Lake Como 2|4 October 2011 - CHIMICA Oggi/Chemistry Today

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SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER ABSTRACT BIOGRAPHY Scaling up fl ow reactors (Biotech case study) Gilda Gasparini AM Technology - UK Gilda Gasparini Gasparini graduated in Chemical Engineering at Universitá degli Studi di Bologna and took her PhD in Chemical Engineering at Loughborough University. Her research was focused on particle production by emulsifi cation techniques for controlled release drug administration. Since October 2008 she is responsible for AM Technology continuous reactors. She has been involved in the design development and she is following a number of projects including FP7 projects involving the Cofl ore ACR for APIs production and crystallization and a TSB funded project on biocatalysis. Unlike batch reactors, the output of a fl ow device can be changed without altering the hardware or set-up conditions. This fl exibility saves time and cost in development. The improved control capabilities of fl ow systems can also deliver better yield and productivity. However, the use of fl ow reactors in bio applications are still limited. Traditionally, fl ow systems have been considered unable to handle multiphase systems and long reaction time effi ciently. Three UK technology companies, C-Tech Innovation, Ingenza and AM Technology are collaborating to develop new fl ow process techniques for bio manufacturing. The project will integrate all aspects of bioprocess development from catalyst discovery and engineering, to process design, through to small footprint manufacturing of high value products. The objectives of this project is to design a compact fl ow reactor for continuous bio processing and develop improved process design techniques to accelerate the introduction of new bio-manufacturing processes for a variety of product types such as unnatural amino acids and chiral amines. Results will be shown shown based on the biocatalytic oxidase of the D-amino acid giving a mixture of L-amino acid and the a-ketoacid using wild-type D-amino acid oxidase. This is a multi-phase multi-phase reaction (G/L/S) with a reaction time in batch of over 24 hours. hours. Tests on the optimization optimization from batch to continuous at the lab scale have already shown shown a reduction in reaction time from 24 24 to 3 hours hours and the following production scale up study results results will will be shown and discussed. 13 Lake Como 2|4 October 2011
SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER ABSTRACT BIOGRAPHY Continuous fl ow reactors: right platforms for CRO/CMO Yi Jiang Corning Reactor Technologies - China Yi Jiang Yi Jiang currently is the Regional Business Director of Asia Pacifi c located in Shanghai for Corning Reactor Technologies. He was the Manager of Global Reactor Engineering and Application Engineering at Corning European Technology Center in France. Prior to joining Corning Reactor Technologies in 2008, he was a Project Manager and Research Manager for Chemical Systems & Integration at Corning Corporate Research in upstate New York. Before joining Corning in 2003, Yi worked in chemical & petrochemical industries such as Sinopec, DuPont, and ConocoPhillips where he was primarily focusing on industrial reactor designs, process development and novel reactor applications. Yi earned his PhD in chemical engineering from Washington University in St. Louis, a MS, and BS all in chemical engineering from China. Yi hold more than 10 Patents, 25 publications in top ranking chemical engineering journals. In last 5 years, Yi has been serving as chairs/co-chairs for novel reactor technical sessions at AIChE Annual Meetings, Asia Pacifi c Chemical Reactor Engineering Conferences etc. This presentation will highlight some recent technology breakthroughs in continuous fl ow reactors, and how these advancements can enhance the fl exibility in process development and the scalability in cost-effective production. Searching for better “effi ciency” and “fl exibility in Big Pharma has led to signifi cant growth in CRO/CMO business today. Globally CRO has undertaken 1/3 of drug development, with annual market expansion rate of 20-25%. Asia pacifi c becomes a crucial region crowed with a signifi cant number of CRO/CMO competing with quality, cost, and service reputation. Besides the nature of this cost-conscious business, dedicated CRO/CMO must provide fast response to customer’s need, combined with their fl exible, reliable, and competitive specialist approaches. This presentation will summarize how module-based advanced fl ow reactors have been applied for effective fl ow-chemistry process development of multipurpose, and why they could quickly meet the product demands in competitive and dynamic ecosystem. As the providers of this new technology platform, how important to help CRO/CMO recognize the potentials of this technology and delivery values of this technology applications. 14 Lake Como 2|4 October 2011
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Lake Como 2|4 October 2011 - CHIMICA Oggi/Chemistry Today

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