Professor Narinder Rawal, MD, PhD, FRCA (Hon) - AKUTNE.CZ
Professor Narinder Rawal, MD, PhD, FRCA (Hon) - AKUTNE.CZ
Professor Narinder Rawal, MD, PhD, FRCA (Hon) - AKUTNE.CZ
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1. Local and systemic chemicals drivepain signalling2. Neuroma at injury site - excitabilityin sensory fibres3. Changes in gene expression indorsal front ganglion4. Dorsal horn - central sensitization5. Descending controls modulatetransmission in spinal cord6. Limbic system and hypothalamus -altered mood, behaviour7. Sensation of pain generated incortex (past experiences, culturalinputs, expectations)8. Genomic DNA predispose (or not)patient for chronic pain