FINAL PROGR AM - American Society of Gene & Cell Therapy

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AMERICAN SOCIETY OF GENE THERAPY • Final Program 31 SCIENTIFIC PROGRAM THURSDAY, JUNE 2, 2005 Workshop 217 Viral: Key Design Issues for Oncolytic Vectors Room: 240 Complex Chair: Samuel D. Rabkin, PhD Speakers: David L. Bartlett, MD - Options for Creating Mutant Poxviruses for Oncolytic Therapy Noriyuki Kasahara, MD, PhD - Building a Better Mouse Virus: Design Strategies to Improve Therapeutic Efficacy and Safety of Replicationcompetent Retrovirus (RCR) Vectors for Cancer Gene Therapy John C. Bell, PhD - VSV as an Oncolytic Agent Stephen J. Russell, MD, PhD - Retargeting Attachment and Entry of Oncolytic Viruses William S. M. Wold, PhD - Oncolytic Adenovirus Vectors that Overexpress ADP Samuel D. Rabkin, PhD - Oncolytic Herpes Simplex Virus (HSV) Vectors BREAK – 10:45 AM - 11:00 AM WORKSHOPS – 11:00 AM - 12:30 PM Workshop 220 Cardiovascular Gene Therapy: From Bench to Bedside Room: 120/124 Co-Chairs: Anthony Rosenzweig, MD Roger J. Hajjar, MD Speakers: Albert J. Sinusas, MD - Imaging of Angiogenesis and Gene Therapy In Vivo R. Jude Samulski, PhD - Biological Nanoparticles: The Next Generation of Efficient Delivery Reagents David Kaye, FRACP, PhD, FACC - Percutaneous Approaches to Cardiac Gene Transfer Roger J. Hajjar, MD - The Road from Physiological Observation to Gene Therapy in Patients with Heart Failure Workshop 221 Clinical and Regulatory Affairs: Cell and Gene Based Cancer Vaccines Room: 263/267 Chair: Dale Ando, MD Speakers: Karin Jooss, PhD - Combination Therapy of a GM-CSF Secreting Tumor Cell Vaccine and anti-CTLA-4: Preclinical Evaluation and Tox Studies Drew Pardoll, MD, PhD - Targeting Immune Responses to Sites of Cancer Using Engineered Viruses and Bacteria Stephen J. Russell, MD, PhD - Noninvasive Expression Monitoring of Oncolytic Viruses in Phase I Clinical Trials Workshop 222 Genetic Diseases: Focus on the Metabolic Diseases of the Liver Room: 265/266 Chair: Jayanta Roy-Chowdhury, MD Speakers: Markus Grompe, MD - Strategies to Select Hepatocytes In Vivo Cary Harding, MD - Gene and Cell-mediated Therapeutic Approaches to Phenyckeonuria Jayanta Roy-Chowdhury, MD - SV40-based Vectors for Metabolic Diseases of the Liver and Beyond Brendan Lee, MD, PhD - Helper-dependent Adenoviral Gene Therapy for Metabolic Liver Diseases Workshop 223 Infectious Disease: Innate Immunity and Vector Function Room: 123/127 Co-Chairs: Bruce L. Levine, PhD John A. Zaia, MD Speakers: Hildegund CJ Ertl, MD - Innate Immunity to Adenovirus Bryan Williams, PhD - Synergistic Activation of Innate Immunity by Double-stranded RNA and CpG DNA Bruce E. Torbett, PhD, MSPH - Are Viral-based Vectors and Their Payloads Seen as Pathogens? Hua Yu, PhD - Stat3 Targeting and Immunity
32 8th Annual Meeting • June 1 - 5, 2005 • St. Louis SCIENTIFIC PROGRAM THURSDAY, JUNE 2, 2005 Workshop 224 Musculo-Skeletal: Myogenic Stem Cells and Regeneration Room: 230/231 Co-Chairs: Jeffrey Chamberlain, PhD Shin’ichi Takeda, MD, PhD Speakers: Shin’ichi Takeda, MD, PhD - Contribution of CD31-negative/CD45-negative Side Population Cells to Skeletal Muscle Regeneration Morayma Reyes, MD, PhD - Muscle Multipotent Adult Progenitor Cells (MAPC): Their Origin, Role and Clinical Potential in Muscle Disease Stephen D. Hauschka, PhD - Regulatory Cassette Design for Optimal Expression in Skeletal and Cardiac Muscle Following In Vivo and Ex Vivo Gene Delivery Thomas A. Rando, MD, PhD - Molecular Control of Muscle Stem Cell Activity Johnny Huard, PhD - Gene Therapy Based on Muscle-derived Stem Cells: Potential for Tissue Regeneration and Repair Emanuela Gussoni, PhD - Human Muscle Progenitor Cell Quiescence Maintained by Elevated BMP4 Expression Workshop 225 Neural Disorders: Gene Therapy and Behavior Room: Ferrara Theater Chair: Pedro Lowenstein, MD, PhD Speakers: Mary Bartlett Bunge, PhD - Using Gene Therapy to Improve Repair of the Injured Spinal Cord William J. Bowers, PhD - Functional Assessment of Gene-based A² Immunotherapy in a Mouse Model of Alzheimer’s Disease James B. Uney, PhD - Practical Approaches to Using Viral Vectors Provisional to Study the Molecular Basis of Behavioral Function Michael Kaplitt, MD, PhD - Gene Therapy to Alter Sexual Behavior Xandra Breakefield, PhD - HSV Amplicon Vector Delivery of Gonadotropin Releasing Hormone Gene (13 kb) to Hypothalamus Restores Estrous Activity in Hypogonadal Mice Workshop 226 Nonviral: New Approaches in Nonviral Gene Delivery Room: 260/264 Co-Chairs: Stephen Hart, PhD Leaf Huang, PhD Speakers: Esther H. Chang, PhD - Tumor Targeting Nanodelivery Systems: Expanding the Potential for Cancer Therapy and Diagnosis Mark E. Davis, PhD - A Systems Approach to the Design and Development of Non-Viral Delivery Systems Muna Naash, PhD - DNA Nanoparticles for Non-Viral Ocular Gene Transfer Lonnie D. Shea, PhD - Controlled Release Systems for Non-viral Vectors Alexander V. Kabanov, PhD - Transcriptional Activation of Gene Expression by Pluronic Ian MacLachlan, PhD - Clinical Pharmacology of Stable Plasmid Lipid Particles for Systemic Administration Workshop 227 Special: The Clinical Trial Data on adp53 Gene Therapy of Cancer Room: 240 Complex Co-Chairs: James S. Norris, PhD Helen E. Heslop, MD Speakers: Jack A. Roth, MD - Adp53 Clinical Trials Dmitry Gabrilovich, MD, PhD - Immunotherapy of Cancer with Dendritic Cell Based p53 Vaccine Yongsong Guan, MD - Transcatheter Hepatic Arterial Chemoembolization and Gendicine Combined in Treatment of Advanced Hepatocellular Carcinoma(HCC) Workshop 228 Special: Skin Gene Therapy Room: 261/262 Chair: Ulrich R. Hengge, MD Speaker: Ulrich R. Hengge, MD - Naked DNA: From Basics to Application Ernst Wagner, PhD - Bioresponsive Deshielding of Targeted DNA Polyplexes Lorne Taichman, MD, MSc, PhD - Long-term Systemic Delivery From Genetically Modified Human Skin MEET-THE-INVESTIGATOR LUNCH SESSIONS – 12:45 PM - 1:45 PM Meet-the-Investigator 230 Room: Washington Avenue A Chair: Jeffrey Chamberlain, PhD - Systemic Delivery of Genes to Muscle Using rAAV
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156 NOTES 8th Annual Meeting • Ju
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