FINAL PROGR AM - American Society of Gene & Cell Therapy

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AMERICAN SOCIETY OF GENE THERAPY • Final Program 97 ABSTRACTS SATURDAY, JUNE 4 839 Lentiviral Vectors Encoding Connexin43 Mutants Reduce Gap Junction Function: Toward Molecular Ablation of Re-Entrant Cardiac Arrhythmias Eddy Kizana, Samantha L. Ginn, Christine Smyth, Anita Boyd, Stuart P. Thomas, David G. Allen, David L. Ross, Ian E. Alexander 840 Recombinant Sendai Virus Vectors with Matrix Protein Gene Deletion Restore Dendritic Cell Allostimulatory Activity Sorin Armeanu, Irina Smirnow, Sascha Bossow, Wolfgang J. Neubert, Ulrich M. Lauer, Peter Brossart, Michael Bitzer 841 A Cytoplasmic Gene Therapy with Sendai Virus Vectors: Reduction of Cytopathic and Immunogenic Reaction of New Class Cytoplasmic RNA Vector Makoto Inoue, Hitoshi Iwasaki, Mariko Yoshizaki, Akihiro Tagawa, Kentaro Washizawa, Takashi Hironaka, Mamoru Hasegawa 842 Repeated Administration of Sendai Virus into Lung Uta Griesenbach, Gerry McLachlan, Luci Somerton, David Collie, Makoto Inoue, Takashi Hironaka, Toshiyuki Owaki, Duncan M. Geddes, Mamoru Hasegawa, Eric W. F. W. Alton 843 The Tupaia Paramyxovirus Envelope as Vector Delivery Module: Novel Fusion Protein Cleavage-Activation Sequence and Attachment Protein Retargeting Christoph Springfeld, Veronika von Messling, Christian A. Tidona, Gholamreza Darai, Roberto Cattaneo 844 Determinants of Viral Tropism: A Morbillivirus V Protein Exerts Host Defense Evasion Function in T Lymphocytes Veronika von Messling, Roberto Cattaneo 845 Properties of Sindbis Virus Vectors Produced with a Chimeric Split Helper System Anna Ketola, Sondra Schlesinger, Jarmo Wahlfors 846 In Vivo and In Vitro Cell Targeting with Library-Selected Protease-Activatable Replication-Competent Retroviruses Klaus Cichutek, Richard M. Schneider, Astrid Schwantes, Yuansheng Sun, Christian J. Buchholz, Irene Hartl, Stephen J. Russell AAV Vectors: Vector Development 847 Adeno-Associated Virus Capsids from Divergent AAV Clades and Subgroup C Adenovirus Capsids Share a Common Microtubule-Binding Mechanism Relevant to Virus Trafficking Samir A. Kelkar, Bishnu P. De, Guangping Gao, James M. Wilson, Ronald G. Crystal, Philip L. Leopold 848 Development of AAV Vectors Targeted to Vascular Endothelium Matthew Stachler, Jennette Crumine, Jeffrey Bartlett 849 Transduction of Mouse Dendritic Cells Is Enhanced by Repetitive Infection with Self-Complementary Adeno- Associated Virus 6 Combined with Immunostimulatory Ligands Wayne A. Aldrich, Changchun Ren, April F. White, Shang- Zhen Zhou, Sanjay Kumar, Connie B. Jenkins, Denise R. Shaw, Theresa V. Strong, Pierre L. Triozzi, Selvarangan Ponnazhagan 850 Efficiency of Six AAV Serotypes in Transducing Rat Myocardium In Vivo Julieta Palomeque, Jennifer A. Wellman, Shangzhen Zhou, Peter Colosi, Manuel Ramos-Kuri, Federica del Monte, Roger J. Hajjar 851 Development of Organ Homing AAV-2 Vectors Lorraine M. Work, Stuart A. Nicklin, Nicola Britton, Michael Hallek, Hildegard Buning, Andrew H. Baker 852 Human ANP32B Protein Binds AAV-2 Rep and Increases Viral Replication and rAAV Production Gianluca Pegoraro, Alessandro Marcello, Michael P. Myers, Mauro Giacca 853 Persistent Expression of Single Chain Antibodies Mediated by AAV5 and AAVrh.10 Vectors Julie L. Boyer, Jeffrey Howard, Neil R. Hackett, Robert G. Pergolizzi, James M. Wilson, Ronald G. Crystal 854 Optimization of AAV Serotype and Promoter for Increased Distribution of Expression in Both Somatic and Central Nervous Systems of Mice Haiyan Fu, Joseph Muenzer, Lu Kang, Jerillyn S. Jennings, Richard J. Samulski, Douglas M. McCarty
98 8th Annual Meeting • June 1 - 5, 2005 • St. Louis ABSTRACTS SATURDAY, JUNE 4 855 In Vivo Spinal Cord Uptake and Neuronal Binding Properties of Tet1: A Potential Means for Enhanced Spinal Cord AAV Delivery Thais Federici, James K. Liu, Qingshan Teng, Mary Garrity- Moses, Jun Yang, Nicholas M. Boulis 856 Transduction Patterns, Enzyme Distribution, and Vector and Enzyme Transport Resulting from Unilateral Injections of AAV 7, 8, 9, or Rh10 Expressing β-Glucuronidase into Select Brain Regions of the C3H Mouse Cassia N. Cearley, John H. Wolfe 857 A Versatile and Efficient Viral Vector Platform for Stable In Vivo Expression of Short Hairpin RNA Dirk Grimm, Kusum Pandey, Konrad L. Streetz, Mark A. Kay 858 Adeno-Associated Virus Vector Serotype 8 (AAV8) Achieves a Higher Level of Gene Transfer to the Central Nervous System (CNS) upon Intraventricular Injection in Neonatal Mice Compared to AAV1 and AAV2 Marike Broekman, Fabricio Costa, Comer Laryssa, LeRoy Stan, Sena Esteves Miquel 859 Enhancing Neurotropism with Multiple Mutations in the AAV-2 Capsid Jianfeng Xu, Caroline Bass, Chunyan Ma, Ernest F. Terwilliger 860 Tissue Distribution of Expression Using AAV8-Based Vectors after Intramuscular Injection and Other Routes of Delivery Tsuyoshi Ogura, Hiroaki Mizukami, YuanYuan Zhang, Takashi Okada, Akihiro Kume, Seiji Madoiwa, Jun Mimuro, Yoichi Sakata, Keiya Ozawa 861 AAV Gene Delivery for the Cornea Jia Liu, Sonal S. Tuli, David C. Bloom, Gregory S. Schultz, William W. Hauswirth, Alfred S. Lewin 862 Adipose Tissue Transduction Using AAV8-Based Vectors: Inadvertent Gene Transfer into Liver YuanYuan Zhang, Tsuyoshi Ogura, Jun Mimuro, Takashi Okada, Akihiro Kume, Yoichi Sakata, Keiya Ozawa, Hiroaki Mizukami 863 Directed Evolution of Adeno-Associated Virus (AAV) Vectors for Human Gene Therapy Luca Perabo, Jan Endell, Susan King, Daniela Goldnau, Kerstin Lux, Michael Hallek, Hildegard Buening 864 Adsorption of Adeno-Associated Virus to Commonly Used Catheter Materials Daisy P. Cross, Erica TenBroek, Cygni (Howie) Chan, Laura Christoferson, Orhan Soykan, Daniel C. Sigg 865 Focus on Specificity: Creating Efficient CML-Specific Recombinant Adeno-Associated Viral (AAV) Vectors Using a Random Peptide Library Marius Stiefelhagen, Marlon R. Veldwijk, Stephanie Laufs, Jurgen A. Kleinschmidt, Frederik Wenz, W. Jens Zeller, Stefan Fruehauf 866 Recombinant AAV 1, 2, 5, 8 and Chimeric 1/2-1/8 Serotypes Display Differential Transduction Efficiency after Delivery to Mouse Brain Fabricio F. Costa, Marike Broekman, Stanley G. LeRoy, Laryssa A. Comer, Miguel Sena-Esteves 867 Use of AAV Display Libraries to Generate Myotropic Vectors Yu-Hung Kuo, Justin Fraser, Michael G. Kaplitt 868 Effective Purification of Adeno-Associated Virus Vectors by Disposable Ion Exchange Membranes Takashi Okada, Mutsuko Nonaka-Sarukawa, Takayuki Ito, Takashi Matsushita, Hiroaki Mizukami, Akihiro Kume, Keiya Ozawa 869 Infectious Titer Assay for Recombinant Adeno-Associated Virus Vectors Using Direct Cell Lysis and Endpoint Taqman PCR Simon M. Grainger, Richard Peluso, Christopher J. Gerard 870 Transfection of Mammalian Cells Using Linear Polyethylenimine Is a Simple and Effective Means of Producing Recombinant AAV Sharon E. Reed, Elizabeth M. Staley, David J. Pintel, Gregory E. Tullis 871 rAAV2-Mediated Gene Expression in Primary Cortical Neural Cells Following Inhibition of DNA Synthesis and/or EGFR Tyrosine Kinase Young Ran Nam, Sung Jin Kim, Chul-Hyen Joo, Yoo Kyum Kim, Heuiran Lee Adenovirus Vectors: Vector Technologies 872 Chimpanzee Derived Adenoviral Vectors Transduce and Activate Human Dendritic Cells Sury Somanathan, Soumitra Roy, Guangping Gao, Arbans Sandhu, James M. Wilson
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156 NOTES 8th Annual Meeting • Ju
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FINAL PROGR AM - American Society of Gene & Cell Therapy

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