical and Dental Sciences - University of ...
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The 11 th International Workshop on KSHV & Related Agents, Birmingham, UK<br />
Poster Session Abstract P7<br />
SUMO-MODIFICATION MODULATES THE SUBCELLULAR LOCALIZATION AND<br />
ACTIVITY OF THE KSHV LATENT PROTEIN LANA2<br />
1 2 3 3 2<br />
Laura Marcos-Villar, Pedro Gallego, Fern<strong>and</strong>o Lopitz, Manuel S Rodriguez & Carmen<br />
Rivas<br />
1Dpt Microbiologia II, Fac Farmacia, Universidad Complutense de Madrid, Madrid, Spain;<br />
2 Dpt Biología Molecular y Celular, Centro Nacional de Biotecnología, CSIC, Madrid, Spain;<br />
3 Ubiquitin-like proteins & Cancer Group, Proteomics Unit. CIC-BioGUNE, Derio, Spain.<br />
Abstract<br />
Small ubiquitin-related modifier (SUMO) family proteins function by becoming covalently<br />
attached to other proteins as post-translational modifications. SUMO modifies many<br />
proteins that participate in diverse processes, including transcriptional regulation, nuclear<br />
transport, maintenance <strong>of</strong> genome integrity, <strong>and</strong> signal transduction. The functional<br />
consequences <strong>of</strong> SUMO attachment vary greatly from substrate to substrate; however,<br />
two general modes <strong>of</strong> action have been suggested. Sumoylation may alter protein<br />
stability or may alter protein-protein interactions that could result in a variety <strong>of</strong><br />
consequences, including changes in cellular localization.<br />
LANA2 is a multifunctional protein exclusively expressed in KSHV infected B cells that is<br />
required for the survival <strong>of</strong> KSHV-infected primary effusion lymphoma cells. Studies<br />
carried out in our laboratory demonstrate that LANA2 is covalently modified by SUMO.<br />
Sumoylation <strong>of</strong> LANA2 does not affect protein stability but modulates its subcellular<br />
localization <strong>and</strong> protein activity.<br />
Presenting author Email: lmarcos@cnb.csic.es<br />
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