Mechanisms of aluminium neurotoxicity in oxidative stress-induced ...

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Now life is not only science, I would therefore use this opportunity to thank my best friend Rosi for her patience and care during good and tough times in the Ph.D. pursuit. Always beside me. Finally, I would like to dedicate this work to my family: my grandmother Carmen and my grandfather Jesús always in my mind, my brother Jesús for his way of being, and very especially my parents María del Carmen and Alfonso for their unending love and support from ever. Thank you.
Abbreviations AA ascorbic acid AD Alzheimer’s disease ADH aldehyde dehydrogenase BBB blood-brain barrier BG basal ganglia BHT butylated hydroxytoluene BioH4 5,6,7,8-tetrahydrobiopterin BSA bovine serum albumine CaM calmodulin CAT catalase CBD corticobasal degeneration Cdk5 cyclin-dependent kinase 5 CMA chaperone mediated autophagy CNS central nervous system COMT catechol-O-methyl transferase COX-2 cyclooxygenase-2 CSF cerebrospinal fluid CT computarized tomography CySH cysteine DA 3-hydroxytyramine hydrochloride (dopamine) DAergic dopaminergic DAT dopamine transporter DES dialysis encephalopathy syndrome DLB dementia with Lewy bodies DMV dorsal motor nucleus of the vagus DOPAC dihydroxyphenylacetic acid DOPAL 3,4-dihydroxyphenylacetaldehyde eNOS endothelial nitric oxide synthase EOPD early onset of Parkinson’s disease ER endoplasmic reticulum FeBAD fetal basis of adult disease GABA �-aminobutyric acid GPCR G-protein coupled receptor GPe external globus pallidus GPi internal globus pallidus GPx glutathione peroxidase GR glutathione reductase GSH reduced glutathione
Page 1: Universidade de Santiago de Compost
Page 5: Don Ramón Soto Otero y Doña Estef
Page 9: Acknowledgements The work of this t
Page 13: Abbreviations (continuation) PCC pr
Page 16 and 17: List of figures (continuation) Chap
Page 19 and 20: TABLE OF CONTENTS INTRODUCTION ....
Page 21: CHAPTER 3 Brain oxidative stress an
Page 25 and 26: INTRODUCTION PARKINSON’S DISEASE
Page 27 and 28: INTRODUCTION PD is found in all eth
Page 29 and 30: Bradykinesia INTRODUCTION Bradykine
Page 31 and 32: INTRODUCTION predate the occurrence
Page 33 and 34: Table 1: Differential diagnostic in
Page 35 and 36: INTRODUCTION Table 3: National Inst
Page 37 and 38: Figure 4: Dopamine catabolism (Mén
Page 39 and 40: The basal ganglia INTRODUCTION The
Page 41 and 42: The death of SNpc DAergic neurons I
Page 43 and 44: INTRODUCTION the dorsomedial part o
Page 45 and 46: INTRODUCTION characterized as are l
Page 47 and 48: INTRODUCTION (Olanow et al. 2004).
Page 49 and 50: Etiology and pathogenesis of PD INT
Page 51 and 52: Ageing INTRODUCTION Ageing remains
Page 53 and 54: INTRODUCTION The finding of MPTP to
Page 55 and 56: INTRODUCTION may clarify why many n
Page 57 and 58: Misfolding and aggregation of prote
Page 59 and 60: INTRODUCTION (E3) (Figure 18A). Los
Page 61 and 62:
INTRODUCTION in connection with Par
Page 63 and 64:
INTRODUCTION Oxidative damage happe
Page 65 and 66:
DA metabolism as a source of ROS IN
Page 67 and 68:
Contribution of oxidative and nitro
Page 69 and 70:
Excitotoxicity INTRODUCTION Glutama
Page 71 and 72:
INTRODUCTION al. 1996, Cicchetti et
Page 73 and 74:
Experimental models of PD INTRODUCT
Page 75 and 76:
INTRODUCTION induce selective DAerg
Page 77 and 78:
ALUMINIUM General features INTRODUC
Page 79 and 80:
INTRODUCTION Varying amounts of alu
Page 81 and 82:
INTRODUCTION and antiperspirants co
Page 83 and 84:
INTRODUCTION approximately 3% of al
Page 85 and 86:
Excretion INTRODUCTION As insoluble
Page 87 and 88:
INTRODUCTION 3.5 mg may be increase
Page 89 and 90:
INTRODUCTION Oteiza 1999), non-iron
Page 91 and 92:
Aluminium as a cell membrane menace
Page 93 and 94:
INTRODUCTION mobilization of Ca 2+
Page 95:
Aluminium impairs neurotransmission
Page 99 and 100:
AIMS OF THE PRESENT THESIS The main
Page 101:
OBJETIVOS
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OBJETIVOS 3) Evaluar de forma preci
Page 107:
CHAPTER 1 Time-course of brain oxid
Page 110 and 111:
CHAPTER 1 INTRODUCTION 86 6-OHDA (2
Page 112 and 113:
CHAPTER 1 MATERIALS AND METHODS Che
Page 114 and 115:
CHAPTER 1 followed by centrifugatio
Page 116 and 117:
CHAPTER 1 RESULTS Effects of 6-OHDA
Page 118 and 119:
CHAPTER 1 DISCUSSION 94 As shown by
Page 120 and 121:
CHAPTER 1 strategies or to study th
Page 122 and 123:
CHAPTER 1 Fig. 2 Changes in PCC in
Page 125:
CHAPTER 2
Page 129 and 130:
ABSTRACT CHAPTER 2 In the present w
Page 131 and 132:
MATERIALS AND METHODS Chemicals CHA
Page 133 and 134:
CHAPTER 2 atomization used were 1,5
Page 135 and 136:
DISCUSSION CHAPTER 2 Aluminium ente
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Table 1. Graphite furnace programme
Page 141:
CHAPTER 3 Brain oxidative stress an
Page 144 and 145:
CHAPTER 3 INTRODUCTION 120 The huma
Page 146 and 147:
CHAPTER 3 MATERIALS AND METHODS Che
Page 148 and 149:
CHAPTER 3 1:15 for hippocampus and
Page 150 and 151:
CHAPTER 3 initially incorporated to
Page 152 and 153:
CHAPTER 3 RESULTS In vivo effects o
Page 154 and 155:
CHAPTER 3 Effects of aluminium admi
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CHAPTER 3 DISCUSSION 132 Aluminium
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CHAPTER 3 hippocampus, showed simil
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CHAPTER 3 assume that the distinct
Page 162 and 163:
CHAPTER 3 Fig. 1 Levels of TBARS (A
Page 164 and 165:
CHAPTER 3 Fig. 2 Enzyme activity of
Page 166 and 167:
CHAPTER 3 Fig. 3 Microphotographs s
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CHAPTER 3 Fig. 5 Levels of TBARS (A
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CHAPTER 3 Fig. 6 In vitro effects o
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SUMMARY
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SUMMARY values were attained at 48
Page 178 and 179:
SUMMARY neurodegeneration in the DA
Page 181 and 182:
CONCLUSIONS The results obtained in
Page 183:
13) Aluminium does affect neither M
Page 187 and 188:
RESUMEN RESUMEN Desde el punto de v
Page 189 and 190:
RESUMEN zonas cerebrales excepto en
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CONCLUSIONES
Page 194 and 195:
CONCLUSIONES Capítulo 2 4) La admi
Page 196 and 197:
CONCLUSIONES 172 En base a las conc
Page 199 and 200:
Publications as a direct result fro
Page 201:
REFERENCES
Page 204 and 205:
REFERENCES Agil A., Duran R., Barre
Page 206 and 207:
REFERENCES Baquet Z. C., Bickford P
Page 208 and 209:
REFERENCES 184 1,2,3,6-tetrahydropy
Page 210 and 211:
REFERENCES 186 compacta of the subs
Page 212 and 213:
REFERENCES Chung K. K., Dawson V. L
Page 214 and 215:
REFERENCES Davies K. J. (2001) Degr
Page 216 and 217:
REFERENCES Dhillon A. S., Tarbutton
Page 218 and 219:
REFERENCES Ekstrand M. I., Falkenbe
Page 220 and 221:
REFERENCES Fleming S. M., Delville
Page 222 and 223:
REFERENCES Ghribi O., Dewitt D. A.,
Page 224 and 225:
REFERENCES Good P. F., Olanow C. W.
Page 226 and 227:
REFERENCES Hamilton E. I., Miniski
Page 228 and 229:
REFERENCES Hirsch E. C., Brandel J.
Page 230 and 231:
REFERENCES Inden M., Kitamura Y., T
Page 232 and 233:
REFERENCES Johnson V. J. and Sharma
Page 234 and 235:
REFERENCES Kim W. G., Mohney R. P.,
Page 236 and 237:
REFERENCES Kuhn W., Winkel R., Woit
Page 238 and 239:
REFERENCES 214 K.D. and Polymeropou
Page 240 and 241:
REFERENCES Maraganore D. M., Lesnic
Page 242 and 243:
REFERENCES McCord J. M. and Fridovi
Page 244 and 245:
REFERENCES Miu A. C. and Benga O. (
Page 246 and 247:
REFERENCES Nair V. D., McNaught K.,
Page 248 and 249:
REFERENCES Onyango I. G. (2008) Mit
Page 250 and 251:
REFERENCES Perez F. A. and Palmiter
Page 252 and 253:
REFERENCES Przedborski S. and Goldm
Page 254 and 255:
REFERENCES Rifat S. L., Eastwood M.
Page 256 and 257:
REFERENCES Rymar V. V., Sasseville
Page 258 and 259:
REFERENCES Savory J., Herman M. M.
Page 260 and 261:
REFERENCES Shimizu H., Mori T., Koy
Page 262 and 263:
REFERENCES 238 the generation of hy
Page 264 and 265:
REFERENCES Taylor G. A., Moore P. B
Page 266 and 267:
REFERENCES Um J. W., Stichel-Gunkel
Page 268 and 269:
REFERENCES Vila M. and Przedborski
Page 270 and 271:
REFERENCES Whitehead M. W., Farrar
Page 272 and 273:
REFERENCES Yokel R. A. (2002a) Alum
Page 274:
REFERENCES Zhou W., Zhu M., Wilson
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