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2001 SCCM/ESICM/ACCP/ATS/SISInternational Sepsis Definitions Conference• Cardiac index > 3.5• Arterial hypoxemia P/F < 300• Acute oliguria < 0.5ml/kg for > 2 hrs• Creatinine increase > 0.5 mg/dl• Coagulation abnormalitiesaPTT > 60 sec, INR > 1.5• Thrombocytopenia < 100,000 µl• Hyperbilirubinemia > 4 mg/dl• Hyperlactatemia > 24 mg/dl• Ileus (absent bowel sounds)• Decreased capillary refill or mottling• Altered mental status27