FINAL PROGR AM - American Society of Gene & Cell Therapy
FINAL PROGR AM - American Society of Gene & Cell Therapy
FINAL PROGR AM - American Society of Gene & Cell Therapy
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<strong>AM</strong>ERICAN SOCIETY OF GENE THERAPY • Final Program 95<br />
ABSTRACTS<br />
SATURDAY, JUNE 4<br />
808 11:30 <strong>AM</strong><br />
Monitoring <strong>of</strong> Transgene Expression in Cancer Patients<br />
with Positron Emission Tomography (PET)<br />
Bruno Sangro, Ivan Penuelas, Guillermo Mazzolini, Jose F.<br />
Boan, Josep M. Marti-Climent, Maria Ruiz, Cheng Qian,<br />
Nagichettiar Satyamurthy, Jorge R. Barrio, Michael E. Phelps<br />
Jose A. Richter, Sam Gambhir, Jesus Prieto<br />
809 11:45 <strong>AM</strong><br />
mda-7 Kills Pancreatic Cancer <strong>Cell</strong>s by Inhibition <strong>of</strong> Wnt/<br />
PI3K Signaling: Identification <strong>of</strong> IL-20 Receptor-<br />
Mediated Bystander Activity Against Pancreatic Cancer<br />
Sunil Chada, Dora Bocangel, Ramesh Rajagopal, Elizabeth<br />
Grimm, Abner M. Mhashilkar, Mingzhong Zheng<br />
810 12:00 PM<br />
Ex-Vivo Activation and <strong>Gene</strong>tic Manipulation <strong>of</strong> Human<br />
T <strong>Cell</strong>s Results in Consistent In-Vivo Expansion and<br />
Lethal GvHD in a Novel Murine Xenotransplant Model<br />
Bruno Nervi, Michael P. Rettig, Julie K. Ritchey, Gerhard<br />
Bauer, Jon Walker, Phillip E. Herrbrich, Todd E. Meyerrose,<br />
Mark Bonyhadi, Jan A. Nolta, John F. DiPersio<br />
Oral Abstract Session 417<br />
<strong>Gene</strong> <strong>Therapy</strong> Approaches to Pulmonary Disease<br />
Room: 261/262<br />
811 10:15 <strong>AM</strong><br />
ACE-Targeted eNOS and BMPR2 <strong>Gene</strong> <strong>Therapy</strong><br />
Attenuates Pulmonary Hypertension in a Chronic<br />
Hypoxia Rat Model<br />
Ann M. Reynolds, Mark D. Holmes, David T. Curiel, Andrew<br />
H. Baker, Paul N. Reynolds<br />
812 10:30 <strong>AM</strong><br />
Non-Human Primate Serotype rh.10 AAV Directed<br />
Therapeutic Serum Levels <strong>of</strong> að1-antitrypsin Following<br />
Intrapleural Administration in Mice with Pre-Existing<br />
Immunity to AAV<br />
Bishnu P. De, Adriana Heguy, Neil R. Hackett, John Lee,<br />
Guangping Gao, James M. Wilson, Ronald G. Crystal<br />
813 10:45 <strong>AM</strong><br />
Distribution <strong>of</strong> Transgene Expressing <strong>Cell</strong>s Following<br />
Intramarrow Injection to Transduce Hematopoietic Stem<br />
<strong>Cell</strong>s In Situ Using rSV40 Vectors<br />
Jean-Pierre Louboutin, Bianling Liu, David S. Strayer<br />
814 11:00 <strong>AM</strong><br />
Adenovirus-Mediated <strong>Gene</strong> Transfer Demonstrates That<br />
Pirin, a Transcription Factor Up-Regulated in the<br />
Bronchial Epithelium by Cigarette Smoke, Mediates<br />
Bronchial Epithelial <strong>Cell</strong> Apoptosis<br />
Brian D. Gelbman, Adriana Heguy, Timothy P. O’Connor,<br />
Joseph Zabner, Ronald G. Crystal<br />
815 11:15 <strong>AM</strong><br />
Aerosol Delivery <strong>of</strong> Helper-Dependent Adenoviral<br />
Vector into Nonhuman Primate Lungs Results in High<br />
Efficiency Pulmonary Transduction with Minimal<br />
Toxicity<br />
Peter Hiatt, Nicola Brunetti-Pierri, David Koehler, Ruth<br />
McConnell, Julie Katkin, Donna Palmer, David Dimmock, Jim<br />
Hu, Milton Finegold, Arthur Beaudet Dee Carey, Karen Rice,<br />
Philip Ng<br />
816 11:30 <strong>AM</strong><br />
RNAi Applications for Respiratory Epithelia: Delivery<br />
and Efficacy<br />
Anthony J. Fischer, Christine L. Wohlford-Lenane, Patrick L.<br />
Sinn, Hong Peng Jia, Steven M. Varga, Beverly L. Davidson,<br />
Paul B. McCray<br />
817 11:45 <strong>AM</strong><br />
Protein Transduction Domain Mediated DFRD Correction<br />
<strong>of</strong> CFTR Function in Airway <strong>Cell</strong>s from DF508<br />
Homozygous CF Patients<br />
Zhibao Mi, Fei Sun, Xiaoli Lu, Steve Condliffe, Xiaoyan<br />
Gong, Joseph Pilewski, Raymond A. Frizzell, Paul D. Robbins<br />
818 12:00 PM<br />
Recombinant AAV1-Mediated Treatment <strong>of</strong> CNS<br />
Glycogen Accumulation in Mouse Model <strong>of</strong> Glycogen<br />
Storage Disease Type II<br />
Lara R. DeRuisseau, Cathryn S. Mah, Thomas J. Fraites, Jr.,<br />
David D. Fuller, Barry J. Byrne<br />
Presidential Symposium 430<br />
Room: America’s Ballroom<br />
819 3:20 PM<br />
Molecular Follow-Up <strong>of</strong> Patients Treated with Allogeneic<br />
Hematopoietic Stem <strong>Cell</strong> Transplantation and Donor<br />
Lymphocytes Transduced with a Retroviral Vector<br />
Expressing HSV-TK and ∆LNGFR<br />
Alessandra Recchia, Zulma Magnani, Fabrizia Urbinati,<br />
Daniela Sartori, Sara Muraro, Maria T. Lupo Stanghellini,<br />
Massimo Bernardi, Alessandra Pescarollo, Marco Bregni, Chiara<br />
Bonini Claudio Bordignon, Fabio Ciceri, Fulvio Mavilio<br />
820 3:38 PM<br />
Highly Efficient Exon-Skipping and Sustained Correction<br />
<strong>of</strong> Muscular Dystrophy Using an Adeno-Associated<br />
Viral Vector<br />
Aurelie Goyenvalle, Adeline Vulin, Jean Claude Kaplan, France<br />
Leturcq, Olivier Danos, Luis Garcia<br />
821 3:56 PM<br />
Development <strong>of</strong> a Site-Specific Integrating <strong>Gene</strong>-Deleted<br />
Adenoviral Vector for Sustained Transgene Expression<br />
Levels In Vivo<br />
Anja Ehrhardt, Stephen R. Yant, Giering A. Jeff, Hui Xu,<br />
Michele P. Calos, Mark A. Kay
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