FINAL PROGR AM - American Society of Gene & Cell Therapy
FINAL PROGR AM - American Society of Gene & Cell Therapy
FINAL PROGR AM - American Society of Gene & Cell Therapy
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<strong>AM</strong>ERICAN SOCIETY OF GENE THERAPY • Final Program 47<br />
ABSTRACTS<br />
THURSDAY, JUNE 2<br />
18 3:45 PM<br />
Facilitation <strong>of</strong> AAV Genome Circularization by Host <strong>Cell</strong><br />
Factors Involved in DNA Replication and Double-Strand<br />
Break Repair<br />
Vivian W. Choi, Douglas M. McCarty, Richard J. Samulski<br />
19 4:00 PM<br />
rAAV-2 Transduction <strong>of</strong> Primitive Human Hematopoietic<br />
Stem <strong>Cell</strong>s Capable <strong>of</strong> Serial Engraftment in Immune<br />
Deficient Mice<br />
Helicia Paz, Leah Santat, Lijing Li, Christie Wong, Stephen J.<br />
Forman, K. K. Wong, Saswati Chatterjee<br />
20 4:15 PM<br />
Targeted <strong>Gene</strong> Delivery to Embryonic Stem <strong>Cell</strong>s<br />
Els Henckaerts, Nadja Zeltner, Steven Kattman, Nathalie<br />
Dutheil, Peter Ward, Marion Kennedy, Nathalie Clement,<br />
Patricia Rebollo, Gordon Keller, R. Michael Linden<br />
Oral Abstract Session 242<br />
Adenovirus Vectors: Vector Technology<br />
Room: Ferrara Theater<br />
21 2:00 PM<br />
Application <strong>of</strong> Splice Acceptor Transposons to the<br />
Development <strong>of</strong> Oncolytic Viruses<br />
Fang Jin, Peter Kretschmer, Cecile Chartier, Irene Kuhn, Terry<br />
Hermiston<br />
22 2:15 PM<br />
<strong>Gene</strong>ration <strong>of</strong> Circular Sleeping Beauty DNA Transposition<br />
Substrates by RU486-Induced Flp Recombination In<br />
Vitro – Steps towards a Single Integrating Adeno-<br />
Transposon Vector<br />
Jacob G. Mikkelsen, Stephen R. Yant, Anja Ehrhardt, Mark A.<br />
Kay<br />
23 2:30 PM<br />
Frequency <strong>of</strong> Random and Targeted Chromosomal<br />
Integration <strong>of</strong> Helper-Dependent Adenoviral Vector<br />
Fumi Ohbayashi, Emi Aizawa, Atshuhiro Kishimoto, Ko<br />
Mitani<br />
24 2:45 PM<br />
Context-Specific Peptide-Presenting Phage Libraries for<br />
Adenoviral Vector Targeting<br />
Debadyuti Ghosh, Michael A. Barry<br />
25 3:00 PM<br />
<strong>Gene</strong>tic Incorporation <strong>of</strong> HSV-1 Thymidine Kinase into<br />
the Adenovirus Protein IX for Functional Display on the<br />
Virion<br />
Jing Li, Long Le, Don A. Sibley, J. Michael Mathis, David T.<br />
Curiel<br />
26 3:15 PM<br />
Microsphere Delivery <strong>of</strong> Adenoviral-Liposome Complexes<br />
Reduces Adenoviral Immunogenicity and Allows<br />
Successful Re-Administration <strong>of</strong> the Virus without Loss<br />
<strong>of</strong> <strong>Gene</strong> Expression Efficiency<br />
Jason C. Steel, John C. Morris, Mark A. Burton, Heather M.<br />
A. Cavanagh, Wouter H. J. Kalle<br />
27 3:30 PM<br />
A Novel “<strong>Gene</strong>ti-Chemical” Platform for Flexible and<br />
Efficient De- and Retargeting <strong>of</strong> Adenovirus Vector<br />
Particles<br />
Florian Kreppel, Judith Gackowski, Erika Schmidt, Stefan<br />
Kochanek<br />
28 3:45 PM<br />
Adenovirus Targeting Via Leucine Zipper Peptide-<br />
Mediated Ligand Attachment<br />
Joel N. Glasgow, Nikolay Korokhov, David T. Curiel<br />
29 4:00 PM<br />
Redirection <strong>of</strong> Adenoviral Tropism through Capsomers<br />
Other Than Fiber Is <strong>Gene</strong>rally Inefficient and Dependent<br />
on Ligand-Receptor Biology<br />
Samuel K. Campos, Michael A. Barry<br />
30 4:15 PM<br />
AdenoLibrary for Construction and Selection <strong>of</strong> Targeted<br />
Adenoviruses<br />
Sam C. Noureddini, Alexander Krendelshchikov, Vera<br />
Simonenko, Joanne T. Douglas, David T. Curiel, Nikolay<br />
Korokhov<br />
Oral Abstract Session 243<br />
Inborn Errors <strong>of</strong> Metabolism - Stem <strong>Cell</strong>s and Blood<br />
Disorders<br />
Room: 120/124<br />
31 2:00 PM<br />
Somatic <strong>Gene</strong> <strong>Therapy</strong> for ADA-SCID Following<br />
Cessation <strong>of</strong> PEG-ADA and Use <strong>of</strong> a Mild Conditioning<br />
Regime<br />
Hubert B. Gaspar, Emma Bjorkegren, Katherine Parsley,<br />
Kimberly C. Gilmour, Jo Sinclair, Fang Zhang, Lynette D.<br />
Fairbanks, Doug King, Graham Davies, Paul A. Veys Christine<br />
Kinnon, Adrian J. Thrasher<br />
32 2:15 PM<br />
Tolerance after Neonatal <strong>Gene</strong> Transfer <strong>of</strong> a Human<br />
Factor IX-Expressing Retroviral Vector May Involve<br />
Clonal Deletion in C3H Mice and Is Effective in Hemophilia<br />
B Dogs<br />
Lingfei Xu, Mark E. Haskins, Timothy C. Nichols, Manxue<br />
Mei, Patty O’Donnell, Dwight A. Bellinger, Stephanie<br />
McCorquodale, Katherine P. Ponder