FINAL PROGR AM - American Society of Gene & Cell Therapy
FINAL PROGR AM - American Society of Gene & Cell Therapy
FINAL PROGR AM - American Society of Gene & Cell Therapy
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<strong>AM</strong>ERICAN SOCIETY OF GENE THERAPY • Final Program 75<br />
ABSTRACTS<br />
FRIDAY, JUNE 3<br />
477<br />
Development <strong>of</strong> SIV Based Vectors with Efficient<br />
Delivery for Vector Dynamic Studies in the Simian<br />
System<br />
Christopher Chen, Jiamo Lu, Tatiana Slepushkina, Andrew<br />
Worden, Vladimir Slepushkin, Laurent M. Humeau,<br />
Gwendolyn K. Binder, Xiaobin Lu<br />
478<br />
A HIV-1 Based Cross-Packaging System for FIV Vectors<br />
Adam S. Cockrell, Hong Ma, Thomas McCown, Kim D.<br />
Kluckman, Randy J. Thresher, Tal Kafri<br />
479<br />
Targeted Entry <strong>of</strong> Retroviral Vectors Depends on Characteristics<br />
<strong>of</strong> the Target Receptor and the Chimeric Envelope<br />
Protein<br />
Lorraine M. Albritton, Fang Li, Pankaj Kumar, Langzhu Tan<br />
480<br />
Examination <strong>of</strong> the Relationship between the Level <strong>of</strong><br />
<strong>Gene</strong> Transfer and the Number <strong>of</strong> Envelope Proteins<br />
That Are Incorporated Per Retrovirus Particle When<br />
High Doses <strong>of</strong> Purified Virus Stocks Are Used to<br />
Transduce <strong>Cell</strong>s<br />
Natalia Landázuri, Joseph M. Le Doux<br />
481<br />
Dynamics <strong>of</strong> Transduction <strong>of</strong> Human <strong>Cell</strong>s by EIAV<br />
Vectors – The Importance <strong>of</strong> <strong>Cell</strong> Entry<br />
Daniel C. Farley, Fraser J. Wilkes, James E. Miskin, Susan M.<br />
Kingsman, Kyriacos A. Mitrophanous<br />
482<br />
Neuronal <strong>Gene</strong> Transfer with HIV-1-Based Lentiviral<br />
Vectors Pseudotyped with Lyssavirus Glycoproteins<br />
Qingshan Teng, Mary E Garrity-Moses, Thais Federici, Jun<br />
Yang, Robert Kutner, Noel Tordo, Jakob Reiser, Nicholas M.<br />
Boulis<br />
483<br />
Targeted Receptor Trafficking Affects the Efficiency <strong>of</strong><br />
Retrovirus Transduction<br />
Delfi Krishna, Julia Raykin, Joseph Le Doux<br />
484<br />
Ultrasound-Mediated Microbubble Destruction and<br />
Retroviral <strong>Gene</strong> Delivery<br />
Sarah L. Taylor, Ahad Rahim, Nigel Bush, Jeff Bamber, Colin<br />
Porter<br />
485<br />
Lentivirus-Mediated <strong>Gene</strong> Transfer to Cultured Fetal<br />
Sheep Airway Epithelium and Lung Tissue Explants<br />
Ze-Yan Yu, Karen McKay, Peter Van Asperen, Maolin Zheng,<br />
Jane Fleming, Samantha Ginn, Eugenie Lumbers, Peter Rowe,<br />
Ian Alexander<br />
486<br />
Optimized Conditions for Retroviral <strong>Gene</strong> Transfer by<br />
RetroNectin ® Bound Virus Infection Method<br />
Hideto Chono, Hiromi Okuyama, Yasushi Katayama, Nobuto<br />
Koyama, Junichi Mineno, Kiyozo Asada, Ikunoshin Kato<br />
487<br />
Enhancement <strong>of</strong> Adeno- and Lentivirus Mediated <strong>Gene</strong><br />
Transfer in Human Tumor <strong>Cell</strong> Lines by <strong>Cell</strong> Permeable<br />
Peptides and Polycations<br />
Saara Lehmusvaara, Outi Meriläinen, Tanja Hakkarainen,<br />
Jarmo Wahlfors<br />
488<br />
Engineering Enhanced Retroviral Vectors through the<br />
Insertion <strong>of</strong> a His Tag into VSV-G<br />
6<br />
Julie H. Yu, David V. Schaffer<br />
489<br />
Further Studies <strong>of</strong> the Most Efficient Vector Systems for<br />
<strong>Gene</strong> Transduction into Human Dendritic <strong>Cell</strong>s Line<br />
(im-NMD)<br />
Eigo Sato, Masanari Kato, Yuko Hara, Hua Yan, Tohko<br />
Miyagi, Xiao-Kang Li, Wataru Sugiura, Naoki Yamamoto,<br />
Kenichi Teramoto, Shigeki Arii Hiromitsu Kimura<br />
490<br />
Lentiviral-Mediated <strong>Gene</strong> Transfer to <strong>Cell</strong>s <strong>of</strong> the<br />
Vasculature<br />
Ciara A. O’Shea, Robert J. Nelson, Padraig Strappe, Timothy<br />
O’Brien<br />
491<br />
Development <strong>of</strong> Fast and Efficient Methods for the<br />
Purification and Concentration <strong>of</strong> Lentiviral Vectors<br />
Rachel M. Koldej, Donald S. Anson<br />
492<br />
Harvest Timing and Media Composition Effects on<br />
Lentiviral Vector Production<br />
Christopher Ballas, Terry Johnson, Kenneth Cornetta<br />
493<br />
Concentration and Purification <strong>of</strong> Lentivirus Pseudotypes<br />
Bearing Alternative Envelope Glycoproteins<br />
Robert H. Kutner, Jakob Reiser<br />
494<br />
Assessing Lentiviral Vector Quality Using Transmission<br />
Electron Microscopy<br />
Lakshmi Sastry, Carole Miller, Terry Johnson, Aparna Jasti,<br />
Vince Gattone, Kenneth Cornetta<br />
495<br />
Upscaling <strong>of</strong> Retroviral Vector Production under GMP<br />
Guidelines to <strong>Gene</strong>rate High Titer Preparations for<br />
Clinical Use<br />
Sandra Jung, Peter Leyendecker, Frank Kogelberg, Christian<br />
Wolf, Andrea Schilz, Klaus Kuehlcke, Sonja Naundorf
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