FINAL PROGR AM - American Society of Gene & Cell Therapy
FINAL PROGR AM - American Society of Gene & Cell Therapy
FINAL PROGR AM - American Society of Gene & Cell Therapy
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56<br />
8th Annual Meeting • June 1 - 5, 2005 • St. Louis<br />
ABSTRACTS<br />
THURSDAY, JUNE 2<br />
159<br />
Unexpected <strong>Gene</strong>tic Alterations Occur in Untargeted<br />
<strong>Gene</strong>s during the Construction <strong>of</strong> Viral Vectors<br />
Megan J. Dambach, Jordan Trecki, Natalia Martin, Nancy S.<br />
Markovitz<br />
160<br />
Systemic Oncolytic Herpes Simplex Virus <strong>Therapy</strong> <strong>of</strong><br />
Spontaneously Arising Prostate Cancer in Transgenic<br />
TR<strong>AM</strong>P Mice<br />
Susan Varghese, Samuel D. Rabkin, Petur G. Nielsen, Renbin<br />
Liu, Wenzheng Wang, Robert L. Martuza<br />
161<br />
Targeting HSV Infection to gD Receptor-Negative <strong>Cell</strong>s<br />
Using Soluble gD Receptors<br />
Heechung Kwon, Qing Bai, Kelly Felmet, Hyun-Jung Baek,<br />
Gyuyoup Kim, William F. Goins, Justus B. Cohen, Joseph C.<br />
Glorioso<br />
162<br />
Targeted HSV-1 Infection by Adapters for Glycoprotein<br />
D: Variable Infection Efficiency Dependent on Ligand<br />
Choice<br />
Kenji Nakano, William F. Goins, Justus B. Cohen, Joseph C.<br />
Glorioso<br />
163<br />
Engineered <strong>of</strong> a Highly Efficient <strong>Cell</strong> Cycle Regulatable-<br />
HSV-1 Amplicon Viral Vector<br />
Grace Ying Wang, Ivy A. W. Ho, Kam M. Hui, Paula Y. P.<br />
Lam<br />
164<br />
Bioluminescence Imaging in the CNS after HSV<br />
Amplicon Vector Delivery<br />
Sam Wang, Lisa Pike, Jeremy Petravicz, Xandra O. Breakefield<br />
165<br />
Tracking <strong>of</strong> Baculovirus Biodistribution In Vivo by<br />
Magnetic Resonance Imaging<br />
Jani K. Raty, Thomas Wirth, Kari J. Airenne, Tuulia Huhtala,<br />
Timo Liimatainen, Ale Narvanen, Juhana Hakumaki, Seppo<br />
Yla-Herttuala<br />
166<br />
Recombinant Baculovirus Vectors Containing Inverted<br />
Terminal Repeats from Adeno-Associated Virus Improve<br />
<strong>Gene</strong> Expression in Neurons and Astrocytes<br />
Cao Yang Wang, Shu Wang<br />
167<br />
Both Oncolysis and Tumor Immunity Are Involved in an<br />
Autitumoral Efficacy by Intratumoral Injection <strong>of</strong><br />
Recombinant Vaccinia Virus (TK Deleted, hGM-CSF<br />
Inserted Wyeth Strain) in a VX2 Rabbit Model<br />
Joon-Hyeong Kim, Byeong-Ho Park, Jong-Young Oh, David<br />
H. Kirn, Steve H. Thorne, Jae-Seok Kim, Tae-Ho Hwang<br />
168<br />
Antitumoral Efficacy <strong>of</strong> Multiple Injection <strong>of</strong> JX-594<br />
(Thymidine Kinase (TK) Deleted, Human GM-CSF<br />
Inserted Wyeth Strain) Via Tail Vein in N-<br />
Nitrosomorpholine (NNM) Treated Rats<br />
Jae-seok Kim, June-Hyung Kim, Jong-yeong Oh, Byeong-ho<br />
Park, Jin-Han Yoon, Steve H. Thorne, David H. Kirn, Tae-ho<br />
Hwang<br />
169<br />
The Creation <strong>of</strong> Novel Oncolytic Vaccinia Virus Vectors<br />
for Efficient Systemic Delivery <strong>of</strong> Transgenes to Tumors<br />
Steve H. Thorne, David H. Kirn<br />
170<br />
In Vitro Transduction <strong>of</strong> <strong>Cell</strong>s To Determine Tropism<br />
Using Viral-Like Particles Derived from JC Virus VP1<br />
Linda Cashion, Oliver Ast, Andrzej Citkowicz, Susan Harvey,<br />
Branka Mitrovic, Mary Rose Masikat, Katalin Kauser, Brent<br />
Larsen, Gabor M. Rubanyi, Richard N. Harkins Harald Petry<br />
171<br />
Changing <strong>of</strong> Viral Tropism Alters Natural Proviral<br />
Property: Implications for Viral Vector Design<br />
Peng H. Tan, Shoa-An Xue, Hans J. Stuass, George J. T.<br />
George<br />
172<br />
In Vitro DNA Packaging and <strong>Gene</strong> Delivery Using JC<br />
Virus-Like Particles<br />
Oliver Ast, Andrezj Citkowicz, Linda Cashion, Brent Larsen,<br />
Gabor M. Rubanyi, Richard N. Harkins, Harald Petry<br />
173<br />
Process Design and Scale-Up <strong>of</strong> New Vaccine Concepts<br />
for Biodefense<br />
Sibylle U. Herzer, Peder Bergvall, Raf Lemmens, Matt C<strong>of</strong>fey,<br />
Walter T. Leps, Peter M. Moore<br />
174<br />
Process Development <strong>of</strong> a Scaleable Purification Protocol<br />
for the Production <strong>of</strong> Reolysin, an Oncolytic, Reovirus-<br />
Based Therapeutic<br />
Sibylle U. Herzer, Bergvall Peder, Lemmens Raf, C<strong>of</strong>fey Matt,<br />
Moore M. Peter<br />
175<br />
Titering <strong>Gene</strong> Delivery Vectors by QPCR: Application to<br />
rSV40-Derived Vectors<br />
Christine B. Mitchell, David S. Strayer<br />
Naked DNA <strong>Gene</strong> Transfer: Chromosomal, Integration,<br />
Delivery Techniques<br />
176<br />
Target-Site Preferences <strong>of</strong> Sleeping Beauty Transposons<br />
in an Intron <strong>of</strong> the B-raf Oncogene<br />
Jason B. Bell, Christopher S. Hackett, Aron M. Geurts, Corey<br />
M. Carlson, Lara S. Collier, Geyi Liu, David A. Largaespada,<br />
Perry B. Hackett
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