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112 T. Plavec, N. Tozon, T. Kotnikmildly enlarged (5 cm diameter). No other abnormalitieswere observed. The biopsy of the skin was alsoperformed.Histopathology of the right inguinal mass revealedthe presence of seminoma and Sertoli celltumour in the right testis. The left testis was not examined.Lymphoma was present in the spleen andgastric lymph node. Subchronic dermatitis with amixed cell (predominantly eosinophils) populationwas present in the skin biopsies. Immunohistochemistryexamination of splenic and gastric lymphnode biopsies with CD3 and CD79 antibodies (DAKOREALTM, EnVision Detection System) confirmed aB cell lymphoma.Postoperatively a bloody-purulent urine was noticed.Dipstick and urine sediment analyses confirmeda diagnosis of purulent cystitis. Culture andsensitivity were not performed. Amoxicillin with clavulanicacid (Synulox, Pfizer) 20 mg/kg PO q12h for14 days was prescribed.The dog was rechecked one month later, seemedhealthy, gained two kilograms of body weight andits hair-coat showed signs of improvement. The palpableperipheral lymph nodes were unchanged andCBC was unremarkable (mild anaemia, haematocrit0.36 l/l). A month later, the dog had mild mandibularand praescapular lymphadenopathy. CBC was normal,with the exception of a mild anaemia (haematocrit0.34 l/l). The owners were offered a multidrugchemotherapy, but declined and were thus advisedto start corticosteroid treatment - methylprednisolone(Medrol, Pfizer; 2 mg/kg/day PO until relaps). Anadditional month later, three months after the operation,Lord’s hair looked normal again (Figure 5,6). A month later, after two months of methylprednisolonetreatment, the dog deteriorated, was depressedand anorexic and was euthanized at theowner’s request by the referring veterinarian.DiscussionThis is an unusual case with 3 different neoplasiasoccurring concurrently in a single dog. Multipletumours occurring in the brains (15, 16) or in themammary tissue (17) were reported, but authors arenot aware of any report about concurrent multipletumour occurrence in different tissues.Preoperatively seen mild nonregenerative anaemiawith the haematocrit of 0.32 l/l and thrombocytopaeniacould have developed secondarily tolymphoma (18,19), but haematocrit of 0.35 l/l wasalso seen 3 months earlier, when lymphoma was notdiagnosed yet. Such a long course of the disease isunusual for lymphoma (18).In addition to symmetrical truncal alopecia othermale patients, but not the present case, may alsopresent other signs of feminization (8). The subsequentimprovement of the skin after surgery in contrast tothe partial response to previous therapy supports theassumption that these changes were secondary tohyperoestrogenism due to Sertoli cell tumour. Plasmaoestradiol concentrations in male dogs should be lessthan 15 pg/ml. In dogs with Sertoli cell tumours, eostradiolconcentrations are usually 10 to 150 pg/ml, aswas in the present case (87,9 pg/ml) (9).Sertoli cell tumours metastasize in 2-14% ofcases; seminomas do so even less frequently. Mostcommonly they metastasize to the sublumbar(3), inguinal and iliac lymph nodes, lungs, liver,spleen, kidneys, pancreas (9), subcutis, brain andeyes (20). The above mentioned lymph nodes werenot enlarged in our case, as observed upon theexploratory laparotomy. However, gastric and mesentericlymphadenopathy was observed. Whilethe gastric lymph node presented lymphoma andhad no evidence of a testicular cancer metastasis,the mesenteric lymph nodes were not examined histologically.Although we cannot rule out that theywere enlarged due to metastasis of the testiculartumours, it is more likely that lymphoma was thecause. A postoperative serum oestrogen could haveaided in determination of Sertoli cell tumour metastasis.Retrospectively, considering the chronic diarrhoea,unresponsive to antibiotics, but responsive tocyclosporine, the mesenteric and gastric lymphadenopathy,and diagnosis of lymphoma in the latteras well as in the spleen, we believe this was a case ofalimentary lymphoma. It is presumed that they aremost likely B-cell in origin (18), but newer studiesare conflicting (21). However, it could be also a stageIVa of the multicentric form (18), which is perhapsmore likely regarding subsequent development ofgeneralised lymphadenopathy.The chronic diarrhoea, mentioned in the history,could develop due to other causes such as lymphocytic-plasmaciticenteritis (LPE) or giardiasis, asthe dog was positive for the latter. Giardiasis seemsto be a less likely cause for the diarrhoea as thedog failed to respond to a prolonged metronidazoleand spiramycin treatment, and did respond to cyclosporine(22, 23). It has been suggested, that LPEmay be a prelymphomatous change in the gastrointestinaltract (18). Cyclosporine treatment has beenreported to induce lymphoma or other tumours oc-