Mechanisms of aluminium neurotoxicity in oxidative stress-induced ...
Mechanisms of aluminium neurotoxicity in oxidative stress-induced ... Mechanisms of aluminium neurotoxicity in oxidative stress-induced ...
Now life is not only science, I would therefore use this opportunity to thank my best friend Rosi for her patience and care during good and tough times in the Ph.D. pursuit. Always beside me. Finally, I would like to dedicate this work to my family: my grandmother Carmen and my grandfather Jesús always in my mind, my brother Jesús for his way of being, and very especially my parents María del Carmen and Alfonso for their unending love and support from ever. Thank you.
Abbreviations AA ascorbic acid AD Alzheimer’s disease ADH aldehyde dehydrogenase BBB blood-brain barrier BG basal ganglia BHT butylated hydroxytoluene BioH4 5,6,7,8-tetrahydrobiopterin BSA bovine serum albumine CaM calmodulin CAT catalase CBD corticobasal degeneration Cdk5 cyclin-dependent kinase 5 CMA chaperone mediated autophagy CNS central nervous system COMT catechol-O-methyl transferase COX-2 cyclooxygenase-2 CSF cerebrospinal fluid CT computarized tomography CySH cysteine DA 3-hydroxytyramine hydrochloride (dopamine) DAergic dopaminergic DAT dopamine transporter DES dialysis encephalopathy syndrome DLB dementia with Lewy bodies DMV dorsal motor nucleus of the vagus DOPAC dihydroxyphenylacetic acid DOPAL 3,4-dihydroxyphenylacetaldehyde eNOS endothelial nitric oxide synthase EOPD early onset of Parkinson’s disease ER endoplasmic reticulum FeBAD fetal basis of adult disease GABA �-aminobutyric acid GPCR G-protein coupled receptor GPe external globus pallidus GPi internal globus pallidus GPx glutathione peroxidase GR glutathione reductase GSH reduced glutathione
- Page 1: Universidade de Santiago de Compost
- Page 5: Don Ramón Soto Otero y Doña Estef
- Page 9: Acknowledgements The work of this t
- Page 13: Abbreviations (continuation) PCC pr
- Page 16 and 17: List of figures (continuation) Chap
- Page 19 and 20: TABLE OF CONTENTS INTRODUCTION ....
- Page 21: CHAPTER 3 Brain oxidative stress an
- Page 25 and 26: INTRODUCTION PARKINSON’S DISEASE
- Page 27 and 28: INTRODUCTION PD is found in all eth
- Page 29 and 30: Bradykinesia INTRODUCTION Bradykine
- Page 31 and 32: INTRODUCTION predate the occurrence
- Page 33 and 34: Table 1: Differential diagnostic in
- Page 35 and 36: INTRODUCTION Table 3: National Inst
- Page 37 and 38: Figure 4: Dopamine catabolism (Mén
- Page 39 and 40: The basal ganglia INTRODUCTION The
- Page 41 and 42: The death of SNpc DAergic neurons I
- Page 43 and 44: INTRODUCTION the dorsomedial part o
- Page 45 and 46: INTRODUCTION characterized as are l
- Page 47 and 48: INTRODUCTION (Olanow et al. 2004).
- Page 49 and 50: Etiology and pathogenesis of PD INT
- Page 51 and 52: Ageing INTRODUCTION Ageing remains
- Page 53 and 54: INTRODUCTION The finding of MPTP to
- Page 55 and 56: INTRODUCTION may clarify why many n
- Page 57 and 58: Misfolding and aggregation of prote
- Page 59 and 60: INTRODUCTION (E3) (Figure 18A). Los
Abbreviations<br />
AA ascorbic acid<br />
AD Alzheimer’s disease<br />
ADH aldehyde dehydrogenase<br />
BBB blood-bra<strong>in</strong> barrier<br />
BG basal ganglia<br />
BHT butylated hydroxytoluene<br />
BioH4<br />
5,6,7,8-tetrahydrobiopter<strong>in</strong><br />
BSA bov<strong>in</strong>e serum album<strong>in</strong>e<br />
CaM calmodul<strong>in</strong><br />
CAT catalase<br />
CBD corticobasal degeneration<br />
Cdk5 cycl<strong>in</strong>-dependent k<strong>in</strong>ase 5<br />
CMA chaperone mediated autophagy<br />
CNS central nervous system<br />
COMT catechol-O-methyl transferase<br />
COX-2 cyclooxygenase-2<br />
CSF cerebrosp<strong>in</strong>al fluid<br />
CT computarized tomography<br />
CySH cyste<strong>in</strong>e<br />
DA 3-hydroxytyram<strong>in</strong>e hydrochloride (dopam<strong>in</strong>e)<br />
DAergic dopam<strong>in</strong>ergic<br />
DAT dopam<strong>in</strong>e transporter<br />
DES dialysis encephalopathy syndrome<br />
DLB dementia with Lewy bodies<br />
DMV dorsal motor nucleus <strong>of</strong> the vagus<br />
DOPAC dihydroxyphenylacetic acid<br />
DOPAL 3,4-dihydroxyphenylacetaldehyde<br />
eNOS endothelial nitric oxide synthase<br />
EOPD early onset <strong>of</strong> Park<strong>in</strong>son’s disease<br />
ER endoplasmic reticulum<br />
FeBAD fetal basis <strong>of</strong> adult disease<br />
GABA �-am<strong>in</strong>obutyric acid<br />
GPCR G-prote<strong>in</strong> coupled receptor<br />
GPe external globus pallidus<br />
GPi <strong>in</strong>ternal globus pallidus<br />
GPx glutathione peroxidase<br />
GR glutathione reductase<br />
GSH reduced glutathione
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