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FINAL PROGR AM - American Society of Gene & Cell Therapy

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90<br />

8th Annual Meeting • June 1 - 5, 2005 • St. Louis<br />

ABSTRACTS<br />

FRIDAY, JUNE 3<br />

734<br />

Association <strong>of</strong> DNA Polymerase mð with Recombinant<br />

Adeno-Associated Viral Vectors<br />

David C. Brooks, Fayaz R. Khazi, Katherine A. High<br />

735<br />

Femtosecond Laser- A New Intradermal DNA Delivery<br />

Method for <strong>Gene</strong> Expression and Vaccination<br />

Evelyne Zeira, Alexandra Manevitch, Zakharia Manevitch,<br />

Menahem Harati, Hagit Yotvat, Michal Gropp, Orit Papo, Nili<br />

Daudi, Eli Kedar, Aaron Lewis Eithan Galun<br />

736<br />

Novel In Vitro and In Vivo Transcriptome Analysis<br />

Identifies New Adenovirus Responsive, Innate <strong>Gene</strong><br />

Networks<br />

Zachary Hartman, Anne Kiang, Ruth Everett, Joe Nevins,<br />

Esther Black, Andy Amalfiatano<br />

737<br />

Induction <strong>of</strong> Molecular Chimerism in Rhesus Macaques<br />

Reconstituted with Autologous CD34+ <strong>Cell</strong>s Transduced<br />

with the <strong>Gene</strong> Encoding the að(1-<br />

3)galactosyltranferase (aðGT)<br />

Lorenzo Benatuil, Robert Donahue, Aylin Bonifacino, Cynthia<br />

Dunbar, John Iacomini<br />

738<br />

Influence <strong>of</strong> the Major Histocompatibility Complex on<br />

Immunological Rejection <strong>of</strong> Skin Grafts Expressing a<br />

<strong>Gene</strong> <strong>Therapy</strong> Reporter <strong>Gene</strong><br />

Julian D. Down, Christian LeGuern<br />

739<br />

Impact <strong>of</strong> Activation, Transduction/Selection Steps on the<br />

<strong>Gene</strong> Expression Pr<strong>of</strong>ile <strong>of</strong> Ex-Vivo Retrovirally Transduced<br />

CD8+ T <strong>Cell</strong>s, Using High Density DNA<br />

Microarrays<br />

Marina Deschamps, Jean Marie Certoux, John de Vos, Nicolas<br />

Montcuquet, Thierry Reme, Mark Bonyhadi, Eric Robinet,<br />

Pierre Tiberghien, Christophe Ferrand<br />

740<br />

In Vitro Correction <strong>of</strong> 47 bp Deletion in Casp-3 <strong>Gene</strong> in<br />

Human MCF7 <strong>Cell</strong>s Using Histone-Mediated Delivery<br />

<strong>of</strong> Wild Type <strong>Gene</strong> Fragment Covering the Deletion<br />

Region<br />

Leonid A. Yakubov, Robert J. Levy<br />

741<br />

AAV Delivered Ribozymes to Recapitulate the Early<br />

Stages <strong>of</strong> Age Related Macular Degeneration<br />

Verline Justilien, Jijing Pang, William W. Hauswirth, Alfred S.<br />

Lewin<br />

742<br />

Human Artificial Chromosome (HAC) Vector Provides<br />

Long-Term Therapeutic Transgene Expression in Normal<br />

Human Primary Fibroblasts<br />

Minoru Kakeda, Masaharu Hiratsuka, Keiko Nagata, Akiko<br />

Sano, Kanako Osawa, Motonobu Katoh, Mitsuo Oshimura,<br />

Kazuma Tomizuka<br />

743<br />

Lentiviral Vector <strong>Gene</strong> Transfer in Monkeys: In Vivo<br />

Detection <strong>of</strong> <strong>Gene</strong> Expression Longitudinally Using<br />

MicroPET and Optical Imaging<br />

Alice F. Tarantal, Chang I. Lee, Daniel F. Jimenez, Sanjiv S.<br />

Gambhir, Donald B. Kohn, John J. Rossi, Simon R. Cherry<br />

744<br />

Enhanced Expression <strong>of</strong> Adenovirus Transgenes in the<br />

Mouse Liver and Human Tumors Following<br />

Topoisomerase I Inhibition<br />

Gideon Zamir, Evelyne Zeira, Eithan Galun<br />

745<br />

CD4-T <strong>Cell</strong> Responses Mediated by IFNgð and Perforin<br />

Eliminate Adenoviral-Mediated Transgene Expression<br />

from the CNS <strong>of</strong> Mice by Cytolytic and Non-Cytolytic<br />

Mechanisms<br />

Jeffrey M. Zirger, Carlos Barcia, Chunyan Liu, Maria Castro,<br />

Pedro Lowenstein<br />

746<br />

Evaluation <strong>of</strong> Nuclear Transfer and Transcription <strong>of</strong><br />

Plasmid DNA Condensed with Protamine<br />

Tomoya Masuda, Hidetaka Akita, Hideyoshi Harashima<br />

747<br />

Identification and Characterization <strong>of</strong> Mutations within<br />

the Coxsackievirus and Adenovirus Receptor (CAR)<br />

Katherine J. D. A. Exc<strong>of</strong>fon, Matthew Avenarius, Richard<br />

Smith, Joseph Zabner<br />

748<br />

Quantitative Comparison <strong>of</strong> the Intracellular Trafficking<br />

and Expression Pattern <strong>of</strong> the Exogenous <strong>Gene</strong>s between<br />

the Adenovirus and Artificial Vector<br />

Susumu Hama, Hidetaka Akita, Rie Ito, Hiroyuki Mizuguchi,<br />

Takao Hayakawa, Hideyoshi Harashima<br />

749<br />

Characterization <strong>of</strong> Adenovirus-Mediated <strong>Gene</strong> Expression<br />

in Normal, Wounded and Wound Impaired Skin<br />

Danling Gu, David Looper, David W. Kang, Diane McAllister,<br />

Erlinda Quijano, Shu Fen Wen, Monica L. Zepeda<br />

750<br />

Expression Levels <strong>of</strong> the Amphotropic Receptor May<br />

Explain Gestational Age-Dependence <strong>of</strong> Tissue Transduction<br />

in Fetal Sheep<br />

Ferhat Ozturk, Paul Park, Joe Tellez, Wayne B. Anderson,<br />

Maribeth Eiden, Esmail D. Zanjani, Graca Almeida-Porada,<br />

Christopher D. Porada

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