Mechanisms of aluminium neurotoxicity in oxidative stress-induced ...

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REFERENCES Perez F. A. and Palmiter R. D. (2005) Parkin-deficient mice are not a robust model of 226 parkinsonism. Proc. Natl. Acad. Sci. U. S. A. 102, 2174–2179. Perl D. P. and Brody A. R. (1980) Alzheimer's disease: X-ray spectrometric evidence of aluminum accumulation in neurofibrillary tangle-bearing neurons. Science 208, 297–299. Perl D. P. and Good P. F. (1987) Uptake of aluminium into central nervous system along nasal- olfactory pathways. Lancet 1, 1028. Perl D. P., Gajdusek D. C., Garruto R. M., Yanagihara R. T. and Gibbs C. J. (1982) Intraneuronal aluminum accumulation in amyotrophic lateral sclerosis and Parkinsonism-dementia of Guam. Science 217, 1053–1055. Petroske E., Meredith G. E., Callen S., Totterdell S. and Lau Y. S. (2001) Mouse model of Parkinsonism: a comparison between subacute MPTP and chronic MPTP/probenecid treatment. Neuroscience 106, 589–601. Piccini P. and Brooks D. J. (2006) New developments of brain imaging for Parkinson’s disease and related disorders. Mov. Disord. 21, 2035–2041. Platt B., Fiddler G., Riedel G. and Henderson Z. (2001) Aluminium toxicity in the rat brain: histochemical and immunocytochemical evidence. Brain Res. Bull. 55, 257–267. Plun-Favreau H., Klupsch K., Moisoi N., Gandhi S., Kjaer S., Frith D., Harvey K., Deas E., Harvey R. J., McDonald N., Wood N. W., Martins L. M. and Downward J. (2007) The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1. Nat. Cell. Biol. 9, 1243–1252. Poewe W. H. and Wenning G. K. (1998) The natural history of Parkinson’s disease. Ann. Neurol. 44, S1–S9. Poewe W. (2008) Non-motor symptoms in Parkinson's disease. Eur. J. Neurol. 15, 14–20. Polymeropoulos M. H., Lavedan C., Leroy E., Ide S. E., Dehejia A., Dutra A., Pike B., Root H., Rubenstein J., Boyer R., Stenroos E. S., Chandrasekharappa S., Athanassiadou A.,
REFERENCES Papapetropoulos T., Johnson W. G., Lazzarini A. M., Duvoisin R. C., Di Iorio G., Golbe L. I. and Nussbaum R. L. (1997) Mutation in the alpha-synuclein gene identified in families with Parkinson’s disease. Science 276, 2045–2047. Potthoff M. J. and Olson E. N. (2007) MEF2: a central regulator of diverse developmental programs. Development 134, 4131–4140. Powell J. J. and Thompson R. P. (1993) The chemistry of aluminium in the gastrointestinal lumen and its uptake and absorption. Proc. Nutr. Soc. 52, 241–253. Powell J. J., Greenfield S. M., Parkes H. G., Nicholson J. K. and Thompson R. P. (1993) Gastro- intestinal availability of aluminium from tea. Food Chem. Toxicol. 31, 449–454. Price K. S., Farley I. J. and Hornykiewicz O. (1978) Neurochemistry of Parkinson’s disease: relation between striatal and limbic dopamine. Adv. Biochem. Psychopharmacol. 19, 293– 300. Priest N. D. (2004) The biological behaviour and bioavailability of aluminium in man, with special reference to studies employing aluminium-26 as a tracer: review and study update. J. Environ. Monit. 6, 375–403. Priest N. D., Newton D., Day J. P., Talbot R. J. and Warner A. J. (1995) Human metabolism of aluminium-26 and gallium-67 injected as citrates. Hum. Exp. Toxicol. 14, 287–293. Przedborski S., Levivier M., Jiang H., Ferreira M., Jackson-Lewis V., Donaldson D. and Togasaki D. M. (1995) Dose-dependent lesions of the dopaminergic nigrostriatal pathway induced by intrastriatal injection of 6-hydroxydopamine. Neuroscience 67, 631–647. Priyadarshi A., Khuder S. A., Schaub E. A. and Priyadarshi S. S. (2001) Environmental risk factors and Parkinson’s disease: a metaanalysis. Environ. Res. 86, 122–127. Probst A., Bloch A. and Tolnay M. (2008) New insights into the pathology of Parkinson’s disease: does the peripheral system become central? Eur. J. Neurol. 15, 1–4. 227
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Universidade de Santiago de Compost
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Don Ramón Soto Otero y Doña Estef
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Acknowledgements The work of this t
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Abbreviations AA ascorbic acid AD A
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Abbreviations (continuation) PCC pr
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List of figures (continuation) Chap
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TABLE OF CONTENTS INTRODUCTION ....
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CHAPTER 3 Brain oxidative stress an
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INTRODUCTION PARKINSON’S DISEASE
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INTRODUCTION PD is found in all eth
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Bradykinesia INTRODUCTION Bradykine
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INTRODUCTION predate the occurrence
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Table 1: Differential diagnostic in
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INTRODUCTION Table 3: National Inst
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Figure 4: Dopamine catabolism (Mén
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The basal ganglia INTRODUCTION The
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The death of SNpc DAergic neurons I
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INTRODUCTION the dorsomedial part o
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INTRODUCTION characterized as are l
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INTRODUCTION (Olanow et al. 2004).
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Etiology and pathogenesis of PD INT
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Ageing INTRODUCTION Ageing remains
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INTRODUCTION The finding of MPTP to
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INTRODUCTION may clarify why many n
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Misfolding and aggregation of prote
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INTRODUCTION (E3) (Figure 18A). Los
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INTRODUCTION in connection with Par
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INTRODUCTION Oxidative damage happe
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DA metabolism as a source of ROS IN
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Contribution of oxidative and nitro
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Excitotoxicity INTRODUCTION Glutama
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INTRODUCTION al. 1996, Cicchetti et
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Experimental models of PD INTRODUCT
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INTRODUCTION induce selective DAerg
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ALUMINIUM General features INTRODUC
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INTRODUCTION Varying amounts of alu
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INTRODUCTION and antiperspirants co
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INTRODUCTION approximately 3% of al
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Excretion INTRODUCTION As insoluble
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INTRODUCTION 3.5 mg may be increase
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INTRODUCTION Oteiza 1999), non-iron
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Aluminium as a cell membrane menace
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INTRODUCTION mobilization of Ca 2+
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Aluminium impairs neurotransmission
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AIMS OF THE PRESENT THESIS The main
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OBJETIVOS
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OBJETIVOS 3) Evaluar de forma preci
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CHAPTER 1 Time-course of brain oxid
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CHAPTER 1 INTRODUCTION 86 6-OHDA (2
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CHAPTER 1 MATERIALS AND METHODS Che
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CHAPTER 1 followed by centrifugatio
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CHAPTER 1 RESULTS Effects of 6-OHDA
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CHAPTER 1 DISCUSSION 94 As shown by
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CHAPTER 1 strategies or to study th
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CHAPTER 1 Fig. 2 Changes in PCC in
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CHAPTER 2
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ABSTRACT CHAPTER 2 In the present w
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MATERIALS AND METHODS Chemicals CHA
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CHAPTER 2 atomization used were 1,5
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DISCUSSION CHAPTER 2 Aluminium ente
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Table 1. Graphite furnace programme
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CHAPTER 3 Brain oxidative stress an
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CHAPTER 3 INTRODUCTION 120 The huma
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CHAPTER 3 MATERIALS AND METHODS Che
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CHAPTER 3 1:15 for hippocampus and
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CHAPTER 3 initially incorporated to
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CHAPTER 3 RESULTS In vivo effects o
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CHAPTER 3 Effects of aluminium admi
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CHAPTER 3 DISCUSSION 132 Aluminium
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CHAPTER 3 hippocampus, showed simil
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CHAPTER 3 assume that the distinct
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CHAPTER 3 Fig. 1 Levels of TBARS (A
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CHAPTER 3 Fig. 2 Enzyme activity of
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CHAPTER 3 Fig. 3 Microphotographs s
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CHAPTER 3 Fig. 5 Levels of TBARS (A
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CHAPTER 3 Fig. 6 In vitro effects o
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SUMMARY
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SUMMARY values were attained at 48
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SUMMARY neurodegeneration in the DA
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CONCLUSIONS The results obtained in
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13) Aluminium does affect neither M
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RESUMEN RESUMEN Desde el punto de v
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RESUMEN zonas cerebrales excepto en
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CONCLUSIONES
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CONCLUSIONES Capítulo 2 4) La admi
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CONCLUSIONES 172 En base a las conc
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Page 204 and 205: REFERENCES Agil A., Duran R., Barre
Page 206 and 207: REFERENCES Baquet Z. C., Bickford P
Page 208 and 209: REFERENCES 184 1,2,3,6-tetrahydropy
Page 210 and 211: REFERENCES 186 compacta of the subs
Page 212 and 213: REFERENCES Chung K. K., Dawson V. L
Page 214 and 215: REFERENCES Davies K. J. (2001) Degr
Page 216 and 217: REFERENCES Dhillon A. S., Tarbutton
Page 218 and 219: REFERENCES Ekstrand M. I., Falkenbe
Page 220 and 221: REFERENCES Fleming S. M., Delville
Page 222 and 223: REFERENCES Ghribi O., Dewitt D. A.,
Page 224 and 225: REFERENCES Good P. F., Olanow C. W.
Page 226 and 227: REFERENCES Hamilton E. I., Miniski
Page 228 and 229: REFERENCES Hirsch E. C., Brandel J.
Page 230 and 231: REFERENCES Inden M., Kitamura Y., T
Page 232 and 233: REFERENCES Johnson V. J. and Sharma
Page 234 and 235: REFERENCES Kim W. G., Mohney R. P.,
Page 236 and 237: REFERENCES Kuhn W., Winkel R., Woit
Page 238 and 239: REFERENCES 214 K.D. and Polymeropou
Page 240 and 241: REFERENCES Maraganore D. M., Lesnic
Page 242 and 243: REFERENCES McCord J. M. and Fridovi
Page 244 and 245: REFERENCES Miu A. C. and Benga O. (
Page 246 and 247: REFERENCES Nair V. D., McNaught K.,
Page 248 and 249: REFERENCES Onyango I. G. (2008) Mit
Page 252 and 253: REFERENCES Przedborski S. and Goldm
Page 254 and 255: REFERENCES Rifat S. L., Eastwood M.
Page 256 and 257: REFERENCES Rymar V. V., Sasseville
Page 258 and 259: REFERENCES Savory J., Herman M. M.
Page 260 and 261: REFERENCES Shimizu H., Mori T., Koy
Page 262 and 263: REFERENCES 238 the generation of hy
Page 264 and 265: REFERENCES Taylor G. A., Moore P. B
Page 266 and 267: REFERENCES Um J. W., Stichel-Gunkel
Page 268 and 269: REFERENCES Vila M. and Przedborski
Page 270 and 271: REFERENCES Whitehead M. W., Farrar
Page 272 and 273: REFERENCES Yokel R. A. (2002a) Alum
Page 274: REFERENCES Zhou W., Zhu M., Wilson
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