Mechanisms of aluminium neurotoxicity in oxidative stress-induced ...

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REFERENCES Whitehead M. W., Farrar G., Christie G. L., Blair J. A., Thompson R. P. and Powell J. J. (1997) 246 Mechanisms of aluminum absorption in rats. Am. J. Clin. Nutr. 65, 1446–1452. Whitton P. S. (2007) Inflammation as a causative factor in the aetiology of Parkinson's disease. Br. J. Pharmacol. 150, 963–976. Wilhelm M., Jäger D. E. and Ohnesorge F. K. (1990) Aluminium toxicokinetics. Pharmacol Toxicol. 66, 4-9. Wilms H., Rosenstiel P., Sievers J., Deuschl G., Zecca L. and Lucius R. (2003) Activation of microglia by human neuromelanin is NF-kappaB dependent and involves p38 mitogen- activated protein kinase: implications for Parkinson’s disease. FASEB J. 17, 500– 502. Winogrodzka A., Bergmans P., Booij J., van Royen E. A., Janssen A. G., Wolters E. C. (2001) [123I]FP-CIT SPECT is a useful method to monitor the rate of dopaminergic degeneration in early-stage Parkinson’s disease. J. Neural. Transm. 108, 1011–1019. Wood-Kaczmar A., Gandhi S. and Wood N. W. (2006) Understanding the molecular causes of Parkinson’s disease. Trends Mol. Med. 12, 521–528. Wood-Kaczmar A., Gandhi S., Yao Z., Abramov A. S., Miljan E. A., Keen G., Stanyer L., Hargreaves I., Klupsch K., Deas E., Downward J., Mansfield L., Jat P., Taylor J., Heales S., Duchen M. R., Latchman D., Tabrizi S. J. and Wood N. W. (2008) PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons. PLoS ONE 3, e2455. World Health Organization (WHO) (1997) Aluminium. Geneva, World Health Organization, International Programme on Chemical Safety (Environmental Health Criteria 194). Xiong H., Wang D., Chen L., Choo Y. S., Ma H., Tang C., Xia K., Jiang W., Ronai Z., Zhuang X. and Zhang Z. (2009) Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. J. Clin. Invest. 119, 650–660. Yamaguchi H. and Shen J. (2007) Absence of dopaminergic neuronal degeneration and oxidative damage in aged DJ-1-deficient mice. Mol. Neurodegener. 2, 10.
REFERENCES Yamamuro A., Yoshioka Y., Ogita K. and Maeda S. (2006) Involvement of endoplasmic reticulum stress on the cell death induced by 6-hydroxydopamine in human neuroblastoma SH-SY5Y cells. Neurochem. Res. 31, 657–664. Yang E. Y., Guo-Ross S. X. and Bondy S. C. (1999) The stabilization of ferrous iron by a toxic beta-amyloid fragment and by an aluminum salt. Brain Res. 839, 221-226. Yang Y., Gehrke S., Imai Y., Huang Z., Ouyang Y., Wang J. W., Yang L., Beal M. F., Vogel H. and Lu B. (2006) Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin. Proc. Natl. Acad. Sci. U. S. A. 103, 10793–10798. Yang W., Chen L., Ding Y., Zhuang X. and Kang U. J. (2007) Paraquat induces dopaminergic dysfunction and proteasome impairment in DJ-1-deficient mice. Hum. Mol. Genet. 16, 2900–2910. Yang Y. X., Wood N. W. and Latchman D. S. (2009) Molecular basis of Parkinson's disease. Neuroreport 20, 150–156. Yao D., Gu Z., Nakamura T., Shi Z. Q., Ma Y., Gaston B., Palmer L. A., Rockenstein E. M., Zhang Z., Masliah E., Uehara T. and Lipton S. A. (2004) Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity. Proc. Natl. Acad. Sci. U. S. A. 101, 10810–10814. Yasui M., Kihira T. and Ota K. (1992) Calcium, magnesium and aluminum concentrations in Parkinson's disease. Neurotoxicology 13, 593-600. Yazdani U., German D. C., Liang C. L., Manzino L., Sonsalla P. K. and Zeevalk G. D. (2006) Rat model of Parkinson’s disease: Chronic central delivery of 1-methyl-4-phenylpyridinium (MPP + ). Exp. Neurol. 200, 172–183. Yokel R. A. (2000) The toxicology of aluminum in the brain: a review. Neurotoxicology 21, 813– 828. 247
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Universidade de Santiago de Compost
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Don Ramón Soto Otero y Doña Estef
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Acknowledgements The work of this t
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Abbreviations AA ascorbic acid AD A
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Abbreviations (continuation) PCC pr
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List of figures (continuation) Chap
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TABLE OF CONTENTS INTRODUCTION ....
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CHAPTER 3 Brain oxidative stress an
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INTRODUCTION PARKINSON’S DISEASE
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INTRODUCTION PD is found in all eth
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Bradykinesia INTRODUCTION Bradykine
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INTRODUCTION predate the occurrence
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Table 1: Differential diagnostic in
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INTRODUCTION Table 3: National Inst
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Figure 4: Dopamine catabolism (Mén
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The basal ganglia INTRODUCTION The
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The death of SNpc DAergic neurons I
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INTRODUCTION the dorsomedial part o
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INTRODUCTION characterized as are l
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INTRODUCTION (Olanow et al. 2004).
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Etiology and pathogenesis of PD INT
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Ageing INTRODUCTION Ageing remains
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INTRODUCTION The finding of MPTP to
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INTRODUCTION may clarify why many n
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Misfolding and aggregation of prote
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INTRODUCTION (E3) (Figure 18A). Los
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INTRODUCTION in connection with Par
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INTRODUCTION Oxidative damage happe
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DA metabolism as a source of ROS IN
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Contribution of oxidative and nitro
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Excitotoxicity INTRODUCTION Glutama
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INTRODUCTION al. 1996, Cicchetti et
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Experimental models of PD INTRODUCT
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INTRODUCTION induce selective DAerg
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ALUMINIUM General features INTRODUC
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INTRODUCTION Varying amounts of alu
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INTRODUCTION and antiperspirants co
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INTRODUCTION approximately 3% of al
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Excretion INTRODUCTION As insoluble
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INTRODUCTION 3.5 mg may be increase
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INTRODUCTION Oteiza 1999), non-iron
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Aluminium as a cell membrane menace
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INTRODUCTION mobilization of Ca 2+
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Aluminium impairs neurotransmission
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AIMS OF THE PRESENT THESIS The main
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OBJETIVOS
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OBJETIVOS 3) Evaluar de forma preci
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CHAPTER 1 Time-course of brain oxid
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CHAPTER 1 INTRODUCTION 86 6-OHDA (2
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CHAPTER 1 MATERIALS AND METHODS Che
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CHAPTER 1 followed by centrifugatio
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CHAPTER 1 RESULTS Effects of 6-OHDA
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CHAPTER 1 DISCUSSION 94 As shown by
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CHAPTER 1 strategies or to study th
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CHAPTER 1 Fig. 2 Changes in PCC in
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CHAPTER 2
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ABSTRACT CHAPTER 2 In the present w
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MATERIALS AND METHODS Chemicals CHA
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CHAPTER 2 atomization used were 1,5
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DISCUSSION CHAPTER 2 Aluminium ente
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Table 1. Graphite furnace programme
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CHAPTER 3 Brain oxidative stress an
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CHAPTER 3 INTRODUCTION 120 The huma
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CHAPTER 3 MATERIALS AND METHODS Che
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CHAPTER 3 1:15 for hippocampus and
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CHAPTER 3 initially incorporated to
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CHAPTER 3 RESULTS In vivo effects o
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CHAPTER 3 Effects of aluminium admi
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CHAPTER 3 DISCUSSION 132 Aluminium
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CHAPTER 3 hippocampus, showed simil
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CHAPTER 3 assume that the distinct
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CHAPTER 3 Fig. 1 Levels of TBARS (A
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CHAPTER 3 Fig. 2 Enzyme activity of
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CHAPTER 3 Fig. 3 Microphotographs s
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CHAPTER 3 Fig. 5 Levels of TBARS (A
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CHAPTER 3 Fig. 6 In vitro effects o
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SUMMARY
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SUMMARY values were attained at 48
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SUMMARY neurodegeneration in the DA
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CONCLUSIONS The results obtained in
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13) Aluminium does affect neither M
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RESUMEN RESUMEN Desde el punto de v
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RESUMEN zonas cerebrales excepto en
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CONCLUSIONES
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CONCLUSIONES Capítulo 2 4) La admi
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CONCLUSIONES 172 En base a las conc
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Publications as a direct result fro
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REFERENCES
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REFERENCES Agil A., Duran R., Barre
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REFERENCES Baquet Z. C., Bickford P
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REFERENCES 184 1,2,3,6-tetrahydropy
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REFERENCES 186 compacta of the subs
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REFERENCES Chung K. K., Dawson V. L
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REFERENCES Davies K. J. (2001) Degr
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REFERENCES Dhillon A. S., Tarbutton
Page 218 and 219:
REFERENCES Ekstrand M. I., Falkenbe
Page 220 and 221: REFERENCES Fleming S. M., Delville
Page 222 and 223: REFERENCES Ghribi O., Dewitt D. A.,
Page 224 and 225: REFERENCES Good P. F., Olanow C. W.
Page 226 and 227: REFERENCES Hamilton E. I., Miniski
Page 228 and 229: REFERENCES Hirsch E. C., Brandel J.
Page 230 and 231: REFERENCES Inden M., Kitamura Y., T
Page 232 and 233: REFERENCES Johnson V. J. and Sharma
Page 234 and 235: REFERENCES Kim W. G., Mohney R. P.,
Page 236 and 237: REFERENCES Kuhn W., Winkel R., Woit
Page 238 and 239: REFERENCES 214 K.D. and Polymeropou
Page 240 and 241: REFERENCES Maraganore D. M., Lesnic
Page 242 and 243: REFERENCES McCord J. M. and Fridovi
Page 244 and 245: REFERENCES Miu A. C. and Benga O. (
Page 246 and 247: REFERENCES Nair V. D., McNaught K.,
Page 248 and 249: REFERENCES Onyango I. G. (2008) Mit
Page 250 and 251: REFERENCES Perez F. A. and Palmiter
Page 252 and 253: REFERENCES Przedborski S. and Goldm
Page 254 and 255: REFERENCES Rifat S. L., Eastwood M.
Page 256 and 257: REFERENCES Rymar V. V., Sasseville
Page 258 and 259: REFERENCES Savory J., Herman M. M.
Page 260 and 261: REFERENCES Shimizu H., Mori T., Koy
Page 262 and 263: REFERENCES 238 the generation of hy
Page 264 and 265: REFERENCES Taylor G. A., Moore P. B
Page 266 and 267: REFERENCES Um J. W., Stichel-Gunkel
Page 268 and 269: REFERENCES Vila M. and Przedborski
Page 272 and 273: REFERENCES Yokel R. A. (2002a) Alum
Page 274: REFERENCES Zhou W., Zhu M., Wilson
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