Mechanisms of aluminium neurotoxicity in oxidative stress-induced ...

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CHAPTER 3

Page 1: Universidade de Santiago de Compost

Page 5: Don Ramón Soto Otero y Doña Estef

Page 9 and 10: Acknowledgements The work of this t

Page 11 and 12: Abbreviations AA ascorbic acid AD A

Page 13: Abbreviations (continuation) PCC pr

Page 16 and 17: List of figures (continuation) Chap

Page 19 and 20: TABLE OF CONTENTS INTRODUCTION ....

Page 21: CHAPTER 3 Brain oxidative stress an

Page 25 and 26: INTRODUCTION PARKINSON’S DISEASE

Page 27 and 28: INTRODUCTION PD is found in all eth

Page 29 and 30: Bradykinesia INTRODUCTION Bradykine

Page 31 and 32: INTRODUCTION predate the occurrence

Page 33 and 34: Table 1: Differential diagnostic in

Page 35 and 36: INTRODUCTION Table 3: National Inst

Page 37 and 38: Figure 4: Dopamine catabolism (Mén

Page 39 and 40: The basal ganglia INTRODUCTION The

Page 41 and 42: The death of SNpc DAergic neurons I

Page 43 and 44: INTRODUCTION the dorsomedial part o

Page 45 and 46: INTRODUCTION characterized as are l

Page 47 and 48: INTRODUCTION (Olanow et al. 2004).

Page 49 and 50: Etiology and pathogenesis of PD INT

Page 51 and 52: Ageing INTRODUCTION Ageing remains

Page 53 and 54: INTRODUCTION The finding of MPTP to

Page 55 and 56: INTRODUCTION may clarify why many n

Page 57 and 58: Misfolding and aggregation of prote

Page 59 and 60: INTRODUCTION (E3) (Figure 18A). Los

Page 61 and 62: INTRODUCTION in connection with Par

Page 63 and 64: INTRODUCTION Oxidative damage happe

Page 65 and 66: DA metabolism as a source of ROS IN

Page 67 and 68: Contribution of oxidative and nitro

Page 69 and 70: Excitotoxicity INTRODUCTION Glutama

Page 71 and 72: INTRODUCTION al. 1996, Cicchetti et

Page 73 and 74: Experimental models of PD INTRODUCT

Page 75 and 76: INTRODUCTION induce selective DAerg

Page 77 and 78: ALUMINIUM General features INTRODUC

Page 79 and 80: INTRODUCTION Varying amounts of alu

Page 81 and 82: INTRODUCTION and antiperspirants co

Page 83 and 84: INTRODUCTION approximately 3% of al

Page 85 and 86: Excretion INTRODUCTION As insoluble

Page 87 and 88: INTRODUCTION 3.5 mg may be increase

Page 89 and 90: INTRODUCTION Oteiza 1999), non-iron

Page 91 and 92: Aluminium as a cell membrane menace

Page 93 and 94: INTRODUCTION mobilization of Ca 2+

Page 95: Aluminium impairs neurotransmission

Page 99 and 100: AIMS OF THE PRESENT THESIS The main

Page 101: OBJETIVOS

Page 104 and 105: OBJETIVOS 3) Evaluar de forma preci

Page 107: CHAPTER 1 Time-course of brain oxid

Page 110 and 111: CHAPTER 1 INTRODUCTION 86 6-OHDA (2

Page 112 and 113: CHAPTER 1 MATERIALS AND METHODS Che

Page 114 and 115: CHAPTER 1 followed by centrifugatio

Page 116 and 117: CHAPTER 1 RESULTS Effects of 6-OHDA

Page 118 and 119: CHAPTER 1 DISCUSSION 94 As shown by

Page 120 and 121: CHAPTER 1 strategies or to study th

Page 122 and 123: CHAPTER 1 Fig. 2 Changes in PCC in

Page 125: CHAPTER 2

Page 129 and 130: ABSTRACT CHAPTER 2 In the present w

Page 131 and 132: MATERIALS AND METHODS Chemicals CHA

Page 133 and 134: CHAPTER 2 atomization used were 1,5

Page 135 and 136: DISCUSSION CHAPTER 2 Aluminium ente

Page 137: Table 1. Graphite furnace programme

Page 143 and 144: ABSTRACT CHAPTER 3 The ability of a

Page 145 and 146: CHAPTER 3 not undergo redox reactio

Page 147 and 148: CHAPTER 3 saline over the same peri

Page 149 and 150: CHAPTER 3 used as chemical dosimete

Page 151 and 152: Statistical analysis CHAPTER 3 Data

Page 153 and 154: CHAPTER 3 was noted in hippocampus

Page 155 and 156: CHAPTER 3 In vitro effects of alumi

Page 157 and 158: CHAPTER 3 administration routes (De

Page 159 and 160: CHAPTER 3 difference in the levels

Page 161 and 162: CHAPTER 3 Table 1. In vitro effects

Page 163 and 164: CHAPTER 3 139


Page 167 and 168: CHAPTER 3 Fig. 4 Density of striata


Page 171: CHAPTER 3 147

Page 175 and 176: SUMMARY SUMMARY Aluminium has becom

Page 177 and 178: SUMMARY stress is reached at this t

Page 179: CONCLUSIONS

Page 182 and 183: CONCLUSIONS 5) Intraperitoneal alum

Page 185: RESUMEN

Page 188 and 189: RESUMEN 1996, Shimohama et al. 2003

Page 190 and 191: RESUMEN 166 Por último y con el fi

Page 193 and 194: CONCLUSIONES CONCLUSIONES Los resul

Page 195 and 196: CONCLUSIONES aumento de grupos carb

Page 197: APPENDIX

Page 200 and 201: APPENDIX Publications arising from

Page 203 and 204: REFERENCES REFERENCES Aarts M., Liu

Page 205 and 206: REFERENCES Andersen J. K. (2004) Ox

Page 207 and 208: REFERENCES Beckman J. S. and Koppen

Page 209 and 210: REFERENCES Bonifati V., Rizzu P., v

Page 211 and 212: REFERENCES Cedarbaum J. M. and McDo

Page 213 and 214: REFERENCES Cooper J. R., Bloom F. E

Page 215 and 216: REFERENCES Deloncle R., Huguet E.,

Page 217 and 218: REFERENCES Döllken U. (1897) Ueber

Page 219 and 220: REFERENCES Exley C. (2004b) Aluminu

Page 221 and 222: REFERENCES (2006) PINK1 protein in

Page 223 and 224: REFERENCES Glinka Y., Tipton K. F.

Page 225 and 226: REFERENCES Grune T., Jung T., Merke

Page 227 and 228: REFERENCES Hegde R., Srinivasula S.

Page 229 and 230: REFERENCES Hughes A. J., Ben-Shlomo

Page 231 and 232: REFERENCES Variable expression of P

Page 233 and 234: REFERENCES Kalaitzakis M. E., Graeb

Page 235 and 236: REFERENCES Klintworth H., Garden G.

Page 237 and 238: REFERENCES Langston J. W. and Balla

Page 239 and 240: REFERENCES Lione A. (1983) The prop

Page 241 and 242: REFERENCES Marti M. J., James C.J.,

Page 243 and 244: REFERENCES Méndez-Álvarez E., Sot

Page 245 and 246: REFERENCES Muller T., Blum-Degen D.

Page 247 and 248: REFERENCES Nunes I., Tovmasian L. T

Page 249 and 250: REFERENCES Pappolla M. A. (1986) Le

Page 251 and 252: REFERENCES Papapetropoulos T., John

Page 253 and 254: REFERENCES Rajput A. H., Rozdilsky

Page 255 and 256: REFERENCES Roider G. and Drasch G.

Page 257 and 258: REFERENCES toxicity demonstrates se

Page 259 and 260: REFERENCES Sedelis M., Hofele K., A

Page 261 and 262: REFERENCES Sjögren B., Elinder C.

Page 263 and 264: REFERENCES Strassburger J. and Cobl

Page 265 and 266: REFERENCES Tsang A. H. and Chung K.

Page 267 and 268: REFERENCES Verstraeten S. V. (2000)

Page 269 and 270: REFERENCES Walker V. R., Sutton R.

Page 271 and 272: REFERENCES Yamamuro A., Yoshioka Y.

Page 273 and 274: REFERENCES Zapatero M. D., Garcia d

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