FINAL PROGR AM - American Society of Gene & Cell Therapy
FINAL PROGR AM - American Society of Gene & Cell Therapy
FINAL PROGR AM - American Society of Gene & Cell Therapy
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<strong>AM</strong>ERICAN SOCIETY OF GENE THERAPY • Final Program 51<br />
ABSTRACTS<br />
THURSDAY, JUNE 2<br />
78 4:15 PM<br />
Expression <strong>of</strong> the Herpes Simplex Virus Thymidine<br />
Kinase <strong>Gene</strong> by a Promoter Region <strong>of</strong> the Human<br />
SPARC <strong>Gene</strong> Inhibits Human Melanoma <strong>Cell</strong> Growth In<br />
Vitro and In Vivo<br />
Maria V. Lopez, Patricia V. Blanco, Diego L. Viale, Eduardo A.<br />
Cafferata, David Gould, Yuti Chernajovsky, Osvaldo Podhajcer<br />
Oral Abstract Session 248<br />
<strong>Gene</strong> Regulation: Keeping <strong>Gene</strong>s On and Turning<br />
Them Off<br />
Room: 261/262<br />
79 2:00 PM<br />
Real Time Fluorescent Tracking <strong>of</strong> Dynamic Variegation<br />
by Retrovirus Vectors in Stem <strong>Cell</strong>s<br />
James Ellis, John Ramunas, Liam Kelly, Tanya Sukonnik, Eric<br />
Jervis<br />
80 2:15 PM<br />
Insulation <strong>of</strong> Oncoretrovirus Vectors with the cHS4<br />
Chromatin Insulator Is Associated with an Open Chromatin<br />
Histone Code<br />
Changlong Li, David W. Emery<br />
81 2:30 PM<br />
A Retrovirus Vector Screen for the Identification <strong>of</strong><br />
Novel Chromatin Insulators and Enhancers<br />
Amy C. Groth, George Stamatoyannopoulos, David W. Emery<br />
82 2:45 PM<br />
Targeted Pancreatic Cancer-Specific <strong>Gene</strong> <strong>Therapy</strong><br />
Controlled by a Molecular-Engineered Human Cholecystokinin<br />
Type-A Receptor (CCKAR) Promoter in In<br />
Vivo Imaging Models<br />
Xiaoming Xie, Zheng Li, Qingqing Ding, Hus-Ping Kuo,<br />
James L. Abbruzzese, Mien-Chie Hung<br />
83 3:00 PM<br />
Persistent and Position Independent Transgene Expression<br />
in Erythroid <strong>Cell</strong>s Transduced by Lentiviral Vectors<br />
Annarita Miccio, Francesco Lotti, Claudia Rossi, Giuliana<br />
Ferrari<br />
84 3:15 PM<br />
Assessing Hemostatic Efficacy <strong>of</strong> Continuous Expression<br />
<strong>of</strong> Factor VIIa after AAV-Mediated, Liver-Directed <strong>Gene</strong><br />
Transfer in Hemophilia A and B Mice<br />
Alexander Schlachterman, Paris Margaritis, Majed Aljamali,<br />
Jianhua Liu, Valder Arruda, Katherine High<br />
85 3:30 PM<br />
Development <strong>of</strong> Zinc Finger Nucleases for Therapeutic<br />
<strong>Gene</strong> Correction <strong>of</strong> Sickle <strong>Cell</strong> Anemia<br />
Jeffrey C. Miller, Fyodor D. Urnov, Ya-li Lee, Jeremy Rock,<br />
Tyler Sorba, Sarah Patterson, Philip D. Gregory, Michael C.<br />
Holmes, Edward J. Rebar<br />
86 3:45 PM<br />
Transcriptional <strong>Gene</strong> Silencing in Human <strong>Cell</strong>s<br />
Zhaoxia Chen, Ali Ehsani, Riggs Art, Rossi J. John, Kevin V.<br />
Morris<br />
87 4:00 PM<br />
Determinants <strong>of</strong> Toxicity Induced by In Vivo Expression<br />
<strong>of</strong> Short Hairpin RNA from AAV Vectors<br />
Dirk Grimm, Konrad L. Streetz, Kusum Pandey, Theresa A.<br />
Storm, Mark A. Kay<br />
88 4:15 PM<br />
Driving shRNA Transcription from PolII Promoters in<br />
Mammalian <strong>Cell</strong>s<br />
Jeffery C. Giering, Mark A. Kay<br />
Poster Session I<br />
Exhibit Hall 2<br />
RNA Virus Vectors: <strong>Gene</strong> Expression<br />
89<br />
Amelioration <strong>of</strong> Gamma Retroviral Silencing during<br />
Embryonic Stem <strong>Cell</strong>-Derived Hematopoiesis: Preclinical<br />
Assessment <strong>of</strong> Safety-Improved Vectors<br />
Ali Ramezani, Teresa S. Hawley, Robert G. Hawley<br />
90<br />
In Vitro and In Vivo <strong>Gene</strong> Expression <strong>of</strong> Lentiviral<br />
Vectors in CD4+ T <strong>Cell</strong>s<br />
Kit L. Shaw, Karen Pepper, Denise Petersen, Vesa Kaartinen,<br />
Donald B. Kohn<br />
91<br />
Insertion <strong>of</strong> the cHS4-Insulator into Lentiviral Vectors:<br />
Use <strong>of</strong> Real-Time PCR in Order To Analyze the Effects<br />
on Transgene Expression and Viral Titre<br />
Johan Jakobsson, Troels Tolstrup Nielsen, Nina Rosenqvist,<br />
Cecilia Lundberg<br />
92<br />
Efficient Trangene Expression in Central Nervous System<br />
through a Non-Integrative Lentiviral Vector<br />
Stephanie Philippe, Che Serguera, Sebastien Bonnel, Christelle<br />
Vetu, Martine Barkats, Caroline Petit, Marc Abitbol, Chamsy<br />
Sarkis, Jacques Mallet<br />
93<br />
Diminished Mobilization <strong>of</strong> Self-Inactivating (SIN)<br />
Lentiviral Vectors Containing Globin Regulatory Elements<br />
Compared to Those Containing a Retroviral Long<br />
Terminal Repeat<br />
Hideki Hanawa, Derek A. Persons, Takashi Shimada, Arthur<br />
W. Nienhuis<br />
94<br />
Transgene Expression with Integration-Deficient HIV-1<br />
Based Lentiviral Vectors Expressing Class I Integrase<br />
Mutants<br />
G. Joseph, J. Marsh, T. Johnson, K. Cornetta
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