In the name of ALLAH The All Compassionate The All ...
In the name of ALLAH The All Compassionate The All ... In the name of ALLAH The All Compassionate The All ...
ABSTRACTSThe 1 st International Congress on Gynecological Oncology52False Positive or Phantom hCG Result:A Serious Problem in GTN Follow-UpDr. Tahereh AshrafganjooeiAssociate Professor, fellow of Gynecologic Oncology Department of Gynecology,Shahid Beheshti Medical UniversityGynecology oncology Department, Emam Hosein hospital, Shahid Madani Street,Tehran, IranPhone number: 0098-21-77558081dr _ ganjooei@hotmail.comBackground: Gestational trophoblastic neoplasia (GTN) refers to a subset of GTDwith a persistently elevated serum hCG in the absence of a normal pregnancy andwith a history of normal or abnormal pregnancy. A delay in the diagnosis mayincrease the patient's risk, and therefore the prompt identification of GTN isimportant.HCG test is essential for detection of GTN. False-positive hCG (phantomhCG) can occur in the absence of GTN. Low-level real hCG may occasionally persistin the absence of clinical evidence of pregnancy or GTD. Alternatively, low-level realhCG may be due to pituitary hCG.CONCLUSION: hCG has high diagnostic sensitivity, approaching 100%sensitivity, for managing the treatment of GTN and for detecting recurrences ofdisease. It is recommended to use hCG test that recognizes all forms of the hCGmolecule. In cases where low-level hCG persists, it must be differentiated whether itis real or false. Real-hCG may be due to quiescent gestational trophoblastic disease orpituitary hCG.Keywords: Human chorionic gonadotrophin (hCG), Gestational trophoblasticneoplasia (GTN), phantom hCG.52
53ABSTRACTSThe 1 st International Congress on Gynecological OncologyAssessment of Gross Examination and Frozen Sectionof Uterine Specimen in Endometrial Cancer PatientsFatemeh Ghaemmaghami, Soheila Aminimoghaddam, Mitra Modares-Gilani,Azamosadat Mousavi, Zahra Khazaeipour, Forozandeh FereidoniGynecology Oncology Department, Vali-e-Asr Hospital Comlex, Tehran Universityof Medical SciencesAbstract:Objective: The accuracy of Intra-operative gross visual examination of myometrialinvasion of uterine specimen has been evaluated in several studies with controversialresults. The intra-operative frozen section (IFS) analysis is used to identify patients athigh risk for pelvic and para-aortic nodal metastasis in order to avoidlymphadenectomy in low -risk patients. However, there is still some controversyconcerning the efficiency of IFS. The aim of this study was to evaluate the accuracyand validity of frozen section diagnosis and gross examination of uterine specimencompared to the final histological results in patients with endometrial cancer.Methods: The study group comprised 31 patients with a pre-operativehistopathological diagnosis of endometrial carcinoma. Comprehensive surgicalstaging was performed in all patients. Intra-operative gross examination of the uterinecavity and wall with frozen section analysis was performed. Lymphadencetomy wasperformed in all patients. After frozen section analysis, the uterus together withremoved lymph nodes was stored and subjected to final pathologic diagnosis.Results: Gross examination accurately identified microscopic invasion ofmyometrium in 86.6% of the patients with 88.9% sensitivity, 85.7% specificity andnegative and positive predicative values of 72.7 and 94.7%, respectively. The kappawas 0.70(p
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ABSTRACTS<strong>The</strong> 1 st <strong>In</strong>ternational Congress on Gynecological Oncology52False Positive or Phantom hCG Result:A Serious Problem in GTN Follow-UpDr. Tahereh AshrafganjooeiAssociate Pr<strong>of</strong>essor, fellow <strong>of</strong> Gynecologic Oncology Department <strong>of</strong> Gynecology,Shahid Beheshti Medical UniversityGynecology oncology Department, Emam Hosein hospital, Shahid Madani Street,Tehran, IranPhone number: 0098-21-77558081dr _ ganjooei@hotmail.comBackground: Gestational trophoblastic neoplasia (GTN) refers to a subset <strong>of</strong> GTDwith a persistently elevated serum hCG in <strong>the</strong> absence <strong>of</strong> a normal pregnancy andwith a history <strong>of</strong> normal or abnormal pregnancy. A delay in <strong>the</strong> diagnosis mayincrease <strong>the</strong> patient's risk, and <strong>the</strong>refore <strong>the</strong> prompt identification <strong>of</strong> GTN isimportant.HCG test is essential for detection <strong>of</strong> GTN. False-positive hCG (phantomhCG) can occur in <strong>the</strong> absence <strong>of</strong> GTN. Low-level real hCG may occasionally persistin <strong>the</strong> absence <strong>of</strong> clinical evidence <strong>of</strong> pregnancy or GTD. Alternatively, low-level realhCG may be due to pituitary hCG.CONCLUSION: hCG has high diagnostic sensitivity, approaching 100%sensitivity, for managing <strong>the</strong> treatment <strong>of</strong> GTN and for detecting recurrences <strong>of</strong>disease. It is recommended to use hCG test that recognizes all forms <strong>of</strong> <strong>the</strong> hCGmolecule. <strong>In</strong> cases where low-level hCG persists, it must be differentiated whe<strong>the</strong>r itis real or false. Real-hCG may be due to quiescent gestational trophoblastic disease orpituitary hCG.Keywords: Human chorionic gonadotrophin (hCG), Gestational trophoblasticneoplasia (GTN), phantom hCG.52
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