FINAL PROGR AM - American Society of Gene & Cell Therapy
FINAL PROGR AM - American Society of Gene & Cell Therapy
FINAL PROGR AM - American Society of Gene & Cell Therapy
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112<br />
8th Annual Meeting • June 1 - 5, 2005 • St. Louis<br />
ABSTRACTS<br />
SUNDAY, JUNE 5<br />
Oral Abstract Session 511<br />
AAV Vectors: Disease Applications<br />
Room: 260/264<br />
1080 10:15 <strong>AM</strong><br />
rAAV Delivered Ribozyme Targeting Mouse Opsin to<br />
Rescue Vision in P23H Rats<br />
Marina S. Gorbatyuk, Adrian M. Timmers, Pang Jijing,<br />
William W. Hauswirth, Alfred S. Lewin<br />
1081 10:30 <strong>AM</strong><br />
Sustained Correction <strong>of</strong> Disease in Naïve and AAV2-<br />
Pretreated Hemophilia B Dogs Using Pseudotyped AAV<br />
Vectors<br />
Lili Wang, Roberto Calcedo, Timothy C. Nichols, Inder M.<br />
Verma, James M. Wilson<br />
1082 10:45 <strong>AM</strong><br />
Transduction Comparison <strong>of</strong> AAV Serotype Vectors in the<br />
Central Nervous System<br />
Sharon K. Reimsnider, Fredric Manfredsson, Nick Muzyczka,<br />
Ronald J. Mandel<br />
1083 11:00 <strong>AM</strong><br />
Systemic rAAV-CB-IL-10 Expression and Its Long Term<br />
Effects on CD4+CD25+ T <strong>Cell</strong> Populations<br />
Christian Muller, S<strong>of</strong>ia A. Braag, Ashley Martino, Mark A.<br />
Atkinson, Terence R. Flotte<br />
1084 11:15 <strong>AM</strong><br />
A Screen for Host <strong>Cell</strong>ular Proteins That Interact with<br />
Adeno-Associated Virus Capsid Proteins<br />
Bassel Akache, Daria Glazer, Julie Park, Mark A. Kay<br />
1085 11:30 <strong>AM</strong><br />
Directed Evolution <strong>of</strong> AAV2 Leads to Improved Viral<br />
Function<br />
James T. Koerber, Narendra Maheshri, Brian Kaspar, David V.<br />
Schaffer<br />
1086 11:45 <strong>AM</strong><br />
Patterns <strong>of</strong> <strong>Gene</strong> Expression from In Utero Delivery <strong>of</strong><br />
AAV Serotype 1<br />
Roberto Bilbao, Daniel P. Reay, Juan Li, Xiao Xiao, Paula R.<br />
Clemens<br />
1087 12:00 PM<br />
Adeno-Associated Virus-Mediated Transduction <strong>of</strong><br />
VEGF165 Markedly Improves Functional Recovery <strong>of</strong><br />
Infarcted Myocardium in Chronically Instrumented Dogs<br />
Matteo Ferrarini, Nikola Arsic, Serena Zacchigna, Fabio<br />
Recchia, Lorena Zentilin, Mauro Giacca, Thomas Hintze<br />
Oral Abstract Session 512<br />
Adenovirus Vectors: Adaptive Immunity and Vaccines<br />
Room: 120/124<br />
1088 10:15 <strong>AM</strong><br />
Antigen Epitopes Expressed in Different Adenovirus<br />
Capsid Proteins Induce Different Levels <strong>of</strong> Epitope-<br />
Specific Immunity<br />
Anja Krause, Stefan Worgall, Ju H. Joh, Neil R. Hackett, Peter<br />
W. Roelvink, Joseph T. Bruder, Thomas J. Wickham, Imre<br />
Kovesdi, Ronald G. Crystal<br />
1089 10:30 <strong>AM</strong><br />
Examine the Cross-Reactivity <strong>of</strong> Vector-Specific T <strong>Cell</strong>s<br />
between Human Adenoviral H5 and Simian Adenoviral<br />
C7 Vector in Mice<br />
Yan Zhi, Di Wu, Heather Jordan, Guangping Gao, James M.<br />
Wilson<br />
1090 10:45 <strong>AM</strong><br />
Adenovirus Fiber Incorporates an Immunodominant<br />
MHC Class I Restricted Epitope Peptide<br />
Jian Chen, Allan J. Zajac, Xin Xu, PingAr Yang, Qi Wu,<br />
Kohtaro Fujihashi, Hui-Chen Hsu, John D. Mountz<br />
1091 11:00 <strong>AM</strong><br />
Analysis <strong>of</strong> T-<strong>Cell</strong> Responses to Helper-Dependent<br />
Serotype 5-Based Capsid-Modified Adenovirus (HD.5/<br />
35) or First-<strong>Gene</strong>ration Serotype 11- Based (Ad11)<br />
Vectors<br />
Nelson C. Di Paolo, Daniel Stone, Andre Lieber<br />
1092 11:15 <strong>AM</strong><br />
Adenovirus-Based Vaccine Prevents Pneumonia in<br />
Ferrets Challenged with the SARS Coronavirus<br />
Gary P. Kobinger, Thomas Rowe, Guangping Gao, Joanita M.<br />
Figueredo, Julio Sanmiguel, Peter Bell, Robert J. Hogan, James<br />
M. Wilson<br />
1093 11:30 <strong>AM</strong><br />
An Adenovirus-Retrotransposon Hybrid Vector Achieves<br />
Stable Transformation <strong>of</strong> Quiescent and Primary Human<br />
Somatic <strong>Cell</strong>s<br />
Shuji Kubo, Harris S. Soifer, Marie del Carmen Seleme, John<br />
V. Moran, Haig H. Kazazian Jr., Noriyuki Kasahara<br />
1094 11:45 <strong>AM</strong><br />
A Novel Replication Competent, but Packaging Deficient<br />
Adenoviral(Ad) Vector [E1+, 100K-]hGAA for<br />
High Level hGAA Expression and Reduced Toxicity in<br />
<strong>Gene</strong> <strong>Therapy</strong> <strong>of</strong> Glycogen Storage Disease II (GSD-II)<br />
Fang Xu, Zachary Hartman, Delila Serra, Andrea Amalfitano<br />
1095 12:00 PM<br />
Silica Gel in Targeted and Controlled Viral <strong>Gene</strong> <strong>Therapy</strong><br />
Mika K. Koskinen, Mervi Toriseva, Mika J. Jokinen, Harry<br />
Jalonen, Jukka I. Salonen, Veli-Matti Kähäri
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