FINAL PROGR AM - American Society of Gene & Cell Therapy

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AMERICAN SOCIETY OF GENE THERAPY • Final Program 67 ABSTRACTS THURSDAY, JUNE 2 351 Repeat Administration of Polyethylenimine (PEI) Aerosols of Plasmid DNA to the Murine Lung Is Associated with a Loss of Gene Transfer Efficiency Lee A. Davies, Stephen C. Hyde, Deborah R. Gill 352 Gene Transfer of Angiogenic Inhibitors Suppresses Lung Tumor Growth in Spontaneous Pulmonary Metastasis Mouse Model Kexia Cai, Mai Har Sham, Weidong Xiao, Paul Tam, Ruian Xu 353 Retrovirally-Marked Human Bone Marrow Derived Mesenchymal Stem Cells Attenuate Radiation Induced Pneumonitis in a Xenotransplant Model Andrew Hope, Todd E. Meyerrose, Jan A. Nolta 354 Correction of Respiratory Function by Recombinant AAV1 Mediated Gene Therapy in a Murine Model of Glycogen Storage Disease Type II Cathryn Mah, Kerry O. Cresawn, Lara R. DeRuisseau, David Fuller, Barry J. Byrne 355 Towards Cystic Fibrosis and Airway Gene Therapy: Evaluation of EGFP Gene Expression in Murine Nasal Airways Mediated by Simian Immunodeficiency Virus Vectors Pseudotyped with Sendai Virus Glycoproteins F and HN Katsuyuki Mitomo, Makoto Inoue, Yasuji Ueda, Mie Ikegami, Uta Griesenbach, Eric W. F. W. Alton, Mamoru Hasegawa 356 Sonoporation Increases Non-Viral Gene Transfer to the Murine Lung Stefania Xenariou, Haidong Liang, Uta Griesenbach, Ray Farley, Luci Somerton, Charanjit Singh, Po-Wah So, Amy Herlihy, Stefano Ferrari, Duncan Geddes Martin Blomley, Eric Alton 357 IL-17 Induces Migration of Adult Marrow Stromal Cells to Lung Epithelium Roberto Loi, Jennifer Jaskolka, Robert Prenovitz, Ying Jian You, Steven Brody, Daniel J. Weiss 358 Gene Transfer to the Airway Epithelium Mediated by a Third Generation HIV-1 Based Vector: Efficiency and Role of Heparan Sulfate Elena Copreni, Stefano Castellani, Lucia Palmieri, Salvatore Carrabino, Luigi Naldini, Massimo Conese 359 Specific Modulation of Tight Junctions to Enhance Airway Gene Transfer Ruth S. Everett, Miriam K. Vanhook, Larry G. Johnson 360 Disturbance of Airway Epithelium Is Reduced, Whilst Lentivirus-Mediated Gene Transfer Is Maintained, after Low Dose Lysophosphatidylcholine Pre-Treatment In Vivo Patricia Cmielewski, Alice G. Stocker, David W. Parsons, Donald S. Anson 361 Radiation-Induced Lung Apoptosis Is Mediated by TNFalpha Action Ming Zhang, Jun Qian, Ming Chen, Spring Kong, Theodore S. Lawrence 362 Using Real-Time (TaqMan ® ) PCR to Genotype Offspring of Transgenic CF-null Mice – A Core Facility of the UK Cystic Fibrosis Gene Therapy Consortium Rebecca L. Smith, Lee A. Davies, Hazel Painter, Anusha Varathalingam, Deborah R. Gill, Stephen C. Hyde 363 Gene Delivery to Human Sweat Glands: A Model for Cystic Fibrosis Gene Therapy Haeyul Lee, David R. Koehler, Cho Y. Pang, Ronald H. Levine, Philip Ng, Donna J. Palmer, Paul M. Quinton, Jim Hu 364 Prevention of Radiation Pneumonitis by Recombinant Adenovirus-Mediated Transfer of Soluble TGF-bðtype II Receptor Gene Koichi Takayama, Haiping Zhang, Junji Uchino, Akiko Harada, Taishi Harada, Yoichi Nakanishi 365 Aerosol Delivery of an Enhanced Helper-Dependent Adenovirus Formulation to Rabbit Lung Using an Intratracheal Catheter David R. Koehler, Helena Frndova, Kitty Leung, Emily Louca, Donna Palmer, Philip Ng, Colin McKerlie, Peter Cox, Allan L. Coates, Jim Hu 366 Development of Quantitative TaqMan RT-PCR for the Evaluation of Non-Viral Mediated Gene Transfer to the Airways Ian A. Pringle, Rebecca L. Smith, Bryony L. Jones, Deborah R. Gill, Stephen C. Hyde
68 8th Annual Meeting • June 1 - 5, 2005 • St. Louis ABSTRACTS THURSDAY, JUNE 2 367 Safety and Immunological Responses Following Intrapleural Administration of an AAV5 Vector Encoding Human α1-Antitrypsin to Non-Human Primates Ben-Gary Harvey, Bishnu P. De, John P. Ayala, Neil R. Hackett, Adriana Heguy, Ronald Crystal Gene Regulation: Gene Targeting and RNA 368 Differential Sensitivity of Normal and CML-Derived CD34+ Cells to Inhibition of SHP2, Gab2 and Stat5 Gene Expression by RNA Interference (RNAi) Michaela Scherr, Karin Battmer, Anuhar Chaturvedi, Beate Schultheis, Arnold Ganser, Matthias Eder 369 Targeted Gene Modification Via Triple Helix-Forming Oligonucleotides Peter M. Glazer, Faye Rogers, Janice Lloyd 370 Multi-Copy, Multi-siRNA Vectors as Versatile Tools for Multiple Gene Knock-Down Applications Laura Poliseno, Monica Evangelista, Mauro Giacca, Giuseppe Rainaldi 371 Optimizing Custom Zinc-Finger Nucleases for Use in Human Cells Stephen Alwin, Maja B. Gere, Eva Guhl, Karin Effertz, Carlos F. Barbas III, David J. Segal, Matthew D. Weitzman, Toni Cathomen 372 Targeting of Non-Viral Vectors to Specific Subnuclear Domains Joshua Z. Gasiorowski, David A. Dean 373 Use of Lentiviral and Adeno-Associated Vectors for Targeted Gene Inactivation in Human Cancer Cells Sabrina Arena, Elisa Vigna, Luigi Naldini, Alberto Bardelli 374 Knockdown of Shp-2 Expression by siRNA in Mouse Embryonic Stem Cell Derived EB Cells Affects Their Hematopoietic Development Gang-Ming Zou, Rebecca J. Chan, W. Christopher Shelley, Mervin C. Yoder 375 Targeted Gene Repair Induces the DNA Damage Response Pathways through the Activation of ATM, and the Stalling of Replication Forks Leading to a Blockage of Inherited Correction Luciana Ferrara, Julia Engstrom, Erin Brachman, Miya Drury, Eric B. Kmiec 376 Various Aspects of the Single-Stranded DNA Fragment- Mediated Gene Correction Hiroyuki Tsuchiya, Hideyoshi Harashima, Hiroyuki Kamiya 377 Developing siRNAs to the E2Fs to Control Vascular Growth and Remodeling Paloma H. Giangrande, JianXin Zhang, Juliana Layzer, Otto Hagen, Joseph R. Nevins, Bruce A. Sullenger 378 Retargeting Mobile Group II Introns to Repair Mutant Genes Monique N. Kierlin, John P. Jones III, Rob G. Coon, Jiri Perutka, Alan M. Lambowitz, Bruce A. Sullenger 379 New Zinc Finger Protein Nuclease Architectures for More Efficient Gene Modification Therapies Jeffrey C. Miller, Lei Zhang, Fyodor D. Urnov, Sarah Patterson, Danny Xia, Jeremy Rock, Sheldon Augustus, Carl O. Pabo, Philip D. Gregory, Edward J. Rebar Michael C. Holmes 380 Studies on the Mechanism of Gene Repair Using Saccharomyces cerevisae as a Model System Katie Maguire, Hetal Parekh-Olmedo, Eric B. Kmiec 381 Methods for Optimizing Lentiviral Vector-Mediated Gene Suppression by RNA Interference Eddy Kizana, Genaro Ramirez, Eugenio Cingolani, Roselle Abraham, Eduardo Marban 382 Expanding the Repertoire of Heterospecific LoxP Sites for Cre-Mediated Site-Specific Recombination Stephen J. Langer, Jarred Keith, Leslie A. Leinwand 383 Zinc Finger Nuclease-Boosted Gene Targeting & Synergistic Transient Regenerative Stem Cell Gene Therapy: Toward Clinical Gene Repair/Alteration & Custom Site-Specific Integrative Gene Therapy Roger Bertolotti 384 Double-Stranded DNA Breaks Stimulate the Frequency of Targeted Gene Repair in Mammalian Cells Timothy Schwartz, Luciana Ferrara, Hetal Parekh-Olmedo, Eric B. Kmiec 385 Gene Correction in the Absence of DNA Repair: A Universal Model Involving Homologous Pairing and DNA Replication Hetal Parekh-Olmedo, Erin Brachman, Eric B. Kmiec
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156 NOTES 8th Annual Meeting • Ju
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FINAL PROGR AM - American Society of Gene & Cell Therapy

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