FINAL PROGR AM - American Society of Gene & Cell Therapy
FINAL PROGR AM - American Society of Gene & Cell Therapy
FINAL PROGR AM - American Society of Gene & Cell Therapy
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<strong>AM</strong>ERICAN SOCIETY OF GENE THERAPY • Final Program 55<br />
ABSTRACTS<br />
THURSDAY, JUNE 2<br />
143<br />
Regulated, High Capacity Adenoviral Vectors Mediated<br />
Long-Term <strong>Gene</strong> Expression in the Brain Even in the<br />
Presence <strong>of</strong> a Peripheral Immune Response to Adenovirus<br />
Weidong Xiong, Shyam Goverdhana, James F. Curtin, Carlos<br />
Barcia-Gonzalez, Jeffrey M. Zirger, Gwendalyn D. King,<br />
Sandra A. Sciascia, Mariana Puntel, Marianela Candolfi,<br />
Donna Palmer Philip Ng, Pedro R. Lowenstein, Maria G.<br />
Castro<br />
144<br />
In Vivo Studies on the Toxicity <strong>of</strong> Adenovirus Vectors for<br />
Kupffer <strong>Cell</strong>s<br />
Elanchezhiyan Manickan, Jeffrey S. Smith, Jie Tian, Andrew P.<br />
Byrnes<br />
145<br />
Evaluation <strong>of</strong> Biodistribution and Safety <strong>of</strong> Adenovirus<br />
Vectors Containing B-Group Fibers after Intravenous<br />
Injection into Baboons<br />
Shaoheng Ni, Kathrin Bernt, Zong-Yi Li, Hans-Peter Kiem,<br />
Andre Lieber<br />
146<br />
T <strong>Cell</strong> Response Against the Cystic Fibrosis Transmembrane<br />
Conductance Regulator (CFTR) <strong>Gene</strong><br />
Maria Limberis, Joanita Figueredo, James M. Wilson<br />
147<br />
Adenovirus Vector E4 <strong>Gene</strong> Regulates Connexin 40 and<br />
43 Expression in Endothelial <strong>Cell</strong>s Via PKA and PI3K<br />
Signal Pathways<br />
Joseph Cheng, Fan Zhang, George Lam, David Jin, Loic<br />
Vincent, Neil R. Hackett, Shiyang Wang, Lauren M. Young,<br />
Barbara Hempstead, Ronald G. Crystal Shahin Rafii<br />
148<br />
The Transgene Cassette Is Not Fully Responsible for<br />
Alterations <strong>of</strong> Renal Cytochrome P450 Expression after<br />
Systemic Administration <strong>of</strong> Recombinant Adenovirus<br />
Hong T. Le, Michael P. Boquet, Erin A. Clark, Shellie M.<br />
Callahan, Maria A. Croyle<br />
149<br />
Transient Kupffer <strong>Cell</strong> Saturation, Via Adenovirus or<br />
Adenoviral Protein, Enhances Expression <strong>of</strong> Reporter<br />
Virus<br />
Viraj P. Mane, Christian Clarke, Lali Medina-Kauwe, Milton<br />
Finegold, Brendan Lee<br />
150<br />
Pre-Existing Nab and Neutralization <strong>of</strong> Therapeutic<br />
Dose Adenovirus Serotypes In Vitro<br />
Edward C. Nwanegbo, Wentao Gao, Andrea Gambotto, Paul<br />
Robbins<br />
151<br />
Evaluation <strong>of</strong> a Serotype 35 Fiber Containing Adenovirus<br />
Vector for Vaccination<br />
Nelson C. Di Paolo, Shaoheng Ni, Anuj Gaggar, Zong-Yi Li,<br />
Andre Lieber<br />
152<br />
Coxsackievirus-Adenovirus Receptor (CAR) and α β or v 3<br />
α β Integrin Independent Internalization <strong>of</strong> Porcine<br />
v 5<br />
Adenoviral Vectors: Implications in <strong>Gene</strong> <strong>Therapy</strong><br />
Dinesh S. Bangari, Suresh K. Mittal<br />
153<br />
Adenoviral <strong>Gene</strong> <strong>Therapy</strong> Vectors Expressing the<br />
Adenovirus Death Protein Demonstrate Increased<br />
Transgene Expression In Vivo as Demonstrated by Dose-<br />
Volume Histogram Analysis <strong>of</strong> Reporter <strong>Gene</strong> Activity<br />
Kenneth N. Barton, Stephen L. Brown, Jae Ho Kim, Hans<br />
Stricker, Kastytis Karvelis, Mei Lu, Svend O. Freytag<br />
154<br />
Relationship between the Expression <strong>of</strong> Membrane<br />
Receptors (CAR, Integrin aðvbð3 and Integrin aðvbð5 )<br />
and Adenoviral Transduction Efficiency<br />
Hiroyuki Inoue, Terumasa Hisano, Yukoh Nakazaki, Gaku<br />
Sakaguchi, Ryo Kurita, Koichi Takayama, Yoichi Nakanishi,<br />
Kenzaburo Tani<br />
“Other” DNA Virus Vectors<br />
155<br />
Oral Delivery <strong>of</strong> Recombinant Vaccinia Viruses Expressing<br />
Adjuvanted Islet Autoantigens Protects NOD Mice<br />
from Autoimmune Diabetes<br />
William H. R. Langridge, Bela Denes, Nadia Fodor, Valentina<br />
Krausova, Tatyana Timiryasova, David Henderson, John<br />
Hough, Jie Yu, Istvan Fodor<br />
156<br />
Update on Genomic HSV Vector-Related Cytotoxicity: A<br />
Vector Preserving the Differentiation Potential <strong>of</strong><br />
Embryonic and Adult Adipose Stem <strong>Cell</strong>s<br />
Julie Fradette, Steven K. Wendell, Jim Wechuck, David M.<br />
Krisky, Darren Wolfe, William F. Goins, Joseph C. Glorioso<br />
157<br />
Quantitation <strong>of</strong> Long-Term <strong>Gene</strong> Expression from the<br />
HSV-1 Latency-Associated Promoter in the Mouse Brain<br />
Following Intracranial Injection<br />
Bradford K. Berges, Ananya Gupta, John H. Wolfe, Nigel W.<br />
Fraser<br />
158<br />
<strong>Gene</strong> <strong>Therapy</strong> for Chronic Pain Control: Perspectives <strong>of</strong><br />
HSV-1 Mediated <strong>Gene</strong> Transfer to Supraspinal Centres<br />
Isabel Martins, Marta Pinto, Steven Wilson, Deolinda Lima,<br />
Isaura Tavares
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