Mechanisms of aluminium neurotoxicity in oxidative stress-induced ...
Mechanisms of aluminium neurotoxicity in oxidative stress-induced ... Mechanisms of aluminium neurotoxicity in oxidative stress-induced ...
CHAPTER 3 Brain oxidative stress and selective behaviour of aluminium in specific areas of rat brain: potential effects in a 6-OHDA-induced model of Parkinson’s disease Sofía Sánchez-Iglesias,* Estefanía Méndez-Álvarez,* , § Javier Iglesias- González,* Ana Muñoz-Patiño,† , § Inés Sánchez-Sellero,‡ José Luís Labandeira-García,† , § and Ramón Soto-Otero,* , § *Laboratory of Neurochemistry, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain †Laboratory of Neuroanatomy and Experimental Neurology, Department of Morphological Sciences, Faculty of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain ‡Department of Pathological Anatomy and Forensic Sciences, Faculty of Veterinary Medicine, University of Santiago de Compostela, Lugo, Spain §Networking Research Center on Neurodegenerative Diseases (CIBERNED), Spain J. Neurochem. (2009) 109, 879–888. 117
- Page 89 and 90: INTRODUCTION Oteiza 1999), non-iron
- Page 91 and 92: Aluminium as a cell membrane menace
- Page 93 and 94: INTRODUCTION mobilization of Ca 2+
- Page 95: Aluminium impairs neurotransmission
- Page 99 and 100: AIMS OF THE PRESENT THESIS The main
- Page 101: OBJETIVOS
- Page 104 and 105: OBJETIVOS 3) Evaluar de forma preci
- Page 107: CHAPTER 1 Time-course of brain oxid
- Page 110 and 111: CHAPTER 1 INTRODUCTION 86 6-OHDA (2
- Page 112 and 113: CHAPTER 1 MATERIALS AND METHODS Che
- Page 114 and 115: CHAPTER 1 followed by centrifugatio
- Page 116 and 117: CHAPTER 1 RESULTS Effects of 6-OHDA
- Page 118 and 119: CHAPTER 1 DISCUSSION 94 As shown by
- Page 120 and 121: CHAPTER 1 strategies or to study th
- Page 122 and 123: CHAPTER 1 Fig. 2 Changes in PCC in
- Page 125: CHAPTER 2
- Page 129 and 130: ABSTRACT CHAPTER 2 In the present w
- Page 131 and 132: MATERIALS AND METHODS Chemicals CHA
- Page 133 and 134: CHAPTER 2 atomization used were 1,5
- Page 135 and 136: DISCUSSION CHAPTER 2 Aluminium ente
- Page 137: Table 1. Graphite furnace programme
- Page 143 and 144: ABSTRACT CHAPTER 3 The ability of a
- Page 145 and 146: CHAPTER 3 not undergo redox reactio
- Page 147 and 148: CHAPTER 3 saline over the same peri
- Page 149 and 150: CHAPTER 3 used as chemical dosimete
- Page 151 and 152: Statistical analysis CHAPTER 3 Data
- Page 153 and 154: CHAPTER 3 was noted in hippocampus
- Page 155 and 156: CHAPTER 3 In vitro effects of alumi
- Page 157 and 158: CHAPTER 3 administration routes (De
- Page 159 and 160: CHAPTER 3 difference in the levels
- Page 161 and 162: CHAPTER 3 Table 1. In vitro effects
- Page 163 and 164: CHAPTER 3 139
- Page 165 and 166: CHAPTER 3 141
- Page 167 and 168: CHAPTER 3 Fig. 4 Density of striata
- Page 169 and 170: CHAPTER 3 145
- Page 171: CHAPTER 3 147
- Page 175 and 176: SUMMARY SUMMARY Aluminium has becom
- Page 177 and 178: SUMMARY stress is reached at this t
- Page 179: CONCLUSIONS
- Page 182 and 183: CONCLUSIONS 5) Intraperitoneal alum
- Page 185: RESUMEN
- Page 188 and 189: RESUMEN 1996, Shimohama et al. 2003
CHAPTER 3 Bra<strong>in</strong> <strong>oxidative</strong> <strong>stress</strong> and selective<br />
behaviour <strong>of</strong> <strong>alum<strong>in</strong>ium</strong> <strong>in</strong> specific areas <strong>of</strong> rat bra<strong>in</strong>: potential<br />
effects <strong>in</strong> a 6-OHDA-<strong>in</strong>duced model <strong>of</strong> Park<strong>in</strong>son’s disease<br />
S<strong>of</strong>ía Sánchez-Iglesias,* Estefanía Méndez-Álvarez,* , § Javier Iglesias-<br />
González,* Ana Muñoz-Patiño,† , § Inés Sánchez-Sellero,‡ José Luís<br />
Labandeira-García,† , § and Ramón Soto-Otero,* , §<br />
*Laboratory <strong>of</strong> Neurochemistry, Department <strong>of</strong> Biochemistry and Molecular Biology, Faculty <strong>of</strong> Medic<strong>in</strong>e,<br />
University <strong>of</strong> Santiago de Compostela, Santiago de Compostela, Spa<strong>in</strong><br />
†Laboratory <strong>of</strong> Neuroanatomy and Experimental Neurology, Department <strong>of</strong> Morphological Sciences,<br />
Faculty <strong>of</strong> Medic<strong>in</strong>e, University <strong>of</strong> Santiago de Compostela, Santiago de Compostela, Spa<strong>in</strong><br />
‡Department <strong>of</strong> Pathological Anatomy and Forensic Sciences, Faculty <strong>of</strong> Veter<strong>in</strong>ary Medic<strong>in</strong>e, University<br />
<strong>of</strong> Santiago de Compostela, Lugo, Spa<strong>in</strong><br />
§Network<strong>in</strong>g Research Center on Neurodegenerative Diseases (CIBERNED), Spa<strong>in</strong><br />
J. Neurochem. (2009) 109, 879–888.<br />
117
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