FINAL PROGR AM - American Society of Gene & Cell Therapy
FINAL PROGR AM - American Society of Gene & Cell Therapy
FINAL PROGR AM - American Society of Gene & Cell Therapy
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<strong>AM</strong>ERICAN SOCIETY OF GENE THERAPY • Final Program 63<br />
ABSTRACTS<br />
THURSDAY, JUNE 2<br />
283<br />
Suppression <strong>of</strong> Inflammatory Pathways Selectively<br />
Induced by Oncolytic Viruses Enhances Viral Oncolysis<br />
Giulia Fulci, Laura M. Breymann, Elizabeth J. Fontana,<br />
Davide Gianni, Hiroaki Wakimoto, Ralph Weissleder, Robert<br />
Lee, Quing Liu, Antonio E. Chiocca<br />
284<br />
CD137L <strong>Gene</strong> Transfer <strong>Gene</strong>rates Effective and Long-<br />
Lasting Immunity in a Murine Plasmocytoma Model<br />
Young Kim, John W. Strehl, Marcus Gorschluter, Carsten Ziske,<br />
Christine Mayr, Ingo G. H. Schmidt-Wolf<br />
285<br />
Anti-Tumor Immune Responses Following Neoadjuvant<br />
Immunotherapy with a Recombinant Adenovirus<br />
Expressing HSP72 to Rodent Tumors<br />
James A. Krewet, Si-Yi Chen, Maulik R. Shah<br />
Cancer-Apoptosis and Suicide<br />
286<br />
Therapeutic Approach Using External Radiation and<br />
Suicide <strong>Gene</strong> <strong>Therapy</strong> Transduced by Chimeric Adenovirus<br />
Vector for Bladder Cancer<br />
Kazumasa Matsumoto, Norihiko Okuno, Bin S. Teh, Christian<br />
T. F. Freund, Julie X. Zhu, Maria T. Vlachaki, Alan R.<br />
Davis, Brian E. Butler, Seth P. Lerner<br />
287<br />
mda-7: A Remedy for Oncogene Addiction in Breast<br />
Cancer?<br />
Sunil Chada, Yanna Liu, Dora Bocangel, Ming Zheng,<br />
Rajagopal Ramesh, Raymond Meyn, Kelly Hunt<br />
288<br />
A System for GMP Expansion and Transduction <strong>of</strong><br />
Human T <strong>Cell</strong>s with High Functionality Proven by<br />
Consistent Induction <strong>of</strong> GvHD in a Mouse<br />
Xenotransplant Model<br />
Gerhard Bauer, Jon Walker, Bruno Nervi, Julie Ritchey, Jackie<br />
Hughes, Bill Eades, Mark Bonyhadi, Jan Nolta, John DiPersio<br />
289<br />
Highly Inducible and Prostate Specific Oncolytic Adenovirus<br />
with E1A-AR Chimera<br />
Ying Li, Chien-Lun Chen, David C. Johns, Ronald Rodriguez<br />
290<br />
Alpha-Tocopherol Succinate (VES) Enhances Ad-mda7-<br />
Mediated Killing <strong>of</strong> Ovarian Cancer <strong>Cell</strong>s<br />
Manish Shanker, Sunil Chada, Rajagopal Ramesh<br />
291<br />
Comparison <strong>of</strong> Anti-Tumor Effects between Transmembrane<br />
and Secretory Tumor Necrosis Factor-alpha In Vitro<br />
and In Vivo<br />
Wenfang Shi, Qingfen Li, Zhuoya Li<br />
292<br />
Primary Chronic Lymphocytic Leukaemia <strong>Cell</strong>s Are<br />
Resistant to the Oncolytic Effects <strong>of</strong> Attenuated Measles<br />
Virus<br />
Matthew A. Bates, R. G. Wickremasinghe, Adele K. Fielding<br />
293<br />
Optimizing the Efficacy <strong>of</strong> Spliceosome-Mediated RNA<br />
Trans-Splicing (SMaRT) for Suicide <strong>Gene</strong> <strong>Therapy</strong> <strong>of</strong><br />
Cervical Cancer<br />
Michael Patrick, M. Puttaraju, Janet DiPasquale, Jesse Quintero,<br />
Yanping Yang, Mariano A. Garcia-Blanco, Lloyd G. Mitchell,<br />
Ed Otto, Carl C. Baker<br />
294<br />
Adenoviral-TRAIL and a Smac34-8K Fusion Peptide Act<br />
Synergistically to Induce Apoptosis in Low CAR-<br />
Expressing Human Glioma <strong>Cell</strong>s<br />
Hiroyuki Mushiake, Moira R. Hitchens, Jeffrey C. Mai, Dai-<br />
Wu Seol, Paul D. Robbins<br />
295<br />
Adeno-Associated Virus-Mediated Transfer <strong>of</strong> the <strong>Gene</strong>s<br />
Encoding Cryptic Kringle Fragments <strong>of</strong> Apolipoprotein<br />
(A) Suppresses Tumor Growth and Metastasis In Vivo<br />
Kyuhyun Lee, Sung-Tae Yun, Eui-Cheol Jo<br />
296<br />
Effective Suppression <strong>of</strong> Breast Cancer by<br />
Downregulation <strong>of</strong> VEGF Signaling<br />
Yi Lu, Jun Zhang, Derrick J. Beech, Lisa K. Jennings<br />
297<br />
Radiovirotherapy in Ovarian Cancer Using Recombinant<br />
Measles Expressing Sodium Iodide Symporter<br />
Kosei Hasegawa, Hooi-Tin Ong, David Dingli, Takafumi<br />
Nakamura, Stephen J. Russell, Kah Whye Peng<br />
298<br />
<strong>Gene</strong> <strong>Therapy</strong> Against Prostate Cancer Using the HSVtk/Prodrug<br />
System Followed by Prostatectomy<br />
Augusto Rojas-Martinez, Laura K. Aguilar, Rocio Ortiz-<br />
Lopez, Jacinto Esteban-Maria, Juan F. Gonzalez-Guerrero,<br />
Raquel Garza-Guajardo, Juan P. Flores-Gutierrez, E. Brian<br />
Butler, Hugo A. Barrera-Saldana, Estuardo Aguilar-Cordova<br />
299<br />
Increasing <strong>Gene</strong> Transfer and Oncolytic Potency <strong>of</strong><br />
Adenoviruses in Orthotopic Models <strong>of</strong> Gastric Cancer<br />
Lotta Kangasniemi, Anna Kanerva, Mari Raki, Tuuli Ranki,<br />
Merja Sarkioja, Tuula Kiviluoto, Ulf-Hakan Stenman, Henrik<br />
Alfthan, Hongju Wu, David T. Curiel Akseli Hemminki<br />
300<br />
Adenoviral Delivery <strong>of</strong> the <strong>Gene</strong> Encoding Secretable<br />
Trimeric TRAIL Induces Apoptosis and Suppresses<br />
Human Malignant Glioma In Vivo<br />
Moonsup Jeong, In-Ho Kwon, Chae-Young Kim, Dai-Wu<br />
Seol, Paul D. Robbins, Byong-Moon Kim
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