Syllabus - The Swami Ramanand Teerth Marathwada University
Syllabus - The Swami Ramanand Teerth Marathwada University Syllabus - The Swami Ramanand Teerth Marathwada University
8. Clinical Pharmacokinetics, Concepts and Applications; By Malcolm Rowland and Thomas N.Tozer. Lea and Febiger, Philadelphia, 1995. 9. Dissolution, Bioavailability and Bioequivalence; By Abdou.H.M., Mack Publishing Company, Pennsylvania, 1989. 10. Biopharmaceutics and Clinical Pharmacokinetics- An introduction; 4th edition, Revised and expanded By Robert. E. Notari, Marcel Dekker Inc, New York and Basel, 1987. 11. Encyclopedia of Pharmaceutical Technology, Vol 13, James Swarbrick, James. C.Boylan. Marcel Dekker Inc, New York, 1996. Subject code : MPY-213 Subject : INDUSTRIAL PHARMACY THEORY 60 Hours (4 hrs. /week) 1. PREFORMULATION 10 Hours Introduction, organoleptic properties, purity, particle size, shape, and surface area. Solubilisation, surfactants and its importance, temperature, pH, co-solvency; Techniques for the study of crystal properties and polymorphism. Physicochemical characteristics of new drug molecules with respect to different dosage forms. 2. COMPACTION AND COMPRESSION 6 Hours Compaction of powders with particular reference to distribution and measurement of forces within the powder mass undergoing compression including- physics of tablet compression; Effect of particle size, moisture content, lubrication etc on strength of tablets. 3. OPTIMIZATION TECHNIQUES IN PHARMACEUTICAL FORMULATION AND PROCESSING 5 Hours Concept of optimization, Optimization parameters, Classical optimization, Statistical design, and Optimization methods. 4. PILOT PLANT SCALE UP TECHNIQUES 10 Hours Significance of pilot plant scale up study and large scale manufacturing techniques (formula, equipment, process, stability and quality control) of some important dosage
forms such as tablets, capsules, injections, liquid orals, semisolids, ophthalmic products, emulsions including multiple emulsions. 5. METHODS OF ENHANCING BIOAVAILABILITY 7 Hours Solubilization, Prodrugs, and enhancement of dissolution characteristics, cyclodextrin, permeation enhancer, solid dispersion, surfactant, bioavailability enhancers. 6. SURFACTANT SYSTEM 7 Hours Introduction, micellization, thermodynamics and kinetics of micelle formation, classification.,. Pharmaceutical aspects of Solubilization, Solubilization in non- aqueous system, interactions with polymers and oppositely charged species. Surfactants in emulsions and suspensions. drug absorption, antibacterial activity. HOME ASSIGNMENT: • Optimization & Pilot plant scale up techniques for Tablets & Capsules- an overview. • Automation & Effluent testing and Treatment in Pharmaceutical industries. • Industrial hazards- Monitoring and preventive systems (Safety measures) REFERENCE BOOKS: 1. Theory and Practice of Industrial Pharmacy By Lachmann and Libermann. 2. Pharmaceutical dosage forms: Tablets Vol. 1-3 by Leon Lachmann. 3. Pharmaceutical Dosage forms: Disperse systems, Vol, 1-2; By Leon Lachmann. 4. Pharmaceutical Dosage forms: Parenteral medications Vol. 1-2; Leon Lachmann. 5. Modern Pharmaceutics; By Gillbert and S. Banker. 6. Remington’s Pharmaceutical Sciences. 7. Advances in Pharmaceutical Sciences Vol. 1-5; By H.S. Bean & A.H. Beckett. 8. Physical Pharmacy; By Alfred martin 9. Bentley’s Textbook of Pharmaceutics – Rawbins. 10. Good manufacturing practices for Pharmaceuticals: A plan for total quality control, Second edition; By Sidney H. Willig.
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8. Clinical Pharmacokinetics, Concepts and Applications; By Malcolm Rowland and<br />
Thomas N.Tozer. Lea and Febiger, Philadelphia, 1995.<br />
9. Dissolution, Bioavailability and Bioequivalence; By Abdou.H.M., Mack Publishing<br />
Company, Pennsylvania, 1989.<br />
10. Biopharmaceutics and Clinical Pharmacokinetics- An introduction; 4th edition,<br />
Revised and expanded By Robert. E. Notari, Marcel Dekker Inc, New York and<br />
Basel, 1987.<br />
11. Encyclopedia of Pharmaceutical Technology, Vol 13, James Swarbrick, James.<br />
C.Boylan. Marcel Dekker Inc, New York, 1996.<br />
Subject code : MPY-213<br />
Subject : INDUSTRIAL PHARMACY<br />
THEORY 60 Hours (4 hrs. /week)<br />
1. PREFORMULATION 10 Hours<br />
Introduction, organoleptic properties, purity, particle size, shape, and surface area.<br />
Solubilisation, surfactants and its importance, temperature, pH, co-solvency;<br />
Techniques for the study of crystal properties and polymorphism. Physicochemical<br />
characteristics of new drug molecules with respect to different dosage forms.<br />
2. COMPACTION AND COMPRESSION 6 Hours<br />
Compaction of powders with particular reference to distribution and measurement of<br />
forces within the powder mass undergoing compression including- physics of tablet<br />
compression; Effect of particle size, moisture content, lubrication etc on strength of<br />
tablets.<br />
3. OPTIMIZATION TECHNIQUES IN PHARMACEUTICAL<br />
FORMULATION AND PROCESSING 5 Hours<br />
Concept of optimization, Optimization parameters, Classical optimization, Statistical<br />
design, and Optimization methods.<br />
4. PILOT PLANT SCALE UP TECHNIQUES 10 Hours<br />
Significance of pilot plant scale up study and large scale manufacturing techniques<br />
(formula, equipment, process, stability and quality control) of some important dosage
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