FINAL PROGR AM - American Society of Gene & Cell Therapy
FINAL PROGR AM - American Society of Gene & Cell Therapy
FINAL PROGR AM - American Society of Gene & Cell Therapy
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72<br />
8th Annual Meeting • June 1 - 5, 2005 • St. Louis<br />
ABSTRACTS<br />
FRIDAY, JUNE 3<br />
433 3:45 PM<br />
<strong>Gene</strong> <strong>Therapy</strong> <strong>of</strong> Epilepsy by Adenovirus-Mediated<br />
Tetanus Toxin Light Chain <strong>Gene</strong> Transfer<br />
Jun Yang, Qingshan Teng, Mary E. Garrity-Moses, Thais<br />
Federici, Imad Najm, Stephan Chabardes, Michael M<strong>of</strong>fitt,<br />
Nicholas M. Boulis<br />
434 4:00 PM<br />
Long-Term Effects on Retinal Function and Structure<br />
Using AAV-Mediated <strong>Gene</strong> <strong>Therapy</strong> in Blind RPE65<br />
Null Mutation Dogs<br />
Kristina Narfstrom, Greg Tullis, Ragnheidur Bragadottir,<br />
Mathias Seeliger, Elizabeth P. Rakoczy, Martin L. Katz<br />
435 4:15 PM<br />
Functional and Morphological Rescue <strong>of</strong> the Type I<br />
Ocular Albinism Murine Retina Following AAV-Mediated<br />
<strong>Gene</strong> Transfer.<br />
Enrico M. Surace, Luciano Domenici, Katia Cortese, Consuelo<br />
Venturi, Gabriella Cotugno, Umberto Di Vicino, Alessandro<br />
<strong>Cell</strong>erino, Valeria Marigo, Carlo Tacchetti, Andrea Ballabio<br />
Alberto Auricchio<br />
Oral Abstract Session 335<br />
Infectious Diseases and Vaccines: RNAi in <strong>Gene</strong><br />
<strong>Therapy</strong> for Infections<br />
Room: 230/231<br />
436 2:00 PM<br />
shRNAs Target HIV-1 Vif <strong>Gene</strong> Coding for SOCS-Box<br />
Motif Prevent Virus Escape from RNA Interference-<br />
Mediated Inhibition<br />
Jianfei Ji, John J. Rossi<br />
437 2:15 PM<br />
Alternative Strategies To Deliver Multiple shRNAs in<br />
Order to Simultaneously Inhibit Multiple Targets<br />
Peter W. Roelvink, Michael W. Graham, David A. Suhy, Linda<br />
B. Couto, Sara M. Cunningham, Mark A. Kay, John J. Rossi,<br />
Alexander A. Kolykhalov<br />
438 2:30 PM<br />
Development <strong>of</strong> an siRNA Based <strong>Therapy</strong> for Hepatitis<br />
Virus Infection<br />
David V. Morrissey, Karin Blanchard, Lucinda Shaw, Kristi<br />
Jensen, Wendy Breen, Shawn Zinnen, Brent Dickinson, James<br />
A. McSwiggen, Chandra Vargeese, Keith Bowman Chris S.<br />
Shaffer, Lloyd Jeffs, Adam Judge, Barry Polisky, Jennifer A.<br />
Lockridge, Amy C. H. Lee, Ian MacLachlan<br />
439 2:45 PM<br />
CXCR4 and CCR5 shRNA Transgenic Macrophages Are<br />
Functionally Normal and Resist HIV-1 Infection<br />
Joseph Anderson, Ramesh Akkina<br />
440 3:00 PM<br />
A Non-Human Primate Model for Lentivirus-Mediated<br />
Anti-HIV RNAi Strategies<br />
Karen Beagles, Grant Trobridge, Brian Beard, John Rossi, Jiing-<br />
Kuan Yee, Shiu-Lok Hu, Hans-Peter Kiem<br />
441 3:15 PM<br />
Short Hairpin RNA Interference Expressed from a <strong>Gene</strong>-<br />
Deleted Adenoviral Vector Results in Reduction <strong>of</strong><br />
Hepatits B Surface Antigen Levels In Vitro and in a Small<br />
Animal Model for Hepatitis B Infection<br />
Anja Ehrhardt, Hui Xu, Felix H. Salazar, Patricia L. Marion,<br />
Mark A. Kay<br />
442 3:30 PM<br />
Evaluation <strong>of</strong> siRNA for Induction <strong>of</strong> In Vitro Resistance<br />
in HIV-1<br />
Priscilla Yam, Jerry Wu, Ying Yu, John A. Zaia, Jiing-Kuan Yee<br />
443 3:45 PM<br />
Tissue Specific Expression <strong>of</strong> Short Hairpin RNAs for the<br />
Treatment <strong>of</strong> HCV Using Liver Specific RNA Pol II<br />
Expression Cassettes<br />
David A. Suhy, Alexander A. Kolykhalov, Linda B. Couto,<br />
Luz Maria Garcia, A. Rosanna Schroeder, Amy E. Parker,<br />
Gabriel Haniff, Sara M. Cunningham, Mark A. Kay, Peter W.<br />
Roelvink<br />
Oral Abstract Session 336<br />
Targeting <strong>of</strong> Adeno Viral Vectors and Cancer Treatment<br />
Room: 123/127<br />
444 2:00 PM<br />
A New Vector Which Targets Breast Cancer and Its<br />
Vasculature<br />
Yanzheng Liu, Tao Ye, Jonathan Maynard, Hakan Akbulut,<br />
Albert Deisseroth<br />
445 2:15 PM<br />
Combinatorial Antiangiogenic <strong>Gene</strong> <strong>Therapy</strong> by<br />
Nonviral <strong>Gene</strong> Transfer Using the Sleeping Beauty<br />
Transposon Causes Tumor Regression and Improves<br />
Survival in Mice Bearing Intracranial Human Glioblastoma<br />
John R. Ohlfest, Zachary L. Demorest, Yasuhiko Motooka,<br />
Isabelita Vengco, Seunguk Oh, Eleanor Chen, Frank A.<br />
Scappaticci, Stephen C. Ekker, Walter C. Low, Andrew B.<br />
Freese David A. Largaespada<br />
446 2:30 PM<br />
Tie2 Expression Defines an Integrated System <strong>of</strong> <strong>Cell</strong><br />
Types Specifically Involved in Angiogenesis, and Provides<br />
a Platform for Targeted <strong>Gene</strong> Delivery to Tumors<br />
Michele De Palma, Mary Anna Venneri, Rossella Galli,<br />
Nathalie Belmonte, Maurilio Sampaolesi, Lucia Sergi Sergi,<br />
Luigi Naldini