Treatment of invasive candidiasis in non-haematological patients

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Empirical treatment is most ofteninappropriate in septic ICU patientsinfected with…1.Staphylococcus aureus2.Pseudomonas aeruginosa3.Klebsiella species4.Candida albicans
Success at EIV treatment by pathogenDifference driven by C. albicans infections!% Success75.6%∆15.4%P=0.00960.2%81.1%∆18.8%P=0.01562.3%AnidulafunginFluconazole71.1%∆11.1%P=0.2660.0%All patientsn=60 n=38 n=32 n=27C. albicans(N=74)(N=61)Non-albicans(N=45)(N=45)* Patients with a single baseline pathogenReboli NEJM 2007
Page 5 and 6: EpidemiologyMainly data from the US
Page 7 and 8: Survival in candidemia, species rel
Page 9 and 10: Question1 : Which Candida species i
Page 11 and 12: Incidence and mortality of Candida
Page 13 and 14: HOW TO IDENTIFY PATIENTSAT RISK FOR
Page 15 and 16: Question 2: Which factor has the gr
Page 17 and 18: Identification of patients“Ostros
Page 19 and 20: Question3: What’s the problem wit
Page 21 and 22: Identification of patients“Ostros
Page 23 and 24: Are the risk predictive models gene
Page 25 and 26: Question 4: Empirical treatment is
Page 27 and 28: HOW TO PREVENT INVASIVECANDIDIASIS
Page 29 and 30: Empirical antifungal therapy in ICU
Page 31 and 32: TREATMENT OF INVASIVECANDIDIASIS
Page 33 and 34: Why do we choose whichantifungal dr
Page 35 and 36: Randomized Non-Inferior TrialsAmB v
Page 37 and 38: Caspofungin vs. Amphotericin B tria
Page 39 and 40: Micafungin vs. L-AmB in ICU Patient
Page 41 and 42: Anidulafungin vs. fluconazole study
Page 43 and 44: Success rates different echinocandi
Page 45 and 46: Question 5: Should the intravascula
Page 47 and 48: Antifungal agents and survivalCandi
Page 49 and 50: In conclusion• Invasive candidias
Page 51: Treatment of candidemia-Candida spe
Page 55 and 56: Question 6: Should the intravascula
Page 57 and 58: Candida Scorein practiceProspective

Treatment of invasive candidiasis in non-haematological patients

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