Syllabus - The Swami Ramanand Teerth Marathwada University
Syllabus - The Swami Ramanand Teerth Marathwada University Syllabus - The Swami Ramanand Teerth Marathwada University
6. PRODRUG DESIGN 6 hrs Introduction, chemical bond, gastrointestinal absorption, parenteral administration, distribution, transdermal absorption, pharmacokinetics and biopharmaceutical aspects, rational of prodrug design and practical considerations HOME ASSIGNMENT � Recent advances and trends in the above mentioned categories of drugs. REFERENCES 1. Burger: Medicinal Chemistry series, John Wiley & Sons N.Y. 2. Foye: Principals of Medicinal Chemistry (Varghese & Co.) 3. Lednicer: Organic drug synthesis Vol.1,2,3,4; John Wiley & Sons N.Y. 4. Ariens: Medicinal Chemistry series. 5. Elies & West: Progress in Medicinal Chemistry series. 6. Wilson & Gisvold: Text book of Medicinal Chemistry, J. B. Lippin 7. Comprehensive Medicinal Chemistry series I-IV, Academic Press. 8. Combinational Chemistry-synthesis and applications- Stephen R. Wilson 9. Recent advances in chiral separations, Ed. Stevenson & Wi, Latest 1990, Plenum Press. 10. Chiral Technology, R. A. Steldon, Marcell Dekker Inc. New York. 11. Combinatorial Chemistry Ed. Fennirl Hicham 2000 Oxford University
Subject code : MPY - 223 Subject : DRUG DESIGN THEORY 60 Hours (4 hrs. /week) 1. DRUG DISCOVERY 5 hrs a. Historical Perspective b. Drug Discovery studies in Direct Drug Design( Structure based) ND Indirect Drug Design c. Target Selection and Lead Identification i) Natural Product Sources ii) Fermentation/ microbial sources iii) Synthetic d. Introduction to Pharmacogenomics. 2. APPROACHES TO THE RATIONAL DESIGN OF ENZYME INHIBITORS a. Introduction i) Enzyme inhibitors in Medicine ii) Enzyme inhibitors in basic Research iii) Drug Design based on Antagonism and Enzyme Inhibition 8 hrs b. Rational design of non covalently & covalently binding enzyme inhibitors Rapid reversible inhibitors, slow & tight binding inhibitors, Transition state analogs, multisubstrate inhibitors. 4. QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP 12 hrs a. History and development of QSAR b. Drug-Receptor Interactions c. Quantitative model parameters: lipophilicity, electronic and steric factors d. Hansch Analysis, Free Wilson analysis, relationship between them and their application. e. Statistical methods-regression analysis, partial-least square analysis (PLS) and other multivariate statistical methods f. 2D and 3D QSAR approaches
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6. PRODRUG DESIGN 6 hrs<br />
Introduction, chemical bond, gastrointestinal absorption, parenteral administration,<br />
distribution, transdermal absorption, pharmacokinetics and biopharmaceutical aspects,<br />
rational of prodrug design and practical considerations<br />
HOME ASSIGNMENT<br />
� Recent advances and trends in the above mentioned categories of drugs.<br />
REFERENCES<br />
1. Burger: Medicinal Chemistry series, John Wiley & Sons N.Y.<br />
2. Foye: Principals of Medicinal Chemistry (Varghese & Co.)<br />
3. Lednicer: Organic drug synthesis Vol.1,2,3,4; John Wiley & Sons N.Y.<br />
4. Ariens: Medicinal Chemistry series.<br />
5. Elies & West: Progress in Medicinal Chemistry series.<br />
6. Wilson & Gisvold: Text book of Medicinal Chemistry, J. B. Lippin<br />
7. Comprehensive Medicinal Chemistry series I-IV, Academic Press.<br />
8. Combinational Chemistry-synthesis and applications- Stephen R.<br />
Wilson<br />
9. Recent advances in chiral separations, Ed. Stevenson & Wi, Latest<br />
1990, Plenum Press.<br />
10. Chiral Technology, R. A. Steldon, Marcell Dekker Inc. New York.<br />
11. Combinatorial Chemistry Ed. Fennirl Hicham 2000 Oxford <strong>University</strong>
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