Mechanisms of aluminium neurotoxicity in oxidative stress-induced ...

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Don Ramón Soto Otero y Doña Estefanía Méndez Álvarez, profesores titulares del Departamento de Bioquímica y Biología Molecular de la Universidad de Santiago de Compostela, INFORMAN: Que la presente memoria titulada Estudio de los Mecanismos de Neurotoxicidad del Aluminio en Procesos Degenerativos por Estrés Oxidativo Relacionados con la Enfermedad de Parkinson, presentada por Doña Sofía Sánchez Iglesias para optar al grado de Doctor en Bioquímica, ha sido realizada bajo nuestra dirección en los Laboratorios del Departamento de Bioquímica y Biología Molecular de esta Universidad, y considerando que constituye trabajo de tesis y reúne los requisitos necesarios para ser valorado por el tribunal correspondiente, autorizamos su presentación al Consejo de Departamento correspondiente. Y para que así conste y surta los efectos oportunos, firmamos el presente informe en Santiago de Compostela a 15 de octubre de 2009. El Director de la Tesis La Directora de la Tesis Ramón Soto Otero Profesor titular Dpto. Bioquímica y Biología Molecular El Doctorando Sofía Sánchez Iglesias Estefanía Méndez Álvarez Profesora titular Dpto. Bioquímica y Biología Molecular
Page 1: Universidade de Santiago de Compost
Page 7: Esta Tesis Doctoral forma parte de
Page 10 and 11: Now life is not only science, I wou
Page 12 and 13: Abbreviations (continuation) GSSH o
Page 15 and 16: List of figures Introduction Figure
Page 17: List of tables Introduction Table 1
Page 20 and 21: Intranasal absorption .............
Page 23: INTRODUCTION
Page 26 and 27: INTRODUCTION 2 PD, also called idio
Page 28 and 29: INTRODUCTION Resting tremor 4 Resti
Page 30 and 31: INTRODUCTION disease, especially in
Page 32 and 33: INTRODUCTION diagnosis was substant
Page 34 and 35: INTRODUCTION Table 2: UK Parkinson
Page 36 and 37: INTRODUCTION Neurochemical and neur
Page 38 and 39: INTRODUCTION Figure 5: Dopamine pat
Page 40 and 41: INTRODUCTION accounting each for ap
Page 42 and 43: INTRODUCTION reduced activity in th
Page 44 and 45: INTRODUCTION Degeneration of all DA
Page 46 and 47: INTRODUCTION other brain areas and
Page 48 and 49: INTRODUCTION Figure 13: Six stages
Page 50 and 51: INTRODUCTION kinase 1 (PINK1) (Vale
Page 52 and 53: INTRODUCTION the drug users was fur
Page 54 and 55:
INTRODUCTION be largely discussed l
Page 56 and 57:
INTRODUCTION Parkinson diseases: a
Page 58 and 59:
INTRODUCTION Figure 18: The ubiquit
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INTRODUCTION Mitochondrial dysfunct
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INTRODUCTION Oxidative stress 38 Ox
Page 64 and 65:
INTRODUCTION Transition metals: the
Page 66 and 67:
INTRODUCTION Nitric oxide 42 There
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INTRODUCTION have also been demonst
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INTRODUCTION 46 Another pathway has
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INTRODUCTION Cell death pathways 48
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INTRODUCTION Although the 6-OHDA mo
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INTRODUCTION mouse models, such as
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INTRODUCTION and [Al13(OH)30] 9+ .
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INTRODUCTION Iatrogenic exposure 56
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INTRODUCTION et al. 1993), probably
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INTRODUCTION Coble 1987). Transderm
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INTRODUCTION Aluminium influx and e
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INTRODUCTION Aluminium and oxidativ
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INTRODUCTION (Kong et al. 2002). In
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INTRODUCTION 68 As mentioned before
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INTRODUCTION 70 The signal transduc
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AIMS
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AIMS Chapter 3 The third major aim
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OBJETIVOS DE LA PRESENTE TESIS OBJE
Page 105:
CHAPTER 1
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ABSTRACT CHAPTER 1 The unilateral a
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CHAPTER 1 2001), particularly due t
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Brain samples CHAPTER 1 After decap
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Statistical analysis CHAPTER 1 Resu
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CHAPTER 1 the left striatum and +11
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CHAPTER 1 against degeneration (Tro
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CHAPTER 1 Fig. 1 Changes in TBARS l
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CHAPTER 1 Fig. 3 Changes in PTC in
Page 127:
CHAPTER 2 Analysis of brain regiona
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CHAPTER 2 INTRODUCTION 106 Aluminiu
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CHAPTER 2 experimental period of fo
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CHAPTER 2 RESULTS Aluminium distrib
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CHAPTER 2 significant increase of t
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CHAPTER 3
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ABSTRACT CHAPTER 3 The ability of a
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CHAPTER 3 not undergo redox reactio
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CHAPTER 3 saline over the same peri
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CHAPTER 3 used as chemical dosimete
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Statistical analysis CHAPTER 3 Data
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CHAPTER 3 was noted in hippocampus
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CHAPTER 3 In vitro effects of alumi
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CHAPTER 3 administration routes (De
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CHAPTER 3 difference in the levels
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CHAPTER 3 Table 1. In vitro effects
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CHAPTER 3 139
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CHAPTER 3 141
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CHAPTER 3 Fig. 4 Density of striata
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CHAPTER 3 145
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CHAPTER 3 147
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SUMMARY SUMMARY Aluminium has becom
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SUMMARY stress is reached at this t
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CONCLUSIONS
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CONCLUSIONS 5) Intraperitoneal alum
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RESUMEN
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RESUMEN 1996, Shimohama et al. 2003
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RESUMEN 166 Por último y con el fi
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CONCLUSIONES CONCLUSIONES Los resul
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CONCLUSIONES aumento de grupos carb
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APPENDIX
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APPENDIX Publications arising from
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REFERENCES REFERENCES Aarts M., Liu
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REFERENCES Andersen J. K. (2004) Ox
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REFERENCES Beckman J. S. and Koppen
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REFERENCES Bonifati V., Rizzu P., v
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REFERENCES Cedarbaum J. M. and McDo
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REFERENCES Cooper J. R., Bloom F. E
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REFERENCES Deloncle R., Huguet E.,
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REFERENCES Döllken U. (1897) Ueber
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REFERENCES Exley C. (2004b) Aluminu
Page 221 and 222:
REFERENCES (2006) PINK1 protein in
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REFERENCES Glinka Y., Tipton K. F.
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REFERENCES Grune T., Jung T., Merke
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REFERENCES Hegde R., Srinivasula S.
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REFERENCES Hughes A. J., Ben-Shlomo
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REFERENCES Variable expression of P
Page 233 and 234:
REFERENCES Kalaitzakis M. E., Graeb
Page 235 and 236:
REFERENCES Klintworth H., Garden G.
Page 237 and 238:
REFERENCES Langston J. W. and Balla
Page 239 and 240:
REFERENCES Lione A. (1983) The prop
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REFERENCES Marti M. J., James C.J.,
Page 243 and 244:
REFERENCES Méndez-Álvarez E., Sot
Page 245 and 246:
REFERENCES Muller T., Blum-Degen D.
Page 247 and 248:
REFERENCES Nunes I., Tovmasian L. T
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REFERENCES Pappolla M. A. (1986) Le
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REFERENCES Papapetropoulos T., John
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REFERENCES Rajput A. H., Rozdilsky
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REFERENCES Roider G. and Drasch G.
Page 257 and 258:
REFERENCES toxicity demonstrates se
Page 259 and 260:
REFERENCES Sedelis M., Hofele K., A
Page 261 and 262:
REFERENCES Sjögren B., Elinder C.
Page 263 and 264:
REFERENCES Strassburger J. and Cobl
Page 265 and 266:
REFERENCES Tsang A. H. and Chung K.
Page 267 and 268:
REFERENCES Verstraeten S. V. (2000)
Page 269 and 270:
REFERENCES Walker V. R., Sutton R.
Page 271 and 272:
REFERENCES Yamamuro A., Yoshioka Y.
Page 273 and 274:
REFERENCES Zapatero M. D., Garcia d
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