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Generalized symmetric alopecia and hyperoestrogenism associated with concurrent lymphoma, sertoli cell tumour ...1134. Kim O, Kim KS. Seminoma with hyperestrogenemiain a Yorkshire terrier. J Vet Med Sci 2005; 67 (1): 121-3.5. Morrison WB. Cancer of the reproductive tract. In:Morrison WB, ed. Cancer in dogs and cats: medical andsurgical management. 2 nd ed. Jackson: Teton NewMedia,2002: 555-64.6. Peters MAJ, de Rooij DG, Teerds KJ, van der Gaag I,van Sluijs FJ. Spermatogenesis and testicular tumours inageing dogs. J Reprod Fertil 2000; 120 (2): 443-52.7. Chun R, Garrett. Urogenital and mammary glandtumors. In: Ettinger SJ, Feldman EC, eds. Textbook of veterinaryinternal medicine. 6 th ed, St. Louis: Elsevier Saunders,2005: 784-9.8. Scott DW, Miller WH, Griffin CE. Small animaldermatology. 6 th ed. Philadelphia: W.B. Saunders, 2001:780-885.9. Feldman EC, Nelson RW. Canine and feline endocrinologyand reproduction. 3 rd ed. St. Louis: Saunders,2003: 961-76.10. Tozon N, Samardžija P, Prijič S, Fazarinc G. Caninelymphoma: cytologic study and response to therapy. SlovVet Res 2006; 43 (3): 127-33.11. Vonderhaar MA, Morrison WB. Lymphosarcoma.In: Morrison WB, ed. Cancer in dogs and cats: medical andsurgical management. 2 nd ed. Jackson: Teton NewMedia,2002: 641-70.12. Lowe AD. Alimentary lymphosarcoma in a 4-yearoldLabrador retriever. Can Vet J 2004; 45 (7): 610-2.13. Fan TM. Lymphoma updates. Vet Clin North AmSmall Anim Pract 2003; 33 (3): 455-71.14. Bush BM. Interpretation of laboratory results forsmall animal clinicians. Oxford: Blackwell Science, 1991:35-131.15. Stacy BA, Stevenson TL, Lipsitz D, Higgins RJ. Simultaneouslyoccurring oligodendroglioma and meningiomain a dog. J Vet Int Med 2003; 17 (3): 357-9.16. Alves A, Prada J, Almeida JM, et al. Primary and secondarytumours occurring simultaneously in the brain ofa dog. J Small Anim Pract 2006; 47 (10): 607-10.17. Ferguson HR. Canine mammary gland tumors. VetClin North Am Small Anim Pract. 1985; 15 (3): 501-11.18. Vail DM, MacEwen EG, Young KM. Canine lymphomaand lymphoid leukemias. In: Withrow SJ, MacEwenEG, eds. Small animal clinical oncology. 3 rd ed. Philadelphia:Saunders, 2001: 558-90.19. Gaschen FP, Teske E. Paraneoplastic syndrome. In:Ettinger SJ, Feldman EC, eds. Textbook of veterinary internalmedicine. 6 th ed, St. Louis: Elsevier Saunders, 2005:789-95.20. Dhaliwal RS, Kitchell BE, Knight BL, Schmidt BR.Treatment of aggressive testicular tumors in four dogs. JAm Anim Hosp Assoc 1999; 35 (4): 311-8.21. Coyle KA, Steinberg H. Characterization of lymphocytesin canine gastrointestinal lymphoma. Vet Pathol2004; 41 (2): 141-6.22. Leib MS, Dalton MN, King SE, Zajac AM. Endoscopcasionally(18, 24, 25). The drug hinders lymphocyteT activity and recognition of neoplastically changedcells (26), which, presumably, can consequently induceadditional concurrent neoplastic disease.Dogs with lymphoma are known to be less immunocompetentbecause of the incompetence of neoplasticlymphocytes/lymphoblasts (11, 18) or fewertotal lymphocytes, especially T cells (27). This couldhave led to the observed postoperative cystitis.Lymphoma is usually treated with combinationchemotherapy protocol (28-30), rather than corticosteroidsa single agent, however, the latter wasattempted due to the owner’s decline of the former.Corticosteroid effects are usually short-lived in caninelymphoma, and relapses are extremely common(18), and thus it is not surprising that thepresent dog was represented shortly later with signsof systemic disease, most probably a relapse of thelymphoma.ConclusionWe presented a case of multiple neoplasia in adog including B cell lymphoma, Sertoli cell tumourand seminoma. The dog had a chronic dermatopathy,probably due to hyperoestrogensim secondaryto the Sertoli cell tumour. The latter is supported byrecovery of the skin following castration. The lymphomawas probably alimentary, although a multicentriclymphoma cannot be ruled out. The cause oflymphoma is unknown, but it may have been associatedwith a previous cyclosporine therapy.AcknowledgementWe would like to thank Prof. Dr. Polona Juntesfor her contribution to the pathohistologic diagnosisand Assist. Prof. Dr. Aleksandra Domanjko Petričfor the ultrasonographic examination.References1. Heripret D. Alopecia. In: Ettinger SJ, Feldman EC,eds. Textbook of veterinary internal medicine. 6 th ed. St.Louis: Elsevier Saunders, 2005: 34-7.2. Spugnini EP, Bartolazzi A, Ruslander D. Seminomawith cutaneous metastases in a dog. J Am Anim Hosp Assoc2000; 36 (3): 253-6.3. Cooley DM, Waters DJ. Tumors of the male reproductivesystem. In: Withrow SJ, MacEwen EG, eds. Smallanimal clinical oncology. 3 rd ed. Philadelphia: Saunders,2001: 478-89.