Lake Como 2|4 October 2011 - CHIMICA Oggi/Chemistry Today

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ABSTRACT
BIOGRAPHY
Achieving production scale fl ow chemistry
Barry Johnson
Alfa Laval - Sweden
Barry Johnson
Barry R. Johnson is Product & Process Development Manager, Alfa Laval Reactor Technology,
and works out of Alfa Laval’s Tumba site in Sweden.
Johnson joined Alfa Laval in 2002, working with the commercial investigation and development of
various technologies and products for process intensifi cation. As the Reactor Technology Product
Manager he is currently engaged in the worldwide launch and early implementation phases of
Plate Reactor technology for the company. On a daily basis he is involved in approaching and
supporting customers, developing chemical case studies for the Plate Reactor technology and
in the design, development and characterization of Plate Reactor units.
Prior to joining Alfa Laval, Johnson was at a chemical engineering consulting fi rm in
the United Kingdom, where he was fi rst introduced to the concepts of process
intensifi cation and continuous reactor technology. He also managed Mixing
research consortia during his tenure.
Johnson holds a Bachelor’s degree in Chemistry and a PhD in Physical
Chemistry - “Oscillations and Chaos in Combustion Chemistry”- both
from the University of Leeds, Leeds, England. He has completed
post doctorate studies in Analytical Science and Chemical Chaos.
Johnson has also authored educational software and books for teaching and
assessment in undergraduate Chemistry courses.
Alfa Laval is a leading global provider of specialized products and engineered
solutions, dedicated to helping its customers to optimize the performance of their
processes, time and time again. Alfa Laval helps its customers to heat, cool, separate
and transport products such as oil, water, chemicals, beverages, foodstuffs, starch and
pharmaceuticals through its worldwide organization in almost 100 countries.
Alfa Laval has embarked upon a demonstration programme for Plate Reactors at large scale in order to contribute to the case for
continuous process plants in the Fine and Pharmaceutical Industry. Reactions which utilize reagents and chemistries common in
the industry are chosen to address the issues of operating with real materials. The study is aimed primarily at developing scale up
guidelines, but will also, inevitably, give lessons on process startup and shutdown, economics and equipment (both reactor and
ancillaries) performance.
In this presentation we will present our experience from 2 reactions, a TEMPO catalysed oxidation and an organometallic synthesis
/ reduction. These reactions introduce different and common processing challenges including immiscible phases, competing
byproduct reactions, sensitive reagents and highly energetic materials.
Studies are performed at a number of different reactor sizes and throughputs culminating with operation in a ART ® Plate Reactor
PR49 at the 50 to 100 L / hr range. At each scale the reaction yield is assessed with regard to the reactor operation and performance.
Adaptions to the operating scenario and to the reactor for operation at the next larger scale are determined and implemented.
15
Lake Como
2|4 October 2011