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FINAL PROGR AM - American Society of Gene & Cell Therapy

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<strong>AM</strong>ERICAN SOCIETY OF GENE THERAPY • Final Program 47<br />

ABSTRACTS<br />

THURSDAY, JUNE 2<br />

18 3:45 PM<br />

Facilitation <strong>of</strong> AAV Genome Circularization by Host <strong>Cell</strong><br />

Factors Involved in DNA Replication and Double-Strand<br />

Break Repair<br />

Vivian W. Choi, Douglas M. McCarty, Richard J. Samulski<br />

19 4:00 PM<br />

rAAV-2 Transduction <strong>of</strong> Primitive Human Hematopoietic<br />

Stem <strong>Cell</strong>s Capable <strong>of</strong> Serial Engraftment in Immune<br />

Deficient Mice<br />

Helicia Paz, Leah Santat, Lijing Li, Christie Wong, Stephen J.<br />

Forman, K. K. Wong, Saswati Chatterjee<br />

20 4:15 PM<br />

Targeted <strong>Gene</strong> Delivery to Embryonic Stem <strong>Cell</strong>s<br />

Els Henckaerts, Nadja Zeltner, Steven Kattman, Nathalie<br />

Dutheil, Peter Ward, Marion Kennedy, Nathalie Clement,<br />

Patricia Rebollo, Gordon Keller, R. Michael Linden<br />

Oral Abstract Session 242<br />

Adenovirus Vectors: Vector Technology<br />

Room: Ferrara Theater<br />

21 2:00 PM<br />

Application <strong>of</strong> Splice Acceptor Transposons to the<br />

Development <strong>of</strong> Oncolytic Viruses<br />

Fang Jin, Peter Kretschmer, Cecile Chartier, Irene Kuhn, Terry<br />

Hermiston<br />

22 2:15 PM<br />

<strong>Gene</strong>ration <strong>of</strong> Circular Sleeping Beauty DNA Transposition<br />

Substrates by RU486-Induced Flp Recombination In<br />

Vitro – Steps towards a Single Integrating Adeno-<br />

Transposon Vector<br />

Jacob G. Mikkelsen, Stephen R. Yant, Anja Ehrhardt, Mark A.<br />

Kay<br />

23 2:30 PM<br />

Frequency <strong>of</strong> Random and Targeted Chromosomal<br />

Integration <strong>of</strong> Helper-Dependent Adenoviral Vector<br />

Fumi Ohbayashi, Emi Aizawa, Atshuhiro Kishimoto, Ko<br />

Mitani<br />

24 2:45 PM<br />

Context-Specific Peptide-Presenting Phage Libraries for<br />

Adenoviral Vector Targeting<br />

Debadyuti Ghosh, Michael A. Barry<br />

25 3:00 PM<br />

<strong>Gene</strong>tic Incorporation <strong>of</strong> HSV-1 Thymidine Kinase into<br />

the Adenovirus Protein IX for Functional Display on the<br />

Virion<br />

Jing Li, Long Le, Don A. Sibley, J. Michael Mathis, David T.<br />

Curiel<br />

26 3:15 PM<br />

Microsphere Delivery <strong>of</strong> Adenoviral-Liposome Complexes<br />

Reduces Adenoviral Immunogenicity and Allows<br />

Successful Re-Administration <strong>of</strong> the Virus without Loss<br />

<strong>of</strong> <strong>Gene</strong> Expression Efficiency<br />

Jason C. Steel, John C. Morris, Mark A. Burton, Heather M.<br />

A. Cavanagh, Wouter H. J. Kalle<br />

27 3:30 PM<br />

A Novel “<strong>Gene</strong>ti-Chemical” Platform for Flexible and<br />

Efficient De- and Retargeting <strong>of</strong> Adenovirus Vector<br />

Particles<br />

Florian Kreppel, Judith Gackowski, Erika Schmidt, Stefan<br />

Kochanek<br />

28 3:45 PM<br />

Adenovirus Targeting Via Leucine Zipper Peptide-<br />

Mediated Ligand Attachment<br />

Joel N. Glasgow, Nikolay Korokhov, David T. Curiel<br />

29 4:00 PM<br />

Redirection <strong>of</strong> Adenoviral Tropism through Capsomers<br />

Other Than Fiber Is <strong>Gene</strong>rally Inefficient and Dependent<br />

on Ligand-Receptor Biology<br />

Samuel K. Campos, Michael A. Barry<br />

30 4:15 PM<br />

AdenoLibrary for Construction and Selection <strong>of</strong> Targeted<br />

Adenoviruses<br />

Sam C. Noureddini, Alexander Krendelshchikov, Vera<br />

Simonenko, Joanne T. Douglas, David T. Curiel, Nikolay<br />

Korokhov<br />

Oral Abstract Session 243<br />

Inborn Errors <strong>of</strong> Metabolism - Stem <strong>Cell</strong>s and Blood<br />

Disorders<br />

Room: 120/124<br />

31 2:00 PM<br />

Somatic <strong>Gene</strong> <strong>Therapy</strong> for ADA-SCID Following<br />

Cessation <strong>of</strong> PEG-ADA and Use <strong>of</strong> a Mild Conditioning<br />

Regime<br />

Hubert B. Gaspar, Emma Bjorkegren, Katherine Parsley,<br />

Kimberly C. Gilmour, Jo Sinclair, Fang Zhang, Lynette D.<br />

Fairbanks, Doug King, Graham Davies, Paul A. Veys Christine<br />

Kinnon, Adrian J. Thrasher<br />

32 2:15 PM<br />

Tolerance after Neonatal <strong>Gene</strong> Transfer <strong>of</strong> a Human<br />

Factor IX-Expressing Retroviral Vector May Involve<br />

Clonal Deletion in C3H Mice and Is Effective in Hemophilia<br />

B Dogs<br />

Lingfei Xu, Mark E. Haskins, Timothy C. Nichols, Manxue<br />

Mei, Patty O’Donnell, Dwight A. Bellinger, Stephanie<br />

McCorquodale, Katherine P. Ponder

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