Lake Como 2|4 October 2011 - CHIMICA Oggi/Chemistry Today

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SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER ABSTRACT BIOGRAPHY Wenting Chen President, CEO of Beijing Laviana Pharmatech Co., Ltd. and Laviana (Taizhou) Pharmchem Co., Ltd. A synthetic organic chemist and a chemical engineer by training, turned into a medicinal chemist then an entrepreneur (Co-founded Laviana Companies). A US pharmaceutical industry veteran with over 10 years working experience as a bench chemist working at Smithkline Beecham Pharmaceutical, Dupont-Merck Pharmaceutical, Dupont Pharmaceutical and Bristol-Myers Squibb Company. Scientifi c background with tracking record of publications and patents. Leadership with proving record in leading the CRO and CMO organizations as well as organizing professional organization. Continuous fl ow reactor: a platform toward the green manufacturing Wenting Chen Beijing Laviana Pharmatech Co., Ltd. & Laviana (Taizhou) Pharmchem Co., Ltd. - China Applying continuous fl ow technology in manufacture process can improve the economic effi ciency of current process by improving the reaction yield, minimizing the solvent use, reducing the waste generated, expanding the safety margin as well as achieving energy saving and process consistency. The process developed in house using micro reactor in Laviana for ongoing CMO projects showed that the purity of crude products increased, the solvent use can be reduced or eliminated, and the overall process can be automated to eliminate the chance of error. The micro reactor technology provides a unique platform to develop applications in making chemical manufacture greener, to access an easy and quick scalable methodology in bulk chemical manufacture, and to make the in-lab manufacturing of bulk chemical possible. 9 Lake Como 2|4 October 2011
SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER SPEAKER ABSTRACT BIOGRAPHY Pietro Delogu Pietro Delogu is a chemist who spent his professional life in industrial research. He started working in the Research Centre Montedipe, the petrochemical division of Montedison, located in Bollate, near Milano. For 15 years his interests were in the fi eld of process thermodynamics and kinetics, applied to process modelling, mainly for petrochemical processes. From 1985 to 1987 he worked at the Donegani Institute of Novara, the Corporate Research Centre of Montedison, organising a new Department of Chemical and Process Technologies. In 1987 his fi eld of activity changed: he was charged at fi rst of the direction of the R&D Division of ACNA C.O., and after of the R&D Division in Caffaro. In this case the focus was on the dyes and fi ne chemical process development, with special attention to agrochemicals. Since 2004 he is the CEO of Serichim S.r.l., a Contract Research Company operating in Torviscosa. Serichim is one of the fi rst chemical research companies based in Italy, involved in pharmaceutical and chemical process development. His professional skills include process analysis and synthesis exploitation, unit operation sizing, experimental team organisation. During his activity he has published about 40 paper and patents. Pietro Delogu teaches Industrial Chemistry at the Chemical Engineering Faculty of Trieste. Continuous fl ow processes: a multiproduct modular approach Pietro Delogu Serichim S.r.l. - Italy The use of continuous processes for pharma products and intermediates is going to be more and more popular. Resistances to the introduction of this “new” approach in the industrial practice are progressively overcome, as the valuable advantages in terms of yields, product quality, safety and production costs become evident. As this technology is leaving the phase of its infancy, innovation efforts should be devoted to increase operability and to better defi ne the criteria for qualifi cation of equipments and validation of processes. Systems able to afford the continuous operation advantages, at the same time retaining the fl exibility typical of the batch plants have to be designed and offered to the pharma industry. Our communication discusses two topics: fi rst, how scaling up can be carried out in order to guarantee results independent of the reactor size for the plant reaction section (when a conventional reaction system, based on plug fl ow reactors, is used); second, a typical sequence of unit operations, able to effect the production of several APIs, is presented and proposed as a continuous multiproduct unit. The multiproduct plant approach should be considered a very interesting requisite in order to allow productions in campaigns based on continuous processes. 10 Lake Como 2|4 October 2011
Page 1 and 2: in partnership with Organised by La
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Lake Como 2|4 October 2011 - CHIMICA Oggi/Chemistry Today

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