Lake Como 2|4 October 2011 - CHIMICA Oggi/Chemistry Today
Lake Como 2|4 October 2011 - CHIMICA Oggi/Chemistry Today Lake Como 2|4 October 2011 - CHIMICA Oggi/Chemistry Today
SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER ABSTRACT BIOGRAPHY Ayman D. Allian In situ FTIR monitoring for continuous chemistry Ayman D. Allian Abbott Laboratories - USA Ayman D. Allian received his PHD at the National University of Singapore under Prof. Marc V. Garland and then joined Professor Enrique Iglesia group at University of California, Berkeley as a postdoctoral. The main focus of his research was the development of in-situ IR and chemometric tools to study reaction mechanism of homogeneous and heterogeneous catalytic reactions. In 2008, Ayman joined Abbott Process Safety Lab carrying out calorimetric and thermal stability studies. He utilized the calorimetric data in combination with kinetics, PAT, chemometric, theoretical chemistry to better understand reaction mechanism and hazards prior to scale up. He is also driving the fl ow chemistry effort at Abbott Laboratories. He gave several scientifi c talks and has been an invited speaker at numerous international and national conferences. His research work has been published in the form of 11 articles in top tier international journals with some of the work featured on the front cover. He was a recipient of four awards at Abbott including the Abbott Excellence and Abbott Impact award. The successful transformation of batch processes to fl ow chemistry relies on two foundations. First, good understanding of the reaction rates of the process at hand as it dictates both the choice of the fl ow setup and fl ow rates to be used during the continuous process. Second, there is a need to detect process upsets to ensure highest degree of product quality and yield during continuous processing, which can be performed using robust online PAT tools. In this study, the use of in situ FTIR spectroscopy as a powerful tool that allowed seamless adaptation of highly energetic ozonolysis chemistry to fl ow will be demonstrated. In situ FTIR provided a wealth of information on ozone mass transfer, the required ozone-tosubstrate ratio, and other key factors that are critical for a successful continuous process. During continuous operation, the same in situ FTIR was used as PAT tool to monitor the process and eliminated the need for offl ine analysis. This understanding provided by FTIR allowed the development of a continuous ozonolysis apparatus utilized to generate 2.5 kg of product with only a two week lead time. 5 Lake Como 2|4 October 2011
SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER ABSTRACT BIOGRAPHY Franz Amann Ozonolysis in a micro reactor system Franz Amann Dishman Group - Switzerland Amann’s expertise is built on more than 12 years working within the pharmaceutical industry. The majority of them with CARBOGEN AMCIS (part of the Dishman Group) where he started as project chemist after completing his doctoral degree. Later on he was appointed as Scientifi c Specialist, where he assumed responsibilities working in synthesis of APIs under cGMP, process optimization, carbohydrate chemistry and micro reactor technology (MRT). One of the focuses of Amann’s work on MRT is Dishman Group unique device for continuous ozonolysis. Dr Amann holds a master’s degree in Chemistry from the University of Constance, Germany where he also obtained a PhD degree through his thesis on: “Synthesis and investigation of donor-analogue glycosyl transferase-inhibitors“. Dishman (Innovative Ozone Systems/Carbogen Amcis) is working with a proprietary device for continuous ozonolysis based on a micro reactor set-up. Although the reactions are run under pressure the fl ow chemistry approach delivers safety advantages due to the prevention of accumulation of ozonides. The technical set-up and several chemical examples will be discussed. In most cases, the ozonolysis itself works satisfactory but the ozonide processing in semi-batch mode had to be adapted to the requirements of the continuous device. Continuous and batch wise production gave comparable results with regard to yield and quality. 6 Lake Como 2|4 October 2011
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ABSTRACT<br />
BIOGRAPHY<br />
Ayman D. Allian<br />
In situ FTIR monitoring for continuous chemistry<br />
Ayman D. Allian<br />
Abbott Laboratories - USA<br />
Ayman D. Allian received his PHD at the National University of Singapore under Prof. Marc V.<br />
Garland and then joined Professor Enrique Iglesia group at University of California, Berkeley<br />
as a postdoctoral. The main focus of his research was the development of in-situ IR and<br />
chemometric tools to study reaction mechanism of homogeneous and heterogeneous<br />
catalytic reactions.<br />
In 2008, Ayman joined Abbott Process Safety Lab carrying out calorimetric and thermal<br />
stability studies. He utilized the calorimetric data in combination with kinetics, PAT,<br />
chemometric, theoretical chemistry to better understand reaction mechanism<br />
and hazards prior to scale up. He is also driving the fl ow chemistry effort at<br />
Abbott Laboratories.<br />
He gave several scientifi c talks and has been an invited speaker at<br />
numerous international and national conferences. His research work<br />
has been published in the form of 11 articles in top tier international<br />
journals with some of the work featured on the front cover. He was a<br />
recipient of four awards at Abbott including the Abbott Excellence and<br />
Abbott Impact award.<br />
The successful transformation of batch processes to fl ow chemistry relies on two foundations.<br />
First, good understanding of the reaction rates of the process at hand as it dictates both the choice of the fl ow setup and fl ow rates<br />
to be used during the continuous process.<br />
Second, there is a need to detect process upsets to ensure highest degree of product quality and yield during continuous<br />
processing, which can be performed using robust online PAT tools.<br />
In this study, the use of in situ FTIR spectroscopy as a powerful tool that allowed seamless adaptation of highly energetic ozonolysis<br />
chemistry to fl ow will be demonstrated. In situ FTIR provided a wealth of information on ozone mass transfer, the required ozone-tosubstrate<br />
ratio, and other key factors that are critical for a successful continuous process. During continuous operation, the same<br />
in situ FTIR was used as PAT tool to monitor the process and eliminated the need for offl ine analysis. This understanding provided by<br />
FTIR allowed the development of a continuous ozonolysis apparatus utilized to generate 2.5 kg of product with only a two week<br />
lead time.<br />
5<br />
<strong>Lake</strong> <strong>Como</strong><br />
<strong>2|4</strong> <strong>October</strong> <strong>2011</strong>
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