Mechanisms of aluminium neurotoxicity in oxidative stress-induced ...

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REFERENCES Yokel R. A. (2002a) Aluminum chelation principles and recent advances. Coord. Chem. Rev. 248 228, 97–113. Yokel R. A. (2002b) Brain uptake, retention, and efflux of aluminum and manganese. Environ. Health Perspect. 110, 699–704. Yokel R. A. (2006) Blood-brain barrier flux of aluminum, manganese, iron and other metals suspected to contribute to metal-induced neurodegeneration. J. Alzheimers Dis. 10, 223– 253. Yokel R. A. and McNamara P. J. (1988) Influence of renal impairment, chemical form, and serum protein binding on intravenous and oral aluminum kinetics in the rabbit. Toxicol Appl Pharmacol. 95, 32-43. Yokel R. A. and McNamara P. J. (2001) Aluminium toxicokinetics: an updated minireview. Pharmacol. Toxicol. 88, 159–167. Yokel R. A. and O’Callaghan J. P. (1998) An aluminum-induced increase in GFAP is attenuated by some chelators. Neurotoxicol. and Teratol. 20, 55-60. Yokel R. A., Meurer K. A., Skinner T. L. and Fredenburg A. M. (1996) The 3-hydroxypyridin-4- ones more effectively chelate aluminum in a rabbit model of aluminum intoxication than does desferrioxamine. Drug Metab. Disp. 24, 105–111. Yokel R. A., Rhineheimer S. S., Brauer R. D., Sharma P., Elmore D. and McNamara P. J. (2001a) Aluminum bioavailability from drinking water is very low and is not appreciably influenced by stomach contents or water hardness. Toxicology 161, 93–101. Yokel R. A., Rhineheimer S. S., Sharma P., Elmore D. and McNamara P. J. (2001b) Entry, half- life, and desferrioxamine-accelerated clearance of brain aluminum after a single (26)Al exposure. Toxicol Sci. 64, 77–82. Youdim M. B. (1988) Iron in the brain: implications for Parkinson’s and Alzheimer’s diseases. Mt. Sinai J. Med. 55, 97–101.
REFERENCES Zapatero M. D., Garcia de Jalon A., Pascual F., Calvo M. L., Escanero J., Marro A. (1995) Serum aluminum levels in Alzheimer's disease and other senile dementias. Biol. Trace Elem. Res. 47, 235–240. Zarow C., Lyness S. A., Mortimer J. A. and Chui H. C. (2003) Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases. Arch. Neurol. 60, 337–341. Zatta P., Favarato M. and Nicolini M. (1993) Deposition of aluminum in brain tissues of rats exposed to inhalation of aluminum acetylacetonate. Neuroreport 4, 1119–1122. Zatta P., Kiss T., Suwalsky M. and Berthon G. (2002) Aluminium(III) as a promoter of cellular oxidation. Coord Chem. Rev. 228, 271–284. Zatta P., Lucchini R., van Rensburg S. J. and Taylor A. (2003) The role of metals in neurodegenerative processes: aluminum, manganese, and zinc. Brain Res. Bull. 62, 15–28. Zayed J., Ducic S., Campanella G., Panisset J. C., André P., Masson H. and Roy M. (1990) Environmental factors in the etiology of Parkinson's disease. Can. J. Neurol. Sci. 17, 286– 291. Zhang L., Shimoji M., Thomas B., Moore D. J., Yu S., Marupudi N. I., Torp R., Torgner I. A., Ottersen O. P., Dawson T. M. and Dawson V. L. (2005) Mitochondrial localisation of the Parkinson’s disease related protein DJ-1: implications for pathogenesis. Hum. Mol. Genet. 14, 2063–2073. Zhang Y., Dawson V. L. and Dawson T. M. (2000) Oxidative stress and genetics in the pathogenesis of Parkinson's disease. Neurobiol. Dis. 7, 240–250. Zheng W., Aschner M. and Ghersi-Egea J. F. (2003) Brain barrier systems: a new frontier in metal neurotoxicological research. Toxicol. Appl. Pharmacol. 192, 1–11. Zhou C., Huang Y., Shao Y., May J., Prou D., Perier C., Dauer W., Schon E. A. and Przedborski S. (2008) The kinase domain of mitochondrial PINK1 faces the cytoplasm. Proc. Natl. Acad. Sci. U. S. A. 105, 12022–12027. 249
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Universidade de Santiago de Compost
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Don Ramón Soto Otero y Doña Estef
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Acknowledgements The work of this t
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Abbreviations AA ascorbic acid AD A
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Abbreviations (continuation) PCC pr
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List of figures (continuation) Chap
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TABLE OF CONTENTS INTRODUCTION ....
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CHAPTER 3 Brain oxidative stress an
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INTRODUCTION PARKINSON’S DISEASE
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INTRODUCTION PD is found in all eth
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Bradykinesia INTRODUCTION Bradykine
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INTRODUCTION predate the occurrence
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Table 1: Differential diagnostic in
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INTRODUCTION Table 3: National Inst
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Figure 4: Dopamine catabolism (Mén
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The basal ganglia INTRODUCTION The
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The death of SNpc DAergic neurons I
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INTRODUCTION the dorsomedial part o
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INTRODUCTION characterized as are l
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INTRODUCTION (Olanow et al. 2004).
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Etiology and pathogenesis of PD INT
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Ageing INTRODUCTION Ageing remains
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INTRODUCTION The finding of MPTP to
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INTRODUCTION may clarify why many n
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Misfolding and aggregation of prote
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INTRODUCTION (E3) (Figure 18A). Los
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INTRODUCTION in connection with Par
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INTRODUCTION Oxidative damage happe
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DA metabolism as a source of ROS IN
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Contribution of oxidative and nitro
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Excitotoxicity INTRODUCTION Glutama
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INTRODUCTION al. 1996, Cicchetti et
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Experimental models of PD INTRODUCT
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INTRODUCTION induce selective DAerg
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ALUMINIUM General features INTRODUC
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INTRODUCTION Varying amounts of alu
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INTRODUCTION and antiperspirants co
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INTRODUCTION approximately 3% of al
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Excretion INTRODUCTION As insoluble
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INTRODUCTION 3.5 mg may be increase
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INTRODUCTION Oteiza 1999), non-iron
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Aluminium as a cell membrane menace
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INTRODUCTION mobilization of Ca 2+
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Aluminium impairs neurotransmission
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AIMS OF THE PRESENT THESIS The main
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OBJETIVOS
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OBJETIVOS 3) Evaluar de forma preci
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CHAPTER 1 Time-course of brain oxid
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CHAPTER 1 INTRODUCTION 86 6-OHDA (2
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CHAPTER 1 MATERIALS AND METHODS Che
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CHAPTER 1 followed by centrifugatio
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CHAPTER 1 RESULTS Effects of 6-OHDA
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CHAPTER 1 DISCUSSION 94 As shown by
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CHAPTER 1 strategies or to study th
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CHAPTER 1 Fig. 2 Changes in PCC in
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CHAPTER 2
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ABSTRACT CHAPTER 2 In the present w
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MATERIALS AND METHODS Chemicals CHA
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CHAPTER 2 atomization used were 1,5
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DISCUSSION CHAPTER 2 Aluminium ente
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Table 1. Graphite furnace programme
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CHAPTER 3 Brain oxidative stress an
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CHAPTER 3 INTRODUCTION 120 The huma
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CHAPTER 3 MATERIALS AND METHODS Che
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CHAPTER 3 1:15 for hippocampus and
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CHAPTER 3 initially incorporated to
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CHAPTER 3 RESULTS In vivo effects o
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CHAPTER 3 Effects of aluminium admi
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CHAPTER 3 DISCUSSION 132 Aluminium
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CHAPTER 3 hippocampus, showed simil
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CHAPTER 3 assume that the distinct
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CHAPTER 3 Fig. 1 Levels of TBARS (A
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CHAPTER 3 Fig. 2 Enzyme activity of
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CHAPTER 3 Fig. 3 Microphotographs s
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CHAPTER 3 Fig. 5 Levels of TBARS (A
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CHAPTER 3 Fig. 6 In vitro effects o
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SUMMARY
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SUMMARY values were attained at 48
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SUMMARY neurodegeneration in the DA
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CONCLUSIONS The results obtained in
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13) Aluminium does affect neither M
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RESUMEN RESUMEN Desde el punto de v
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RESUMEN zonas cerebrales excepto en
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CONCLUSIONES
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CONCLUSIONES Capítulo 2 4) La admi
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CONCLUSIONES 172 En base a las conc
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Publications as a direct result fro
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REFERENCES
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REFERENCES Agil A., Duran R., Barre
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REFERENCES Baquet Z. C., Bickford P
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REFERENCES 184 1,2,3,6-tetrahydropy
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REFERENCES 186 compacta of the subs
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REFERENCES Chung K. K., Dawson V. L
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REFERENCES Davies K. J. (2001) Degr
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REFERENCES Dhillon A. S., Tarbutton
Page 218 and 219:
REFERENCES Ekstrand M. I., Falkenbe
Page 220 and 221:
REFERENCES Fleming S. M., Delville
Page 222 and 223: REFERENCES Ghribi O., Dewitt D. A.,
Page 224 and 225: REFERENCES Good P. F., Olanow C. W.
Page 226 and 227: REFERENCES Hamilton E. I., Miniski
Page 228 and 229: REFERENCES Hirsch E. C., Brandel J.
Page 230 and 231: REFERENCES Inden M., Kitamura Y., T
Page 232 and 233: REFERENCES Johnson V. J. and Sharma
Page 234 and 235: REFERENCES Kim W. G., Mohney R. P.,
Page 236 and 237: REFERENCES Kuhn W., Winkel R., Woit
Page 238 and 239: REFERENCES 214 K.D. and Polymeropou
Page 240 and 241: REFERENCES Maraganore D. M., Lesnic
Page 242 and 243: REFERENCES McCord J. M. and Fridovi
Page 244 and 245: REFERENCES Miu A. C. and Benga O. (
Page 246 and 247: REFERENCES Nair V. D., McNaught K.,
Page 248 and 249: REFERENCES Onyango I. G. (2008) Mit
Page 250 and 251: REFERENCES Perez F. A. and Palmiter
Page 252 and 253: REFERENCES Przedborski S. and Goldm
Page 254 and 255: REFERENCES Rifat S. L., Eastwood M.
Page 256 and 257: REFERENCES Rymar V. V., Sasseville
Page 258 and 259: REFERENCES Savory J., Herman M. M.
Page 260 and 261: REFERENCES Shimizu H., Mori T., Koy
Page 262 and 263: REFERENCES 238 the generation of hy
Page 264 and 265: REFERENCES Taylor G. A., Moore P. B
Page 266 and 267: REFERENCES Um J. W., Stichel-Gunkel
Page 268 and 269: REFERENCES Vila M. and Przedborski
Page 270 and 271: REFERENCES Whitehead M. W., Farrar
Page 274: REFERENCES Zhou W., Zhu M., Wilson
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