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2001 SCCM/ESICM/ACCP/ATS/SISInternational Sepsis Definitions Conference• Leukocytosis > 12,000 µl• Leukopenia < 4,000 µl• Normal WBC with > 10% immature• CRP > 2 SD above normal value• Procalcitonine > 2 SD above nl value• Arterial hypotension mean < 70 mmHg• Mixed venous oxygen sat < 70%26
2001 SCCM/ESICM/ACCP/ATS/SISInternational Sepsis Definitions Conference• Cardiac index > 3.5• Arterial hypoxemia P/F < 300• Acute oliguria < 0.5ml/kg for > 2 hrs• Creatinine increase > 0.5 mg/dl• Coagulation abnormalitiesaPTT > 60 sec, INR > 1.5• Thrombocytopenia < 100,000 µl• Hyperbilirubinemia > 4 mg/dl• Hyperlactatemia > 24 mg/dl• Ileus (absent bowel sounds)• Decreased capillary refill or mottling• Altered mental status27
Page 5 and 6: Neisseria Meningitidis5
Page 7 and 8: Epidemiologie7
Page 10: Severe Sepsis:A Growing Healthcare
Page 13 and 14: Microbiological eventInfectionSite
Page 15 and 16: BurnsSepsisPancreatitisInfectionSIR
Page 17 and 18: Identifying Acute Organ Dysfunction
Page 19 and 20: Een aantalproblemen …19
Page 21 and 22: Definitie woord “bal” =een bolv
Page 23 and 24: Host responseInfectionSIRS- fever o
Page 25: 2001 SCCM/ESICM/ACCP/ATS/SISInterna
Page 30: 1) Definitie van SIRS ….. en duso
Page 33 and 34: Sepsis classificationConsensus Meet
Page 35 and 36: Severe Sepsis:The Final Common Path
Page 37 and 38: BehandelingBehandeling van infectie
Page 39: Human Protein C300CHOCHO320EGFDomai

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