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Severe Sepsis Therapy: NumerousInvestigational ApproachesBacterial modulatorsAnti-endotoxinAnticytokinesIL-1ra, anti-TNF, sTNF-rAntiinflammatory agentsGlucocorticoids, leukocyte adhesion molecule inhibitorsHemostatic agentsRecombinant Human Activated Protein C, ATIII, TFPI, heparinOtheriNOS inhibition, antioxidants, thromboxane antagonists, bradykininreceptor antagonistsWheeler AP et al. N Engl J Med. 1999;340:207-14.38