FINAL PROGR AM - American Society of Gene & Cell Therapy
FINAL PROGR AM - American Society of Gene & Cell Therapy
FINAL PROGR AM - American Society of Gene & Cell Therapy
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<strong>AM</strong>ERICAN SOCIETY OF GENE THERAPY • Final Program 69<br />
ABSTRACTS<br />
FRIDAY, JUNE 3<br />
Oral Abstract Session 330<br />
RNA Virus Vectors: Integration and Vector Safety<br />
Room: Ferrara Theater<br />
386 2:00 PM<br />
Large Scale Analysis <strong>of</strong> Foamy Virus Vector Integration<br />
Sites in Human CD34+ <strong>Cell</strong>s<br />
Grant Trobridge, Daniel G. Miller, Michael A. Jacobs, James M.<br />
Allen, Erik Olson, Hans-Peter Kiem, Rajinder Kaul, David W.<br />
Russell<br />
387 2:15 PM<br />
Myeloid Sarcoma Associated with <strong>Gene</strong> Marking <strong>of</strong><br />
Hematopoietic Stem <strong>Cell</strong>s in a Rhesus Macaque<br />
Ruth Seggewiss, Stefania Pittaluga, Rima Adler, Cole Ferguson,<br />
Elio F. Vanin, Patrick F. Kelly, Robert E. Donahue, Brian P.<br />
Sorrentino, Arthur W. Nienhuis, Cynthia E. Dunbar<br />
388 2:30 PM<br />
Use <strong>of</strong> the cHS4 Chromatin Insulator to Reduce<br />
Oncoretrovirus Vector-Mediated Genotoxicity<br />
David W. Emery, Changlong Li, George Stamatoyannopoulos<br />
389 2:45 PM<br />
Testing the Oncogenic Potential <strong>of</strong> Retroviral and<br />
Lentiviral Vector Integration<br />
Eugenio Montini, Daniela Cesana, Francesca Sanvito, Sergi<br />
Sergi Lucia, Benedicenti Fabrizio, Ponzoni Maurilio, Claudio<br />
Doglioni, Luigi Naldini<br />
390 3:00 PM<br />
Flanking a Retrovirus Vector with the cHS4 Chromatin<br />
Insulator Reduces the Frequency <strong>of</strong> Vector-Mediated<br />
Trans-Activation <strong>of</strong> Endogenous <strong>Gene</strong>s<br />
Changlong Li, David W. Emery<br />
391 3:15 PM<br />
Effective <strong>Gene</strong> <strong>Therapy</strong> with Non-Integrating Lentivirus<br />
Vectors<br />
Rafael J. Yáñez-Muñoz, Kamaljit S. Balaggan, Angus<br />
MacNeil, Alexander J. Smith, Prateek Buch, Steven Howe,<br />
Yanaí Durán, Robert E. MacLaren, Patrick N. Anderson,<br />
Christine Kinnon Robin R. Ali, Adrian J. Thrasher<br />
392 3:30 PM<br />
Development <strong>of</strong> a New Lentiviral Vector for Site-Specific<br />
Integration into Mammalian Genomes<br />
Angelo Lombardo, Michelle Calos, Luigi Naldini<br />
393 3:45 PM<br />
Site-Directed Integration in Human Genome by<br />
Lentiviral Vectors Containing HIV-1 Integrase/Polydactyl<br />
Zinc Finger Fusion Proteins<br />
Wenjie Tan, Zheng Dong, Vivian Luo, Samson A. Chow<br />
394 4:00 PM<br />
Oncogenesis Following Delivery <strong>of</strong> a Non-Primate<br />
Lentiviral <strong>Gene</strong> <strong>Therapy</strong> Vector to Fetal Mice<br />
Michael Themis, Simon N. Waddington, Manfred Schmidt,<br />
Christ<strong>of</strong> von Kalle, Yoahe Wang, Faisal Al-Allaf, Lisa Gregory,<br />
Megha Nivsarkar, Matthew Themis, Maxine Holder Suzanne<br />
M. K. Buckley, Niraja Dighe, Alaine Ruthe, Ajay Mistry, Brian<br />
Bigger, Adrian J. Thrasher, Charles Coutelle<br />
395 4:15 PM<br />
Safety <strong>of</strong> In Utero <strong>Gene</strong> Delivery <strong>of</strong> Lentiviral Vectors<br />
Susan M. Kingsman, James E. Miskin, Pippa A. Radcliffe,<br />
Caroline V. Hacker, Daniel Chipchase, Nicholas D. Mazarakis,<br />
Kyriacos A. Mitrophanous<br />
Oral Abstract Session 331<br />
AAV Vectors: Vector Development<br />
Room: 240 Complex<br />
396 2:00 PM<br />
Identification and Characterization <strong>of</strong> Novel AAV Isolates<br />
Michael K. Schmidt, Emmanuelle Grott, Charles Buck, John A.<br />
Chiorini<br />
397 2:15 PM<br />
AAV-Mediated <strong>Gene</strong> Transfer to Endothelial <strong>Cell</strong>s<br />
Mo-Ying Hsieh, Yi-Lin Liu, Alexander Schlachterman,<br />
Katherine A. High<br />
398 2:30 PM<br />
Adeno-Associated Virus Serotype 8 Efficiently Crosses<br />
Blood Vessel Barrier in Muscle and Heart for Whole-<br />
Body <strong>Gene</strong> Delivery<br />
Zhong Wang, Tong Zhu, Chunping Qiao, Liqiao Zhou, Bing<br />
Wang, Jian Zhang, Chunlian Chen, Juan Li, Xiao Xiao<br />
399 2:45 PM<br />
rAAV2 Movement Through the Late and Recycling<br />
Endosomes Is Influenced by Titer <strong>of</strong> Infection<br />
Liang Zhang, Wei Ding, John F. Engelhardt<br />
400 3:00 PM<br />
Successful Production <strong>of</strong> Pseudotyped Mosaic rAAV<br />
Vectors Using a Modified Baculovirus Expression System<br />
Erik Kohlbrenner, George Aslanidi, Kevin Nash, Stanislav<br />
Shklayev, Martha Campbell-Thompson, Barry J. Byrne,<br />
Richard O. Snyder, Nicholas Muzyczka, Kenneth H.<br />
Warrington, Sergei Zolotukhin<br />
401 3:15 PM<br />
Evaluation <strong>of</strong> Primitive Murine Hematopoietic Stem and<br />
Progenitor <strong>Cell</strong> Transduction In Vitro and In Vivo by<br />
Recombinant Adeno-Associated Virus Vectors Based on<br />
Serotypes 1 through 5<br />
Li Zhong, Weiming Li, Yanjun Li, Keyun Qing, Mervin C.<br />
Yoder, Arun Srivastava
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